| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,201,183 | 40,591,000 | 31.21% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,262,087 | 16,003,000 | 12.31% | ||
| 3 | PFM Health Sciences, LP | 1,034,030 | 13,112,000 | 10.08% | ||
| 4 | FMR LLC | 767,604 | 9,733,000 | 7.48% | ||
| 5 | FRANKLIN RESOURCES INC | 670,200 | 8,498,000 | 6.53% | ||
| 6 | BLACKROCK ADVISORS LLC | 456,932 | 5,794,000 | 4.46% | ||
| 7 | PointState Capital LP | 375,000 | 4,755,000 | 3.66% | ||
| 8 | WELLINGTON MANAGEMENT GROUP LLP | 242,419 | 3,074,000 | 2.36% | ||
| 9 | BlackRock Fund Advisors | 189,069 | 2,397,000 | 1.84% | ||
| 10 | BAKER BROS. ADVISORS LP | 153,350 | 1,944,000 | 1.49% | ||
| 11 | BlackRock Group LTD | 151,086 | 1,916,000 | 1.47% | ||
| 12 | Cormorant Asset Management, LP | 150,000 | 1,902,000 | 1.46% | ||
| 13 | VANGUARD GROUP INC | 145,523 | 1,845,000 | 1.42% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 139,168 | 1,765,000 | 1.36% | ||
| 15 | CADIAN CAPITAL MANAGEMENT, LP | 120,000 | 1,522,000 | 1.17% | ||
| 16 | DRIEHAUS CAPITAL MANAGEMENT LLC | 95,722 | 1,214,000 | 0.93% | ||
| 17 | STATE STREET CORP | 94,668 | 1,199,000 | 0.92% | ||
| 18 | SECTORAL ASSET MANAGEMENT INC | 89,300 | 1,132,000 | 0.87% | ||
| 19 | NORTHERN TRUST CORP | 85,633 | 1,086,000 | 0.84% | ||
| 20 | MILLENNIUM MANAGEMENT LLC | 83,973 | 1,065,000 | 0.82% | ||
| 21 | CITIGROUP INC | 68,097 | 863,000 | 0.66% | ||
| 22 | BlackRock Finance, Inc. | 64,400 | 817,000 | 0.63% | ||
| 23 | Alyeska Investment Group, L.P. | 56,937 | 722,000 | 0.56% | ||
| 24 | Nicholas Investment Partners, LP | 49,341 | 626,000 | 0.48% | ||
| 25 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 41,312 | 523,000 | 0.40% | ||
| 26 | Bank of New York Mellon Corp | 40,472 | 512,000 | 0.39% | ||
| 27 | BlackRock Investment Management, LLC | 39,700 | 503,000 | 0.39% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 38,942 | 493,000 | 0.38% | ||
| 29 | Spark Investment Management LLC | 38,400 | 486,000 | 0.37% | ||
| 30 | A.R.T. Advisors, LLC | 35,597 | 451,000 | 0.35% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,584 | 426,000 | 0.33% | ||
| 32 | WELLS FARGO & COMPANY/MN | 28,225 | 358,000 | 0.28% | ||
| 33 | Partner Investment Management, L.P. | 23,660 | 300,000 | 0.23% | ||
| 34 | TFS CAPITAL LLC | 22,472 | 285,000 | 0.22% | ||
| 35 | ROYAL BANK OF CANADA | 20,322 | 258,000 | 0.20% | ||
| 36 | CITADEL ADVISORS LLC | 18,310 | 233,000 | 0.18% | ||
| 37 | CREDIT SUISSE AG/ | 17,364 | 220,000 | 0.17% | ||
| 38 | STRS OHIO | 15,700 | 199,000 | 0.15% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,684 | 186,000 | 0.14% | ||
| 40 | PDT Partners, LLC | 12,914 | 164,000 | 0.13% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,700 | 149,000 | 0.11% | ||
| 42 | TEACHERS ADVISORS, LLC | 11,418 | 145,000 | 0.11% | ||
| 43 | DEUTSCHE BANK AG\ | 10,244 | 128,000 | 0.10% | ||
| 44 | Nationwide Fund Advisors | 6,209 | 79,000 | 0.06% | ||
| 45 | AMERICAN INTERNATIONAL GROUP, INC. | 5,229 | 66,304 | 0.05% | ||
| 46 | ALLIANCEBERNSTEIN L.P. | 5,200 | 66,000 | 0.05% | ||
| 47 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 5,083 | 64,000 | 0.05% | ||
| 48 | BANK OF AMERICA CORP /DE/ | 4,400 | 56,000 | 0.04% | ||
| 49 | BlackRock Japan Co. Ltd | 3,914 | 50,000 | 0.04% | ||
| 50 | BARCLAYS PLC | 1,550 | 18,000 | 0.01% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
