| 1 |
FMR LLC |
5,359,831 |
35,964,000 |
26.69% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
3,278,123 |
21,996,000 |
16.32% |
|
|
| 3 |
Palo Alto Investors LP |
3,139,433 |
21,066,000 |
15.63% |
|
|
| 4 |
WELLINGTON MANAGEMENT GROUP LLP |
1,490,644 |
10,003,000 |
7.42% |
|
|
| 5 |
BlackRock Fund Advisors |
1,069,779 |
7,178,000 |
5.33% |
|
|
| 6 |
VANGUARD GROUP INC |
816,444 |
5,478,000 |
4.07% |
|
|
| 7 |
MILLENNIUM MANAGEMENT LLC |
714,104 |
4,792,000 |
3.56% |
|
|
| 8 |
BlackRock Institutional Trust Company, N.A. |
530,816 |
3,562,000 |
2.64% |
|
|
| 9 |
Tekla Capital Management LLC |
500,324 |
3,357,000 |
2.49% |
|
|
| 10 |
STATE STREET CORP |
371,372 |
2,491,000 |
1.85% |
|
|
| 11 |
JPMORGAN CHASE & CO |
361,979 |
2,428,000 |
1.80% |
|
|
| 12 |
NORTHERN TRUST CORP |
257,473 |
1,727,000 |
1.28% |
|
|
| 13 |
New Leaf Venture Partners, L.L.C. |
222,947 |
1,496,000 |
1.11% |
|
|
| 14 |
BAKER BROS. ADVISORS LP |
216,990 |
1,456,000 |
1.08% |
|
|
| 15 |
Candriam S.C.A. |
160,000 |
1,074,000 |
0.80% |
|
|
| 16 |
GEODE CAPITAL MANAGEMENT, LLC |
143,471 |
962,000 |
0.71% |
|
|
| 17 |
Bank of New York Mellon Corp |
101,558 |
682,000 |
0.51% |
|
|
| 18 |
BlackRock Investment Management, LLC |
93,568 |
628,000 |
0.47% |
|
|
| 19 |
MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC |
87,466 |
587,000 |
0.44% |
|
|
| 20 |
DEUTSCHE BANK AG\ |
84,598 |
567,000 |
0.42% |
|
|
| 21 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
76,318 |
512,000 |
0.38% |
|
|
| 22 |
RHUMBLINE ADVISERS |
64,460 |
433,000 |
0.32% |
|
|
| 23 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
60,498 |
406,000 |
0.30% |
|
|
| 24 |
BANK OF AMERICA CORP /DE/ |
57,304 |
385,000 |
0.29% |
|
|
| 25 |
TFS CAPITAL LLC |
49,883 |
335,000 |
0.25% |
|
|
| 26 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
49,544 |
332,000 |
0.25% |
|
|
| 27 |
TCW GROUP INC |
41,652 |
279,000 |
0.21% |
|
|
| 28 |
GOLDMAN SACHS GROUP INC |
41,264 |
277,000 |
0.21% |
|
|
| 29 |
NEW YORK STATE COMMON RETIREMENT FUND |
36,966 |
248,000 |
0.18% |
|
|
| 30 |
Swiss National Bank |
36,850 |
247,000 |
0.18% |
|
|
| 31 |
JACOBS LEVY EQUITY MANAGEMENT, INC |
36,300 |
244,000 |
0.18% |
|
|
| 32 |
TEACHERS ADVISORS, LLC |
36,017 |
242,000 |
0.18% |
|
|
| 33 |
ALLIANCEBERNSTEIN L.P. |
34,930 |
234,000 |
0.17% |
|
|
| 34 |
STONERIDGE INVESTMENT PARTNERS LLC |
32,465 |
218,000 |
0.16% |
|
|
| 35 |
VIRTUS ETF ADVISERS LLC |
30,617 |
205,000 |
0.15% |
|
|
| 36 |
HIGHBRIDGE CAPITAL MANAGEMENT LLC |
29,907 |
200,000 |
0.15% |
|
|
| 37 |
ProShare Advisors LLC |
29,655 |
199,000 |
0.15% |
|
|
| 38 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
24,900 |
167,000 |
0.12% |
Call |
|
| 39 |
Nationwide Fund Advisors |
21,258 |
143,000 |
0.11% |
|
|
| 40 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
20,200 |
136,000 |
0.10% |
|
|
| 41 |
METROPOLITAN LIFE INSURANCE CO/NY |
20,210 |
136,000 |
0.10% |
|
|
| 42 |
CREDIT SUISSE AG/ |
19,963 |
134,000 |
0.10% |
|
|
| 43 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
17,059 |
115,000 |
0.09% |
|
|
| 44 |
ELLINGTON MANAGEMENT GROUP LLC |
16,200 |
109,000 |
0.08% |
|
|
| 45 |
PRICE T ROWE ASSOCIATES INC /MD/ |
13,874 |
93,000 |
0.07% |
|
|
| 46 |
AMERICAN INTERNATIONAL GROUP, INC. |
13,602 |
91,269 |
0.07% |
|
|
| 47 |
WELLS FARGO & COMPANY/MN |
13,695 |
91,000 |
0.07% |
|
|
| 48 |
STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM |
12,506 |
84,000 |
0.06% |
|
|
| 49 |
Paloma Partners Management Co |
11,720 |
79,000 |
0.06% |
|
|
| 50 |
Capital Impact Advisors, LLC |
11,662 |
78,000 |
0.06% |
|
|
