| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | PRICE T ROWE ASSOCIATES INC /MD/ | 10,294,551 | 176,654,000 | 17.82% | ||
| 2 | FMR LLC | 9,303,816 | 159,653,000 | 16.10% | ||
| 3 | Palo Alto Investors LP | 5,621,816 | 96,470,000 | 9.73% | ||
| 4 | BlackRock Finance, Inc. | 4,699,197 | 80,637,000 | 8.13% | ||
| 5 | ORBIMED ADVISORS LLC | 4,393,509 | 75,393,000 | 7.60% | ||
| 6 | VANGUARD GROUP INC | 3,827,881 | 65,687,000 | 6.63% | ||
| 7 | STATE STREET CORP | 1,728,017 | 29,651,000 | 2.99% | ||
| 8 | JANUS HENDERSON GROUP PLC | 1,648,703 | 28,292,000 | 2.85% | ||
| 9 | EMERALD ADVISERS, LLC | 1,285,365 | 22,057,000 | 2.22% | ||
| 10 | JENNISON ASSOCIATES LLC | 1,167,265 | 20,030,000 | 2.02% | ||
| 11 | EMERALD MUTUAL FUND ADVISERS TRUST | 1,036,283 | 17,783,000 | 1.79% | ||
| 12 | JPMORGAN CHASE & CO | 998,178 | 17,129,000 | 1.73% | ||
| 13 | NORTHERN TRUST CORP | 825,617 | 14,167,000 | 1.43% | ||
| 14 | CITADEL ADVISORS LLC | 652,733 | 11,201,000 | 1.13% | ||
| 15 | NORGES BANK | 616,674 | 10,582,000 | 1.07% | ||
| 16 | GREAT POINT PARTNERS LLC | 538,473 | 9,240,000 | 0.93% | ||
| 17 | GEODE CAPITAL MANAGEMENT, LLC | 531,151 | 9,114,000 | 0.92% | ||
| 18 | Ghost Tree Capital, LLC | 475,000 | 8,151,000 | 0.82% | ||
| 19 | Rock Springs Capital Management LP | 468,000 | 8,031,000 | 0.81% | ||
| 20 | MORGAN STANLEY | 409,741 | 7,032,000 | 0.71% | ||
| 21 | BAKER BROS. ADVISORS LP | 400,000 | 6,864,000 | 0.69% | ||
| 22 | AXA S.A. | 374,773 | 6,431,000 | 0.65% | ||
| 23 | Bank of New York Mellon Corp | 330,873 | 5,677,000 | 0.57% | ||
| 24 | DLD ASSET MANAGEMENT, LP | 295,000 | 5,062,000 | 0.51% | Put | |
| 25 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 281,650 | 4,834,000 | 0.49% | ||
| 26 | JENNISON ASSOCIATES LLC | 270,000 | 4,633,000 | 0.47% | Put | |
| 27 | Sio Capital Management, LLC | 266,600 | 4,575,000 | 0.46% | Put | |
| 28 | DEUTSCHE BANK AG\ | 236,669 | 4,060,000 | 0.41% | ||
| 29 | TD ASSET MANAGEMENT INC | 224,750 | 3,857,000 | 0.39% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 213,525 | 3,664,000 | 0.37% | ||
| 31 | PRINCIPAL FINANCIAL GROUP INC | 202,443 | 3,474,000 | 0.35% | ||
| 32 | TEACHERS ADVISORS, LLC | 193,807 | 3,326,000 | 0.34% | ||
| 33 | GOLDMAN SACHS GROUP INC | 171,840 | 2,949,000 | 0.30% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 167,700 | 2,878,000 | 0.29% | Call | |
| 35 | NEXTHERA CAPITAL LP | 160,000 | 2,746,000 | 0.28% | ||
| 36 | D. E. Shaw & Co., Inc. | 151,230 | 2,595,000 | 0.26% | ||
| 37 | SECTORAL ASSET MANAGEMENT INC | 145,799 | 2,502,000 | 0.25% | ||
| 38 | J. Goldman & Co LP | 145,088 | 2,490,000 | 0.25% | ||
| 39 | C WorldWide Group Holding A/S | 141,471 | 2,428,000 | 0.24% | ||
| 40 | CHARTWELL INVESTMENT PARTNERS, LLC | 141,018 | 2,420,000 | 0.24% | ||
| 41 | UNIVERSITY OF NOTRE DAME DU LAC | 140,761 | 2,415,000 | 0.24% | ||
| 42 | PICTET ASSET MANAGEMENT LTD | 131,143 | 2,022,000 | 0.20% | ||
| 43 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 109,920 | 1,886,000 | 0.19% | ||
| 44 | Hudson Bay Capital Management LP | 100,000 | 1,716,000 | 0.17% | ||
| 45 | Swiss National Bank | 96,800 | 1,661,000 | 0.17% | ||
| 46 | DLD ASSET MANAGEMENT, LP | 96,730 | 1,660,000 | 0.17% | ||
| 47 | ALLIANCEBERNSTEIN L.P. | 90,700 | 1,556,000 | 0.16% | ||
| 48 | CREDIT SUISSE AG/ | 86,672 | 1,488,000 | 0.15% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 82,600 | 1,417,000 | 0.14% | ||
| 50 | NEW YORK STATE COMMON RETIREMENT FUND | 81,044 | 1,391,000 | 0.14% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
