| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,527,732 | 246,684,000 | 14.31% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 4,568,883 | 149,723,000 | 8.69% | ||
| 3 | WELLINGTON MANAGEMENT GROUP LLP | 3,836,272 | 125,714,000 | 7.29% | ||
| 4 | VANGUARD GROUP INC | 3,153,148 | 103,329,000 | 6.00% | ||
| 5 | PFM Health Sciences, LP | 2,007,664 | 65,791,000 | 3.82% | ||
| 6 | BlackRock Fund Advisors | 1,854,944 | 60,787,000 | 3.53% | ||
| 7 | Cormorant Asset Management, LP | 1,689,071 | 55,351,000 | 3.21% | ||
| 8 | BB BIOTECH AG | 1,685,150 | 55,222,000 | 3.20% | ||
| 9 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,585,683 | 51,963,000 | 3.01% | ||
| 10 | STATE STREET CORP | 1,490,500 | 48,843,000 | 2.83% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 1,327,562 | 43,504,000 | 2.52% | ||
| 12 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 40,587,000 | 2.35% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 1,121,086 | 36,738,000 | 2.13% | ||
| 14 | EAGLE ASSET MANAGEMENT INC | 1,114,538 | 36,523,000 | 2.12% | ||
| 15 | Senator Investment Group LP | 1,000,000 | 32,770,000 | 1.90% | ||
| 16 | AMUNDI ASSET MANAGEMENT US, INC. | 935,441 | 30,654,000 | 1.78% | ||
| 17 | CITADEL ADVISORS LLC | 836,124 | 27,400,000 | 1.59% | ||
| 18 | Foresite Capital Management II, LLC | 802,724 | 26,305,000 | 1.53% | ||
| 19 | GOLDMAN SACHS GROUP INC | 705,207 | 23,110,000 | 1.34% | ||
| 20 | Redmile Group, LLC | 702,539 | 23,022,000 | 1.34% | ||
| 21 | NORTHERN TRUST CORP | 549,157 | 17,996,000 | 1.04% | ||
| 22 | SECTORAL ASSET MANAGEMENT INC | 537,121 | 17,601,000 | 1.02% | ||
| 23 | MARSHALL WACE, LLP | 526,142 | 17,242,000 | 1.00% | ||
| 24 | BROWN ADVISORY INC | 459,912 | 15,072,000 | 0.87% | ||
| 25 | WESTFIELD CAPITAL MANAGEMENT CO LP | 403,075 | 13,209,000 | 0.77% | ||
| 26 | PERCEPTIVE ADVISORS LLC | 391,280 | 12,822,000 | 0.74% | ||
| 27 | Invesco Ltd. | 384,005 | 12,584,000 | 0.73% | ||
| 28 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 346,409 | 11,352,000 | 0.66% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 326,726 | 10,706,000 | 0.62% | ||
| 30 | SENZAR ASSET MANAGEMENT, LLC | 296,670 | 9,721,876 | 0.56% | ||
| 31 | Asset Management One Co., Ltd. | 309,500 | 9,687,000 | 0.56% | ||
| 32 | PRICE T ROWE ASSOCIATES INC /MD/ | 290,446 | 9,518,000 | 0.55% | ||
| 33 | BLACKROCK ADVISORS LLC | 285,470 | 9,355,000 | 0.54% | ||
| 34 | GOLDMAN SACHS GROUP INC | 280,000 | 9,176,000 | 0.53% | Put | |
| 35 | WELLS FARGO & COMPANY/MN | 262,182 | 8,591,000 | 0.50% | ||
| 36 | AXA S.A. | 261,690 | 8,576,000 | 0.50% | ||
| 37 | NORGES BANK | 262,153 | 8,205,000 | 0.48% | ||
| 38 | FRANKLIN RESOURCES INC | 250,000 | 8,193,000 | 0.48% | ||
| 39 | CADIAN CAPITAL MANAGEMENT, LP | 240,665 | 7,887,000 | 0.46% | ||
| 40 | DRIEHAUS CAPITAL MANAGEMENT LLC | 232,874 | 7,631,000 | 0.44% | ||
| 41 | New Leaf Venture Partners, L.L.C. | 230,954 | 7,568,000 | 0.44% | ||
| 42 | BAKER BROS. ADVISORS LP | 217,328 | 7,122,000 | 0.41% | ||
| 43 | Bank of New York Mellon Corp | 211,401 | 6,928,000 | 0.40% | ||
| 44 | CREDIT SUISSE AG/ | 202,839 | 6,648,000 | 0.39% | ||
| 45 | Fiera Capital Corp | 196,709 | 6,447,000 | 0.37% | ||
| 46 | ROYAL BANK OF CANADA | 196,334 | 6,434,000 | 0.37% | ||
| 47 | AMERIPRISE FINANCIAL INC | 194,062 | 6,360,000 | 0.37% | ||
| 48 | PICTET ASSET MANAGEMENT LTD | 192,636 | 6,313,000 | 0.37% | ||
| 49 | BlackRock Investment Management, LLC | 188,670 | 6,183,000 | 0.36% | ||
| 50 | DEUTSCHE BANK AG\ | 183,825 | 6,022,000 | 0.35% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
