| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,563,585 | 160,742,000 | 14.48% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 5,238,150 | 128,297,000 | 11.55% | ||
| 3 | PFM Health Sciences, LP | 3,542,647 | 86,759,000 | 7.81% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,156,865 | 77,310,000 | 6.96% | ||
| 5 | VANGUARD GROUP INC | 2,199,184 | 53,857,000 | 4.85% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 1,592,907 | 39,010,000 | 3.51% | ||
| 7 | BB BIOTECH AG | 1,510,150 | 36,984,000 | 3.33% | ||
| 8 | Cormorant Asset Management, LP | 1,497,475 | 36,673,000 | 3.30% | ||
| 9 | SECTORAL ASSET MANAGEMENT INC | 1,291,153 | 31,620,000 | 2.85% | ||
| 10 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,278,570 | 31,312,000 | 2.82% | ||
| 11 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 30,332,000 | 2.73% | ||
| 12 | STATE STREET CORP | 1,195,800 | 29,282,000 | 2.64% | ||
| 13 | Point72 Asset Management, L.P. | 1,153,800 | 28,257,000 | 2.54% | ||
| 14 | EAGLE ASSET MANAGEMENT INC | 1,143,093 | 27,994,000 | 2.52% | ||
| 15 | BlackRock Fund Advisors | 1,136,823 | 27,841,000 | 2.51% | ||
| 16 | EverPoint Asset Management, LLC | 775,000 | 18,980,000 | 1.71% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 601,590 | 14,733,000 | 1.33% | ||
| 18 | Foresite Capital Management II, LLC | 530,416 | 12,990,000 | 1.17% | ||
| 19 | SENZAR ASSET MANAGEMENT, LLC | 513,570 | 12,577,329 | 1.13% | ||
| 20 | Invesco Ltd. | 494,588 | 12,113,000 | 1.09% | ||
| 21 | AMUNDI ASSET MANAGEMENT US, INC. | 422,718 | 10,352,000 | 0.93% | ||
| 22 | Asset Management One Co., Ltd. | 405,539 | 9,473,000 | 0.85% | ||
| 23 | BROWN ADVISORY INC | 380,674 | 9,322,000 | 0.84% | ||
| 24 | GOLDMAN SACHS GROUP INC | 367,804 | 9,008,000 | 0.81% | ||
| 25 | CITADEL ADVISORS LLC | 358,376 | 8,777,000 | 0.79% | ||
| 26 | JPMORGAN CHASE & CO | 349,482 | 8,559,000 | 0.77% | ||
| 27 | DEUTSCHE BANK AG\ | 309,165 | 7,569,000 | 0.68% | ||
| 28 | NORGES BANK | 308,308 | 7,550,000 | 0.68% | ||
| 29 | WELLS FARGO & COMPANY/MN | 276,059 | 6,760,000 | 0.61% | ||
| 30 | NORTHERN TRUST CORP | 267,827 | 6,560,000 | 0.59% | ||
| 31 | AXA S.A. | 253,179 | 6,200,000 | 0.56% | ||
| 32 | BLACKROCK ADVISORS LLC | 247,875 | 6,070,000 | 0.55% | ||
| 33 | New Leaf Venture Partners, L.L.C. | 247,806 | 6,069,000 | 0.55% | ||
| 34 | AMERIPRISE FINANCIAL INC | 215,531 | 5,280,000 | 0.48% | ||
| 35 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 191,482 | 4,689,000 | 0.42% | ||
| 36 | CREDIT SUISSE AG/ | 186,633 | 4,571,000 | 0.41% | ||
| 37 | BARCLAYS PLC | 190,000 | 4,560,000 | 0.41% | Put | |
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 179,237 | 4,389,000 | 0.40% | ||
| 39 | MARSHALL WACE, LLP | 175,020 | 4,286,000 | 0.39% | ||
| 40 | GOLDMAN SACHS GROUP INC | 150,000 | 3,674,000 | 0.33% | Put | |
| 41 | DAFNA Capital Management LLC | 140,313 | 3,436,000 | 0.31% | ||
| 42 | HIGHLAND CAPITAL MANAGEMENT LP | 125,000 | 3,061,000 | 0.28% | ||
| 43 | Apex Capital Management | 123,227 | 3,018,000 | 0.27% | ||
| 44 | BANK OF AMERICA CORP /DE/ | 119,229 | 2,920,000 | 0.26% | ||
| 45 | GUGGENHEIM CAPITAL LLC | 109,971 | 2,693,000 | 0.24% | ||
| 46 | Bank of New York Mellon Corp | 106,440 | 2,607,000 | 0.23% | ||
| 47 | PRUDENTIAL FINANCIAL INC | 104,100 | 2,549,000 | 0.23% | ||
| 48 | GRATICULE ASIA MACRO ADVISORS LLC | 100,000 | 2,449,000 | 0.22% | Call | |
| 49 | Rock Springs Capital Management LP | 97,500 | 2,388,000 | 0.22% | ||
| 50 | BlackRock Investment Management, LLC | 93,080 | 2,280,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
