| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,510,264 | 156,214,000 | 13.99% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,937,041 | 102,704,000 | 9.20% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 3,613,997 | 75,170,000 | 6.73% | ||
| 4 | VANGUARD GROUP INC | 3,244,517 | 67,486,000 | 6.05% | ||
| 5 | PFM Health Sciences, LP | 2,913,951 | 60,610,000 | 5.43% | ||
| 6 | BlackRock Fund Advisors | 2,133,222 | 44,371,000 | 3.97% | ||
| 7 | STATE STREET CORP | 1,758,687 | 36,579,000 | 3.28% | ||
| 8 | BB BIOTECH AG | 1,685,150 | 35,051,000 | 3.14% | ||
| 9 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,628,328 | 33,869,000 | 3.03% | ||
| 10 | Cormorant Asset Management, LP | 1,581,604 | 32,897,000 | 2.95% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 1,549,442 | 32,228,000 | 2.89% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 1,248,310 | 25,965,000 | 2.33% | ||
| 13 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 25,761,000 | 2.31% | ||
| 14 | EAGLE ASSET MANAGEMENT INC | 1,119,539 | 23,286,000 | 2.09% | ||
| 15 | Foresite Capital Management II, LLC | 995,396 | 20,704,000 | 1.85% | ||
| 16 | Redmile Group, LLC | 920,550 | 19,147,000 | 1.72% | ||
| 17 | AMUNDI ASSET MANAGEMENT US, INC. | 804,885 | 16,742,000 | 1.50% | ||
| 18 | SECTORAL ASSET MANAGEMENT INC | 669,351 | 13,923,000 | 1.25% | ||
| 19 | GOLDMAN SACHS GROUP INC | 628,180 | 13,066,000 | 1.17% | ||
| 20 | EMERALD ADVISERS, LLC | 613,232 | 12,755,000 | 1.14% | ||
| 21 | NORTHERN TRUST CORP | 552,488 | 11,492,000 | 1.03% | ||
| 22 | BROWN ADVISORY INC | 497,953 | 10,358,000 | 0.93% | ||
| 23 | CLOUGH CAPITAL PARTNERS L P | 468,435 | 9,743,000 | 0.87% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 435,629 | 9,061,000 | 0.81% | ||
| 25 | EMERALD MUTUAL FUND ADVISERS TRUST | 417,963 | 8,694,000 | 0.78% | ||
| 26 | WESTFIELD CAPITAL MANAGEMENT CO LP | 398,315 | 8,285,000 | 0.74% | ||
| 27 | PERCEPTIVE ADVISORS LLC | 384,169 | 7,991,000 | 0.72% | ||
| 28 | Invesco Ltd. | 384,095 | 7,989,000 | 0.72% | ||
| 29 | WELLS FARGO & COMPANY/MN | 372,619 | 7,750,000 | 0.69% | ||
| 30 | PICTET ASSET MANAGEMENT LTD | 360,457 | 7,498,000 | 0.67% | ||
| 31 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 352,409 | 7,330,000 | 0.66% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 330,879 | 6,882,000 | 0.62% | ||
| 33 | MORGAN STANLEY | 320,295 | 6,661,000 | 0.60% | ||
| 34 | AXA S.A. | 266,758 | 5,549,000 | 0.50% | ||
| 35 | NORGES BANK | 262,153 | 5,453,000 | 0.49% | ||
| 36 | BLACKROCK ADVISORS LLC | 261,025 | 5,429,000 | 0.49% | ||
| 37 | FRANKLIN RESOURCES INC | 244,600 | 5,088,000 | 0.46% | ||
| 38 | New Leaf Venture Partners, L.L.C. | 228,428 | 4,751,000 | 0.43% | ||
| 39 | DAFNA Capital Management LLC | 221,013 | 4,597,000 | 0.41% | ||
| 40 | BAKER BROS. ADVISORS LP | 217,328 | 4,520,000 | 0.40% | ||
| 41 | EVENTIDE ASSET MANAGEMENT, LLC | 215,000 | 4,472,000 | 0.40% | ||
| 42 | ROYAL BANK OF CANADA | 206,897 | 4,304,000 | 0.39% | ||
| 43 | AMERIPRISE FINANCIAL INC | 203,674 | 4,237,000 | 0.38% | ||
| 44 | CREDIT SUISSE AG/ | 203,547 | 4,234,000 | 0.38% | ||
| 45 | Bank of New York Mellon Corp | 201,183 | 4,185,000 | 0.37% | ||
| 46 | BlackRock Investment Management, LLC | 182,686 | 3,800,000 | 0.34% | ||
| 47 | Rock Springs Capital Management LP | 182,000 | 3,786,000 | 0.34% | ||
| 48 | SAMLYN CAPITAL, LLC | 180,000 | 3,744,000 | 0.34% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 171,150 | 3,560,000 | 0.32% | ||
| 50 | Fiera Capital Corp | 168,627 | 3,507,000 | 0.31% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
