| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | WELLINGTON MANAGEMENT GROUP LLP | 25,485,831 | 1,846,959,000 | 14.17% | ||
| 2 | BAKER BROS. ADVISORS LP | 23,498,460 | 1,702,933,000 | 13.06% | ||
| 3 | PRICE T ROWE ASSOCIATES INC /MD/ | 16,135,252 | 1,169,322,000 | 8.97% | ||
| 4 | VANGUARD GROUP INC | 11,632,384 | 842,999,000 | 6.47% | ||
| 5 | Capital World Investors | 10,552,491 | 764,739,000 | 5.87% | ||
| 6 | Capital International Investors | 5,418,497 | 392,678,000 | 3.01% | ||
| 7 | FMR LLC | 4,871,325 | 353,025,000 | 2.71% | ||
| 8 | BlackRock Fund Advisors | 4,020,248 | 291,347,000 | 2.24% | ||
| 9 | BlackRock Institutional Trust Company, N.A. | 3,935,719 | 285,222,000 | 2.19% | ||
| 10 | BB BIOTECH AG | 3,840,406 | 278,314,000 | 2.14% | ||
| 11 | SANDS CAPITAL MANAGEMENT, LLC | 3,819,401 | 276,792,000 | 2.12% | ||
| 12 | STATE STREET CORP | 3,398,252 | 246,259,000 | 1.89% | ||
| 13 | BROWN CAPITAL MANAGEMENT LLC | 2,917,673 | 211,444,000 | 1.62% | ||
| 14 | ORBIMED ADVISORS LLC | 2,755,078 | 199,661,000 | 1.53% | ||
| 15 | FRANKLIN RESOURCES INC | 2,306,929 | 167,185,000 | 1.28% | ||
| 16 | Invesco Ltd. | 2,262,724 | 163,979,000 | 1.26% | ||
| 17 | CAPITAL GUARDIAN TRUST CO | 2,095,255 | 151,843,000 | 1.16% | ||
| 18 | JPMORGAN CHASE & CO | 1,889,957 | 136,965,000 | 1.05% | ||
| 19 | AMERIPRISE FINANCIAL INC | 1,638,728 | 118,754,000 | 0.91% | ||
| 20 | JANUS HENDERSON INVESTORS US LLC | 1,620,281 | 117,424,000 | 0.90% | ||
| 21 | NORGES BANK | 1,465,856 | 106,230,000 | 0.81% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,326,579 | 96,138,000 | 0.74% | ||
| 23 | SECTORAL ASSET MANAGEMENT INC | 1,153,540 | 83,597,000 | 0.64% | ||
| 24 | DEUTSCHE BANK AG\ | 1,111,727 | 80,562,000 | 0.62% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 1,068,236 | 77,372,000 | 0.59% | ||
| 26 | GOLDMAN SACHS GROUP INC | 1,035,290 | 75,028,000 | 0.58% | ||
| 27 | BlackRock Group LTD | 1,010,530 | 73,232,000 | 0.56% | ||
| 28 | WELLS FARGO & COMPANY/MN | 994,095 | 72,041,000 | 0.55% | ||
| 29 | AMERICAN CENTURY COMPANIES INC | 976,754 | 70,785,000 | 0.54% | ||
| 30 | Tekla Capital Management LLC | 956,461 | 69,315,000 | 0.53% | ||
| 31 | JENNISON ASSOCIATES LLC | 938,793 | 68,034,000 | 0.52% | ||
| 32 | CANADA PENSION PLAN INVESTMENT BOARD | 907,321 | 65,754,000 | 0.50% | ||
| 33 | TWO SIGMA ADVISERS, LP | 904,363 | 65,539,000 | 0.50% | ||
| 34 | GILDER GAGNON HOWE & CO LLC | 871,984 | 63,193,000 | 0.48% | ||
| 35 | NEW YORK STATE COMMON RETIREMENT FUND | 842,726 | 61,072,000 | 0.47% | ||
| 36 | NORTHERN TRUST CORP | 826,579 | 59,902,000 | 0.46% | ||
| 37 | FEDERATED HERMES, INC. | 717,307 | 51,983,000 | 0.40% | ||
| 38 | Bank of New York Mellon Corp | 706,328 | 51,187,000 | 0.39% | ||
| 39 | ROYAL BANK OF CANADA | 621,527 | 45,042,000 | 0.35% | ||
| 40 | FIRST TRUST ADVISORS LP | 606,962 | 43,987,000 | 0.34% | ||
| 41 | Artal Group S.A. | 600,000 | 43,482,000 | 0.33% | ||
| 42 | Legal & General Group Plc | 598,671 | 43,385,000 | 0.33% | ||
| 43 | BANK OF AMERICA CORP /DE/ | 597,879 | 43,328,000 | 0.33% | ||
| 44 | TWO SIGMA INVESTMENTS, LP | 579,073 | 41,965,000 | 0.32% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 562,253 | 40,746,000 | 0.31% | ||
| 46 | CREDIT SUISSE AG/ | 526,280 | 38,141,000 | 0.29% | ||
| 47 | CAPITAL INTERNATIONAL LTD /CA/ | 519,900 | 37,677,000 | 0.29% | ||
| 48 | Sumitomo Mitsui Trust Group, Inc. | 499,905 | 36,228,000 | 0.28% | ||
| 49 | FRED ALGER MANAGEMENT, LLC | 497,956 | 36,087,000 | 0.28% | ||
| 50 | MILLENNIUM MANAGEMENT LLC | 492,265 | 35,674,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
