| 1 |
Novo Holdings A/S |
3,201,183 |
64,248,000 |
37.80% |
|
|
| 2 |
FRANKLIN RESOURCES INC |
820,500 |
16,467,000 |
9.69% |
|
|
| 3 |
FMR LLC |
767,604 |
15,406,000 |
9.06% |
|
|
| 4 |
PFM Health Sciences, LP |
738,027 |
14,812,000 |
8.71% |
|
|
| 5 |
BLACKROCK ADVISORS LLC |
449,001 |
9,011,000 |
5.30% |
|
|
| 6 |
PointState Capital LP |
275,000 |
5,519,000 |
3.25% |
|
|
| 7 |
BlackRock Fund Advisors |
196,908 |
3,952,000 |
2.33% |
|
|
| 8 |
BlackRock Group LTD |
169,831 |
3,408,000 |
2.01% |
|
|
| 9 |
WELLINGTON MANAGEMENT GROUP LLP |
154,919 |
3,109,000 |
1.83% |
|
|
| 10 |
BlackRock Institutional Trust Company, N.A. |
154,449 |
3,100,000 |
1.82% |
|
|
| 11 |
BAKER BROS. ADVISORS LP |
153,350 |
3,078,000 |
1.81% |
|
|
| 12 |
Cormorant Asset Management, LP |
150,000 |
3,011,000 |
1.77% |
|
|
| 13 |
JENNISON ASSOCIATES LLC |
125,000 |
2,509,000 |
1.48% |
|
|
| 14 |
CADIAN CAPITAL MANAGEMENT, LP |
100,000 |
2,007,000 |
1.18% |
|
|
| 15 |
FARALLON CAPITAL MANAGEMENT LLC |
100,000 |
2,007,000 |
1.18% |
|
|
| 16 |
DRIEHAUS CAPITAL MANAGEMENT LLC |
97,809 |
1,963,000 |
1.15% |
|
|
| 17 |
VANGUARD GROUP INC |
82,139 |
1,649,000 |
0.97% |
|
|
| 18 |
MORGAN STANLEY |
79,319 |
1,592,000 |
0.94% |
|
|
| 19 |
BlackRock Finance, Inc. |
68,900 |
1,383,000 |
0.81% |
|
|
| 20 |
STATE STREET CORP |
67,111 |
1,345,000 |
0.79% |
|
|
| 21 |
Nicholas Investment Partners, LP |
50,456 |
1,013,000 |
0.60% |
|
|
| 22 |
SECTORAL ASSET MANAGEMENT INC |
40,525 |
813,000 |
0.48% |
|
|
| 23 |
BlackRock Investment Management, LLC |
39,585 |
794,000 |
0.47% |
|
|
| 24 |
Alyeska Investment Group, L.P. |
38,744 |
778,000 |
0.46% |
|
|
| 25 |
GEODE CAPITAL MANAGEMENT, LLC |
38,748 |
777,000 |
0.46% |
|
|
| 26 |
Bank of New York Mellon Corp |
38,484 |
773,000 |
0.45% |
|
|
| 27 |
WELLS FARGO & COMPANY/MN |
38,323 |
769,000 |
0.45% |
|
|
| 28 |
Spark Investment Management LLC |
32,100 |
642,000 |
0.38% |
|
|
| 29 |
NORTHERN TRUST CORP |
31,320 |
628,000 |
0.37% |
|
|
| 30 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
30,804 |
618,000 |
0.36% |
|
|
| 31 |
Partner Investment Management, L.P. |
27,893 |
560,000 |
0.33% |
|
|
| 32 |
ROYAL BANK OF CANADA |
18,528 |
372,000 |
0.22% |
|
|
| 33 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
14,600 |
293,000 |
0.17% |
|
|
| 34 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
11,700 |
235,000 |
0.14% |
|
|
| 35 |
TEACHERS ADVISORS, LLC |
11,418 |
229,000 |
0.13% |
|
|
| 36 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
11,251 |
226,000 |
0.13% |
|
|
| 37 |
DEUTSCHE BANK AG\ |
8,080 |
161,000 |
0.09% |
|
|
| 38 |
LADENBURG THALMANN FINANCIAL SERVICES INC. |
6,600 |
132,000 |
0.08% |
|
|
| 39 |
ALLIANCEBERNSTEIN L.P. |
6,300 |
126,000 |
0.07% |
|
|
| 40 |
Tower Research Capital LLC (TRC) |
6,058 |
122,000 |
0.07% |
|
|
| 41 |
Nationwide Fund Advisors |
6,079 |
122,000 |
0.07% |
|
|
| 42 |
AMERICAN INTERNATIONAL GROUP, INC. |
5,233 |
105,026 |
0.06% |
|
|
| 43 |
BlackRock Japan Co. Ltd |
3,444 |
69,000 |
0.04% |
|
|
| 44 |
VIRTUS CAPITAL ADVISERS, LLC |
682 |
14,000 |
0.01% |
|
|
| 45 |
MANAGED ACCOUNT ADVISORS LLC |
453 |
9,000 |
0.01% |
|
|
| 46 |
BARCLAYS PLC |
176 |
4,000 |
0.00% |
|
|
| 47 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
159 |
3,000 |
0.00% |
|
|
| 48 |
CITIGROUP INC |
68 |
1,000 |
0.00% |
|
|
