| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,034,846 | 197,701,000 | 16.63% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,239,855 | 138,900,000 | 11.68% | ||
| 3 | VANGUARD GROUP INC | 1,845,168 | 60,448,000 | 5.09% | ||
| 4 | BB BIOTECH AG | 1,510,150 | 49,473,000 | 4.16% | ||
| 5 | MILLENNIUM MANAGEMENT LLC | 1,505,099 | 49,307,000 | 4.15% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 1,480,526 | 48,502,000 | 4.08% | ||
| 7 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 40,574,000 | 3.41% | ||
| 8 | Point72 Asset Management, L.P. | 1,189,700 | 38,975,000 | 3.28% | ||
| 9 | BlackRock Fund Advisors | 1,173,654 | 38,449,000 | 3.23% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 1,160,231 | 38,009,000 | 3.20% | ||
| 11 | PFM Health Sciences, LP | 1,105,911 | 36,230,000 | 3.05% | ||
| 12 | AMUNDI ASSET MANAGEMENT US, INC. | 982,107 | 32,174,000 | 2.71% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 762,682 | 24,985,000 | 2.10% | ||
| 14 | Cormorant Asset Management, LP | 757,475 | 24,815,000 | 2.09% | ||
| 15 | ALPS ADVISORS INC | 68,106 | 22,312,000 | 1.88% | ||
| 16 | Invesco Ltd. | 665,173 | 21,791,000 | 1.83% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 588,809 | 19,289,000 | 1.62% | ||
| 18 | BLACKROCK ADVISORS LLC | 562,208 | 18,418,000 | 1.55% | ||
| 19 | SENZAR ASSET MANAGEMENT, LLC | 549,900 | 18,014,724 | 1.52% | ||
| 20 | BAKER BROS. ADVISORS LP | 513,439 | 16,820,000 | 1.41% | ||
| 21 | CITADEL ADVISORS LLC | 494,295 | 16,193,000 | 1.36% | ||
| 22 | CADIAN CAPITAL MANAGEMENT, LP | 389,700 | 12,767,000 | 1.07% | ||
| 23 | GOLDMAN SACHS GROUP INC | 381,026 | 12,483,000 | 1.05% | ||
| 24 | EverPoint Asset Management, LLC | 370,000 | 12,121,000 | 1.02% | ||
| 25 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 320,683 | 10,505,000 | 0.88% | ||
| 26 | BlackRock Group LTD | 299,901 | 9,825,000 | 0.83% | ||
| 27 | NORTHERN TRUST CORP | 255,063 | 8,357,000 | 0.70% | ||
| 28 | AXA S.A. | 244,509 | 8,010,000 | 0.67% | ||
| 29 | Asset Management One Co., Ltd. | 269,438 | 7,924,000 | 0.67% | ||
| 30 | MORGAN STANLEY | 232,272 | 7,610,000 | 0.64% | ||
| 31 | JPMORGAN CHASE & CO | 223,918 | 7,335,000 | 0.62% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 185,041 | 6,061,000 | 0.51% | ||
| 33 | BROWN ADVISORY INC | 173,471 | 5,683,000 | 0.48% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 167,100 | 5,474,000 | 0.46% | Put | |
| 35 | NORGES BANK | 153,339 | 5,023,000 | 0.42% | ||
| 36 | TEACHERS ADVISORS, LLC | 146,205 | 4,790,000 | 0.40% | ||
| 37 | SPHERA FUNDS MANAGEMENT LTD. | 125,000 | 4,095,000 | 0.34% | ||
| 38 | PRICE T ROWE ASSOCIATES INC /MD/ | 122,638 | 4,018,000 | 0.34% | ||
| 39 | Bank of New York Mellon Corp | 120,151 | 3,936,000 | 0.33% | ||
| 40 | UBS Group AG | 115,181 | 3,773,000 | 0.32% | ||
| 41 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 112,926 | 3,699,000 | 0.31% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 112,036 | 3,670,000 | 0.31% | ||
| 43 | BlackRock Investment Management, LLC | 108,817 | 3,565,000 | 0.30% | ||
| 44 | MARSHALL WACE, LLP | 108,105 | 3,541,000 | 0.30% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,783 | 3,465,000 | 0.29% | ||
| 46 | Numeric Investors LLC | 100,400 | 3,289,000 | 0.28% | ||
| 47 | HBK INVESTMENTS L P | 98,700 | 3,233,000 | 0.27% | ||
| 48 | Apex Capital Management | 95,413 | 3,126,000 | 0.26% | ||
| 49 | CREDIT SUISSE AG/ | 93,665 | 3,069,000 | 0.26% | ||
| 50 | BlackRock Finance, Inc. | 83,855 | 2,747,000 | 0.23% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
