| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 7,476,984 | 155,521,000 | 14.07% | ||
| 2 | JANUS HENDERSON INVESTORS US LLC | 5,167,085 | 107,473,000 | 9.72% | ||
| 3 | BlackRock Finance, Inc. | 3,956,052 | 82,285,000 | 7.44% | ||
| 4 | WELLINGTON MANAGEMENT GROUP LLP | 3,640,788 | 75,728,000 | 6.85% | ||
| 5 | VANGUARD GROUP INC | 3,438,702 | 71,524,000 | 6.47% | ||
| 6 | Redmile Group, LLC | 1,909,886 | 39,726,000 | 3.59% | ||
| 7 | STATE STREET CORP | 1,777,113 | 36,966,000 | 3.34% | ||
| 8 | BB BIOTECH AG | 1,685,150 | 35,051,000 | 3.17% | ||
| 9 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,629,222 | 33,888,000 | 3.07% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 1,429,799 | 29,740,000 | 2.69% | ||
| 11 | TPG Group Holdings (SBS) Advisors, Inc. | 1,238,533 | 25,761,000 | 2.33% | ||
| 12 | EAGLE ASSET MANAGEMENT INC | 1,155,265 | 24,029,000 | 2.17% | ||
| 13 | Cormorant Asset Management, LP | 1,098,205 | 22,843,000 | 2.07% | ||
| 14 | PFM Health Sciences, LP | 1,045,181 | 21,740,000 | 1.97% | ||
| 15 | Foresite Capital Management II, LLC | 956,041 | 19,886,000 | 1.80% | ||
| 16 | AMUNDI ASSET MANAGEMENT US, INC. | 783,889 | 16,305,000 | 1.47% | ||
| 17 | SECTORAL ASSET MANAGEMENT INC | 713,119 | 14,833,000 | 1.34% | ||
| 18 | GOLDMAN SACHS GROUP INC | 669,085 | 13,917,000 | 1.26% | ||
| 19 | PICTET ASSET MANAGEMENT LTD | 611,706 | 12,724,000 | 1.15% | ||
| 20 | EMERALD ADVISERS, LLC | 601,832 | 12,518,000 | 1.13% | ||
| 21 | NORTHERN TRUST CORP | 557,747 | 11,600,000 | 1.05% | ||
| 22 | BROWN ADVISORY INC | 525,128 | 10,923,000 | 0.99% | ||
| 23 | CITADEL ADVISORS LLC | 467,387 | 9,722,000 | 0.88% | ||
| 24 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 416,052 | 8,820,000 | 0.80% | ||
| 25 | PRICE T ROWE ASSOCIATES INC /MD/ | 418,129 | 8,697,000 | 0.79% | ||
| 26 | EMERALD MUTUAL FUND ADVISERS TRUST | 417,963 | 8,694,000 | 0.79% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 401,570 | 8,352,000 | 0.76% | ||
| 28 | WESTFIELD CAPITAL MANAGEMENT CO LP | 397,350 | 8,265,000 | 0.75% | ||
| 29 | Invesco Ltd. | 392,535 | 8,165,000 | 0.74% | ||
| 30 | PERCEPTIVE ADVISORS LLC | 384,169 | 7,991,000 | 0.72% | ||
| 31 | AXA S.A. | 343,193 | 7,138,000 | 0.65% | ||
| 32 | Artal Group S.A. | 300,000 | 6,240,000 | 0.56% | ||
| 33 | MORGAN STANLEY | 255,005 | 5,305,000 | 0.48% | ||
| 34 | FRANKLIN RESOURCES INC | 244,600 | 5,088,000 | 0.46% | ||
| 35 | CREDIT SUISSE AG/ | 243,807 | 5,071,000 | 0.46% | ||
| 36 | New Leaf Venture Partners, L.L.C. | 228,428 | 4,751,000 | 0.43% | ||
| 37 | DAFNA Capital Management LLC | 221,013 | 4,597,000 | 0.42% | ||
| 38 | BAKER BROS. ADVISORS LP | 217,328 | 4,520,000 | 0.41% | ||
| 39 | SENZAR ASSET MANAGEMENT, LLC | 215,070 | 4,473,000 | 0.40% | ||
| 40 | MARSHALL WACE ASIA LTD | 211,913 | 4,450,000 | 0.40% | ||
| 41 | MARSHALL WACE NORTH AMERICA, L.P. | 211,913 | 4,450,000 | 0.40% | ||
| 42 | NORGES BANK | 212,213 | 4,414,000 | 0.40% | ||
| 43 | Bank of New York Mellon Corp | 210,401 | 4,377,000 | 0.40% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 209,273 | 4,353,000 | 0.39% | ||
| 45 | MACQUARIE GROUP LTD | 202,613 | 4,214,000 | 0.38% | ||
| 46 | ROYAL BANK OF CANADA | 190,253 | 3,958,000 | 0.36% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 183,517 | 3,817,000 | 0.35% | ||
| 48 | Rock Springs Capital Management LP | 182,000 | 3,786,000 | 0.34% | ||
| 49 | SAMLYN CAPITAL, LLC | 181,143 | 3,768,000 | 0.34% | ||
| 50 | Fiera Capital Corp | 162,076 | 3,371,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
