| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,365,072 | 337,158,000 | 21.01% | ||
| 2 | Novo Holdings A/S | 1,951,183 | 103,354,000 | 6.44% | ||
| 3 | MILLENNIUM MANAGEMENT LLC | 1,472,425 | 77,994,000 | 4.86% | ||
| 4 | EAGLE ASSET MANAGEMENT INC | 1,386,970 | 73,467,000 | 4.58% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 1,320,109 | 69,926,000 | 4.36% | ||
| 6 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 65,605,000 | 4.09% | ||
| 7 | VANGUARD GROUP INC | 1,227,483 | 65,020,000 | 4.05% | ||
| 8 | BB BIOTECH AG | 1,155,150 | 61,188,000 | 3.81% | ||
| 9 | BlackRock Fund Advisors | 978,637 | 51,838,000 | 3.23% | ||
| 10 | AMUNDI ASSET MANAGEMENT US, INC. | 934,777 | 49,515,000 | 3.09% | ||
| 11 | BAKER BROS. ADVISORS LP | 891,688 | 47,233,000 | 2.94% | ||
| 12 | JANUS HENDERSON INVESTORS US LLC | 863,315 | 45,730,000 | 2.85% | ||
| 13 | Point72 Asset Management, L.P. | 819,400 | 43,404,000 | 2.70% | ||
| 14 | Cormorant Asset Management, LP | 757,475 | 40,123,000 | 2.50% | ||
| 15 | PFM Health Sciences, LP | 753,281 | 39,901,000 | 2.49% | ||
| 16 | BLACKROCK ADVISORS LLC | 685,744 | 36,324,000 | 2.26% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 682,736 | 36,165,000 | 2.25% | ||
| 18 | Invesco Ltd. | 600,642 | 31,817,000 | 1.98% | ||
| 19 | CITADEL ADVISORS LLC | 572,552 | 30,328,000 | 1.89% | ||
| 20 | CADIAN CAPITAL MANAGEMENT, LP | 425,000 | 22,512,000 | 1.40% | ||
| 21 | BlackRock Group LTD | 336,924 | 17,848,000 | 1.11% | ||
| 22 | BlackRock Institutional Trust Company, N.A. | 325,067 | 17,219,000 | 1.07% | ||
| 23 | GOLDMAN SACHS GROUP INC | 317,373 | 16,811,000 | 1.05% | ||
| 24 | MORGAN STANLEY | 258,924 | 13,716,000 | 0.85% | ||
| 25 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 250,000 | 13,242,500 | 0.83% | ||
| 26 | AXA S.A. | 189,435 | 10,034,000 | 0.63% | ||
| 27 | TEACHERS ADVISORS, LLC | 171,922 | 9,107,000 | 0.57% | ||
| 28 | PointState Capital LP | 150,000 | 7,946,000 | 0.50% | ||
| 29 | UBS Group AG | 135,603 | 7,183,000 | 0.45% | ||
| 30 | NORTHERN TRUST CORP | 128,815 | 6,824,000 | 0.43% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 125,000 | 6,621,000 | 0.41% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 122,897 | 6,509,000 | 0.41% | ||
| 33 | Bank of New York Mellon Corp | 122,855 | 6,508,000 | 0.41% | ||
| 34 | RENAISSANCE TECHNOLOGIES LLC | 118,300 | 6,266,000 | 0.39% | ||
| 35 | BlackRock Finance, Inc. | 112,955 | 5,983,000 | 0.37% | ||
| 36 | BlackRock Investment Management, LLC | 107,298 | 5,684,000 | 0.35% | ||
| 37 | MONASHEE INVESTMENT MANAGEMENT LLC | 100,000 | 5,297,000 | 0.33% | PRN | |
| 38 | Asset Management One Co., Ltd. | 106,304 | 4,989,000 | 0.31% | ||
| 39 | Numeric Investors LLC | 92,000 | 4,873,000 | 0.30% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,400 | 4,736,000 | 0.30% | Put | |
| 41 | DEUTSCHE BANK AG\ | 88,953 | 4,708,000 | 0.29% | ||
| 42 | DRIEHAUS CAPITAL MANAGEMENT LLC | 81,407 | 4,312,000 | 0.27% | ||
| 43 | MANAGED ACCOUNT ADVISORS LLC | 73,715 | 3,905,000 | 0.24% | ||
| 44 | BROWN ADVISORY INC | 72,336 | 3,832,000 | 0.24% | ||
| 45 | WELLS FARGO & COMPANY/MN | 70,924 | 3,758,000 | 0.23% | ||
| 46 | TIAA CREF INVESTMENT MANAGEMENT LLC | 70,023 | 3,709,000 | 0.23% | ||
| 47 | AMERICAN CENTURY COMPANIES INC | 62,983 | 3,336,000 | 0.21% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 62,209 | 3,295,000 | 0.21% | ||
| 49 | CREDIT SUISSE AG/ | 57,254 | 3,032,000 | 0.19% | ||
| 50 | PDT Partners, LLC | 53,358 | 2,826,000 | 0.18% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
