| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,201,183 | 92,386,000 | 15.10% | ||
| 2 | TPG Group Holdings (SBS) Advisors, Inc. | 2,488,533 | 71,819,000 | 11.74% | ||
| 3 | ALLIANCEBERNSTEIN L.P. | 1,324,381 | 38,222,000 | 6.25% | ||
| 4 | EAGLE ASSET MANAGEMENT INC | 1,127,233 | 32,531,000 | 5.32% | ||
| 5 | SECTORAL ASSET MANAGEMENT INC | 1,072,437 | 30,951,000 | 5.06% | ||
| 6 | STATE STREET CORP | 994,985 | 28,718,000 | 4.69% | ||
| 7 | BAKER BROS. ADVISORS LP | 879,581 | 25,385,000 | 4.15% | ||
| 8 | FMR LLC | 767,978 | 22,164,000 | 3.62% | ||
| 9 | BlackRock Fund Advisors | 754,562 | 21,777,000 | 3.56% | ||
| 10 | CITADEL ADVISORS LLC | 754,464 | 21,773,000 | 3.56% | ||
| 11 | BLACKROCK ADVISORS LLC | 678,171 | 19,572,000 | 3.20% | ||
| 12 | New Leaf Venture Partners, L.L.C. | 633,293 | 18,277,000 | 2.99% | ||
| 13 | Invesco Ltd. | 607,533 | 17,533,000 | 2.87% | ||
| 14 | VANGUARD GROUP INC | 592,609 | 17,103,000 | 2.80% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 487,290 | 14,063,000 | 2.30% | ||
| 16 | Point72 Asset Management, L.P. | 419,233 | 12,099,000 | 1.98% | ||
| 17 | GOLDMAN SACHS GROUP INC | 374,695 | 10,813,000 | 1.77% | ||
| 18 | BlackRock Group LTD | 319,798 | 9,229,000 | 1.51% | ||
| 19 | Cormorant Asset Management, LP | 317,475 | 9,162,000 | 1.50% | ||
| 20 | WELLINGTON MANAGEMENT GROUP LLP | 228,169 | 6,585,000 | 1.08% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 207,825 | 5,998,000 | 0.98% | ||
| 22 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 206,040 | 5,946,000 | 0.97% | ||
| 23 | Numeric Investors LLC | 157,929 | 4,558,000 | 0.75% | ||
| 24 | LORD, ABBETT & CO. LLC | 155,063 | 4,475,000 | 0.73% | ||
| 25 | SPHERA FUNDS MANAGEMENT LTD. | 150,000 | 4,329,000 | 0.71% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 150,000 | 4,329,000 | 0.71% | ||
| 27 | Polar Capital LLP | 128,461 | 3,707,000 | 0.61% | ||
| 28 | TEACHERS ADVISORS, LLC | 128,342 | 3,704,000 | 0.61% | ||
| 29 | BlackRock Finance, Inc. | 117,202 | 3,383,000 | 0.55% | ||
| 30 | NORTHERN TRUST CORP | 113,476 | 3,274,000 | 0.54% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 107,911 | 3,114,000 | 0.51% | ||
| 32 | MORGAN STANLEY | 99,735 | 2,879,000 | 0.47% | ||
| 33 | DRIEHAUS CAPITAL MANAGEMENT LLC | 97,426 | 2,812,000 | 0.46% | ||
| 34 | MANAGED ACCOUNT ADVISORS LLC | 75,392 | 2,176,000 | 0.36% | ||
| 35 | AMERICAN CENTURY COMPANIES INC | 75,336 | 2,174,000 | 0.36% | ||
| 36 | Spark Investment Management LLC | 74,900 | 2,161,000 | 0.35% | ||
| 37 | D. E. Shaw & Co., Inc. | 71,458 | 2,062,000 | 0.34% | ||
| 38 | TFS CAPITAL LLC | 66,681 | 1,924,000 | 0.31% | ||
| 39 | BlackRock Investment Management, LLC | 64,857 | 1,872,000 | 0.31% | ||
| 40 | Bank of New York Mellon Corp | 64,506 | 1,861,000 | 0.30% | ||
| 41 | WELLS FARGO & COMPANY/MN | 58,555 | 1,690,000 | 0.28% | ||
| 42 | Nicholas Investment Partners, LP | 55,763 | 1,609,000 | 0.26% | ||
| 43 | PICTET ASSET MANAGEMENT LTD | 62,700 | 1,599,000 | 0.26% | ||
| 44 | CADIAN CAPITAL MANAGEMENT, LP | 55,000 | 1,587,000 | 0.26% | ||
| 45 | SABBY MANAGEMENT, LLC | 46,800 | 1,351,000 | 0.22% | ||
| 46 | PDT Partners, LLC | 41,400 | 1,195,000 | 0.20% | ||
| 47 | PNC FINANCIAL SERVICES GROUP, INC. | 37,780 | 1,090,000 | 0.18% | ||
| 48 | CREDIT SUISSE AG/ | 36,460 | 1,052,000 | 0.17% | ||
| 49 | Informed Momentum Co LLC | 35,136 | 1,014,000 | 0.17% | ||
| 50 | TIAA CREF INVESTMENT MANAGEMENT LLC | 33,573 | 969,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
