| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,444,124 | 212,849,000 | 16.18% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,881,195 | 161,221,000 | 12.25% | ||
| 3 | VANGUARD GROUP INC | 2,149,724 | 71,006,000 | 5.40% | ||
| 4 | PFM Health Sciences, LP | 1,890,030 | 62,428,000 | 4.74% | ||
| 5 | BB BIOTECH AG | 1,510,150 | 49,880,000 | 3.79% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 1,477,129 | 48,391,000 | 3.68% | ||
| 7 | WELLINGTON MANAGEMENT GROUP LLP | 1,353,755 | 44,715,000 | 3.40% | ||
| 8 | Point72 Asset Management, L.P. | 1,283,800 | 42,404,000 | 3.22% | ||
| 9 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 40,909,000 | 3.11% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 1,196,505 | 39,520,000 | 3.00% | ||
| 11 | BlackRock Fund Advisors | 1,090,915 | 36,033,000 | 2.74% | ||
| 12 | STATE STREET CORP | 995,234 | 32,876,000 | 2.50% | ||
| 13 | SECTORAL ASSET MANAGEMENT INC | 934,951 | 30,881,000 | 2.35% | ||
| 14 | MILLENNIUM MANAGEMENT LLC | 788,913 | 26,058,000 | 1.98% | ||
| 15 | Cormorant Asset Management, LP | 757,475 | 25,019,000 | 1.90% | ||
| 16 | Invesco Ltd. | 676,122 | 22,332,000 | 1.70% | ||
| 17 | EverPoint Asset Management, LLC | 600,000 | 19,818,000 | 1.51% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 599,808 | 19,812,000 | 1.51% | ||
| 19 | AMUNDI ASSET MANAGEMENT US, INC. | 577,014 | 19,059,000 | 1.45% | ||
| 20 | GOLDMAN SACHS GROUP INC | 562,102 | 18,566,000 | 1.41% | ||
| 21 | SENZAR ASSET MANAGEMENT, LLC | 557,170 | 18,403,325 | 1.40% | ||
| 22 | BLACKROCK ADVISORS LLC | 541,051 | 17,871,000 | 1.36% | ||
| 23 | Foresite Capital Management II, LLC | 419,997 | 13,873,000 | 1.05% | ||
| 24 | CADIAN CAPITAL MANAGEMENT, LP | 389,700 | 12,872,000 | 0.98% | ||
| 25 | BROWN ADVISORY INC | 379,579 | 12,538,000 | 0.95% | ||
| 26 | Asset Management One Co., Ltd. | 360,925 | 12,520,000 | 0.95% | ||
| 27 | CITADEL ADVISORS LLC | 327,887 | 10,830,000 | 0.82% | ||
| 28 | JPMORGAN CHASE & CO | 313,599 | 10,358,000 | 0.79% | ||
| 29 | NORGES BANK | 308,308 | 10,183,000 | 0.77% | ||
| 30 | BlackRock Group LTD | 295,378 | 9,757,000 | 0.74% | ||
| 31 | WELLS FARGO & COMPANY/MN | 269,774 | 8,911,000 | 0.68% | ||
| 32 | NORTHERN TRUST CORP | 262,957 | 8,686,000 | 0.66% | ||
| 33 | AXA S.A. | 257,269 | 8,498,000 | 0.65% | ||
| 34 | FORESITE CAPITAL MANAGEMENT III, LLC | 229,895 | 7,593,000 | 0.58% | ||
| 35 | APEX CAPITAL, LLC | 227,200 | 7,504,000 | 0.57% | ||
| 36 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 216,393 | 7,147,000 | 0.54% | ||
| 37 | MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 185,798 | 6,137,000 | 0.47% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 175,616 | 5,800,000 | 0.44% | ||
| 39 | AMERIPRISE FINANCIAL INC | 124,143 | 4,100,000 | 0.31% | ||
| 40 | Bank of New York Mellon Corp | 123,051 | 4,065,000 | 0.31% | ||
| 41 | PRICE T ROWE ASSOCIATES INC /MD/ | 122,698 | 4,053,000 | 0.31% | ||
| 42 | BANK OF AMERICA CORP /DE/ | 122,260 | 4,038,000 | 0.31% | ||
| 43 | CREDIT SUISSE AG/ | 113,997 | 3,767,000 | 0.29% | ||
| 44 | TEACHERS ADVISORS, LLC | 113,545 | 3,750,000 | 0.29% | ||
| 45 | SPHERA FUNDS MANAGEMENT LTD. | 112,500 | 3,716,000 | 0.28% | ||
| 46 | BlackRock Investment Management, LLC | 109,825 | 3,628,000 | 0.28% | ||
| 47 | Apex Capital Management | 102,679 | 3,391,000 | 0.26% | ||
| 48 | PRUDENTIAL FINANCIAL INC | 92,500 | 3,055,000 | 0.23% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 87,548 | 2,892,000 | 0.22% | ||
| 50 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 81,300 | 2,685,000 | 0.20% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
