| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | BAKER BROS. ADVISORS LP | 19,474,969 | 2,148,673,000 | 11.13% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 19,202,896 | 2,118,656,000 | 10.97% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 13,203,286 | 1,456,719,000 | 7.55% | ||
| 4 | Capital World Investors | 12,505,383 | 1,379,719,000 | 7.15% | ||
| 5 | VANGUARD GROUP INC | 11,079,069 | 1,222,354,000 | 6.33% | ||
| 6 | Capital International Investors | 5,387,278 | 594,378,000 | 3.08% | ||
| 7 | FMR LLC | 5,055,934 | 557,821,000 | 2.89% | ||
| 8 | JENNISON ASSOCIATES LLC | 4,568,898 | 504,087,000 | 2.61% | ||
| 9 | BlackRock Fund Advisors | 4,084,524 | 450,646,000 | 2.33% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 3,843,503 | 424,054,000 | 2.20% | ||
| 11 | BB BIOTECH AG | 3,750,406 | 413,782,000 | 2.14% | ||
| 12 | JPMORGAN CHASE & CO | 3,219,391 | 355,196,000 | 1.84% | ||
| 13 | STATE STREET CORP | 2,866,376 | 316,235,000 | 1.64% | ||
| 14 | ORBIMED ADVISORS LLC | 2,740,978 | 302,412,000 | 1.57% | ||
| 15 | FRANKLIN RESOURCES INC | 2,701,875 | 298,103,000 | 1.54% | ||
| 16 | Artisan Partners Limited Partnership | 2,285,723 | 252,184,000 | 1.31% | ||
| 17 | CAPITAL GUARDIAN TRUST CO | 2,281,409 | 251,708,000 | 1.30% | ||
| 18 | Invesco Ltd. | 1,957,539 | 215,975,000 | 1.12% | ||
| 19 | FIRST TRUST ADVISORS LP | 1,812,796 | 200,006,000 | 1.04% | ||
| 20 | BROWN CAPITAL MANAGEMENT LLC | 1,658,050 | 182,933,000 | 0.95% | ||
| 21 | AMERIPRISE FINANCIAL INC | 1,567,326 | 172,913,000 | 0.90% | ||
| 22 | WELLS FARGO & COMPANY/MN | 1,556,327 | 171,710,000 | 0.89% | ||
| 23 | NORGES BANK | 1,492,550 | 164,673,000 | 0.85% | ||
| 24 | FRED ALGER MANAGEMENT, LLC | 1,288,580 | 142,169,000 | 0.74% | ||
| 25 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 1,206,606 | 133,124,000 | 0.69% | ||
| 26 | CANADA PENSION PLAN INVESTMENT BOARD | 1,206,486 | 133,112,000 | 0.69% | ||
| 27 | GILDER GAGNON HOWE & CO LLC | 1,033,764 | 114,055,000 | 0.59% | ||
| 28 | JANUS HENDERSON INVESTORS US LLC | 1,033,460 | 114,021,000 | 0.59% | ||
| 29 | AMERICAN CENTURY COMPANIES INC | 1,020,243 | 112,563,000 | 0.58% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 966,018 | 106,513,000 | 0.55% | ||
| 31 | BlackRock Group LTD | 926,686 | 102,241,000 | 0.53% | ||
| 32 | DEUTSCHE BANK AG\ | 926,320 | 102,195,000 | 0.53% | ||
| 33 | NORTHERN TRUST CORP | 913,142 | 100,748,000 | 0.52% | ||
| 34 | TWO SIGMA ADVISERS, LP | 897,307 | 99,606,000 | 0.52% | ||
| 35 | SECTORAL ASSET MANAGEMENT INC | 887,051 | 97,868,000 | 0.51% | ||
| 36 | Tekla Capital Management LLC | 880,461 | 97,141,000 | 0.50% | ||
| 37 | 1832 Asset Management L.P. | 864,800 | 93,773,000 | 0.49% | ||
| 38 | TWO SIGMA INVESTMENTS, LP | 801,285 | 88,406,000 | 0.46% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 797,081 | 87,942,000 | 0.46% | ||
| 40 | NEW YORK STATE COMMON RETIREMENT FUND | 755,652 | 83,371,000 | 0.43% | ||
| 41 | WADDELL & REED FINANCIAL INC | 733,000 | 80,872,000 | 0.42% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 732,583 | 80,826,000 | 0.42% | ||
| 43 | OppenheimerFunds, Inc. | 710,862 | 78,429,000 | 0.41% | ||
| 44 | Bank of New York Mellon Corp | 688,112 | 75,920,000 | 0.39% | ||
| 45 | GOLDMAN SACHS GROUP INC | 667,267 | 73,619,000 | 0.38% | ||
| 46 | FRONTIER CAPITAL MANAGEMENT CO LLC | 664,034 | 73,263,000 | 0.38% | ||
| 47 | FEDERATED HERMES, INC. | 662,600 | 73,105,000 | 0.38% | ||
| 48 | GOLDMAN SACHS GROUP INC | 631,000 | 69,618,000 | 0.36% | Call | |
| 49 | Redmile Group, LLC | 613,598 | 67,698,000 | 0.35% | ||
| 50 | Legal & General Group Plc | 575,940 | 63,543,000 | 0.33% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
