| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 3,201,183 | 93,122,000 | 30.91% | ||
| 2 | JENNISON ASSOCIATES LLC | 1,183,908 | 34,440,000 | 11.43% | ||
| 3 | FRANKLIN RESOURCES INC | 629,472 | 18,311,000 | 6.08% | ||
| 4 | BlackRock Fund Advisors | 583,582 | 16,976,000 | 5.64% | ||
| 5 | CITADEL ADVISORS LLC | 419,253 | 12,195,000 | 4.05% | ||
| 6 | BLACKROCK ADVISORS LLC | 398,942 | 11,605,000 | 3.85% | ||
| 7 | FMR LLC | 367,978 | 10,704,000 | 3.55% | ||
| 8 | PFM Health Sciences, LP | 329,948 | 9,598,000 | 3.19% | ||
| 9 | WELLINGTON MANAGEMENT GROUP LLP | 308,189 | 8,965,000 | 2.98% | ||
| 10 | Cormorant Asset Management, LP | 250,000 | 7,273,000 | 2.41% | ||
| 11 | VANGUARD GROUP INC | 233,730 | 6,799,000 | 2.26% | ||
| 12 | New Leaf Venture Partners, L.L.C. | 223,553 | 6,503,000 | 2.16% | ||
| 13 | GOLDMAN SACHS GROUP INC | 212,349 | 6,177,000 | 2.05% | ||
| 14 | PointState Capital LP | 175,000 | 5,091,000 | 1.69% | ||
| 15 | BAKER BROS. ADVISORS LP | 153,350 | 4,461,000 | 1.48% | ||
| 16 | BlackRock Group LTD | 144,700 | 4,209,000 | 1.40% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 138,561 | 4,031,000 | 1.34% | ||
| 18 | SECTORAL ASSET MANAGEMENT INC | 104,300 | 3,034,000 | 1.01% | ||
| 19 | STATE STREET CORP | 101,062 | 2,943,000 | 0.98% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 98,830 | 2,875,000 | 0.95% | ||
| 21 | NORTHERN TRUST CORP | 83,885 | 2,440,000 | 0.81% | ||
| 22 | EverPoint Asset Management, LLC | 83,527 | 2,430,000 | 0.81% | ||
| 23 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 79,585 | 2,315,000 | 0.77% | ||
| 24 | BlackRock Finance, Inc. | 64,602 | 1,879,000 | 0.62% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 52,727 | 1,533,000 | 0.51% | ||
| 26 | Nicholas Investment Partners, LP | 49,438 | 1,438,000 | 0.48% | ||
| 27 | Bank of New York Mellon Corp | 48,266 | 1,404,000 | 0.47% | ||
| 28 | TFS CAPITAL LLC | 44,505 | 1,295,000 | 0.43% | ||
| 29 | Spark Investment Management LLC | 43,300 | 1,256,000 | 0.42% | ||
| 30 | RUSSELL FRANK CO/ | 42,408 | 1,229,000 | 0.41% | ||
| 31 | Informed Momentum Co LLC | 40,331 | 1,173,000 | 0.39% | ||
| 32 | BlackRock Investment Management, LLC | 40,180 | 1,169,000 | 0.39% | ||
| 33 | Invesco Ltd. | 38,004 | 1,106,000 | 0.37% | ||
| 34 | A.R.T. Advisors, LLC | 37,567 | 1,092,000 | 0.36% | ||
| 35 | TIAA CREF INVESTMENT MANAGEMENT LLC | 28,540 | 830,000 | 0.28% | ||
| 36 | STRS OHIO | 26,100 | 759,000 | 0.25% | ||
| 37 | Polar Capital LLP | 25,596 | 745,000 | 0.25% | ||
| 38 | Neuberger Berman Group LLC | 22,450 | 653,000 | 0.22% | ||
| 39 | ProShare Advisors LLC | 22,121 | 643,000 | 0.21% | ||
| 40 | MILLENNIUM MANAGEMENT LLC | 15,422 | 449,000 | 0.15% | ||
| 41 | ELLINGTON MANAGEMENT GROUP LLC | 15,200 | 442,000 | 0.15% | ||
| 42 | CREDIT SUISSE AG/ | 15,064 | 439,000 | 0.15% | ||
| 43 | ROYAL BANK OF CANADA | 15,045 | 438,000 | 0.15% | ||
| 44 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,747 | 429,000 | 0.14% | ||
| 45 | PDT Partners, LLC | 12,202 | 355,000 | 0.12% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 11,700 | 341,000 | 0.11% | ||
| 47 | TEACHERS ADVISORS, LLC | 11,418 | 332,000 | 0.11% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 11,032 | 321,000 | 0.11% | ||
| 49 | D. E. Shaw & Co., Inc. | 9,810 | 285,000 | 0.09% | ||
| 50 | Point72 Asset Management, L.P. | 9,300 | 271,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
