| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 226,894,000 | 31.83% | ||
| 2 | BB BIOTECH AG | 2,752,140 | 107,086,000 | 15.02% | ||
| 3 | Bain Capital Public Equity Management, LLC | 2,057,497 | 80,057,000 | 11.23% | ||
| 4 | WELLCOME TRUST LTD (THE) as trustee of the WELLCOME TRUST | 1,729,091 | 67,279,000 | 9.44% | ||
| 5 | FMR LLC | 1,656,163 | 64,441,000 | 9.04% | ||
| 6 | CITADEL ADVISORS LLC | 686,127 | 26,697,000 | 3.75% | ||
| 7 | BlackRock Fund Advisors | 600,894 | 23,381,000 | 3.28% | ||
| 8 | FRANKLIN RESOURCES INC | 416,200 | 16,194,000 | 2.27% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 395,000 | 15,369,000 | 2.16% | ||
| 10 | Point72 Asset Management, L.P. | 336,200 | 13,082,000 | 1.84% | ||
| 11 | VANGUARD GROUP INC | 275,543 | 10,721,000 | 1.50% | ||
| 12 | EverPoint Asset Management, LLC | 241,300 | 9,389,000 | 1.32% | ||
| 13 | JPMORGAN CHASE & CO | 179,825 | 6,997,000 | 0.98% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 132,149 | 5,142,000 | 0.72% | ||
| 15 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 87,954 | 3,422,000 | 0.48% | ||
| 16 | STATE STREET CORP | 85,838 | 3,344,000 | 0.47% | ||
| 17 | NORTHERN TRUST CORP | 80,948 | 3,150,000 | 0.44% | ||
| 18 | Candriam S.C.A. | 65,000 | 2,529,000 | 0.35% | ||
| 19 | Nicholas Investment Partners, LP | 61,510 | 2,393,000 | 0.34% | ||
| 20 | GEODE CAPITAL MANAGEMENT, LLC | 60,432 | 2,351,000 | 0.33% | ||
| 21 | Bank of New York Mellon Corp | 47,202 | 1,836,000 | 0.26% | ||
| 22 | J. Goldman & Co LP | 43,750 | 1,702,000 | 0.24% | ||
| 23 | A.R.T. Advisors, LLC | 41,963 | 1,632,000 | 0.23% | ||
| 24 | MORGAN STANLEY | 33,666 | 1,310,000 | 0.18% | ||
| 25 | GOLDMAN SACHS GROUP INC | 33,612 | 1,308,000 | 0.18% | ||
| 26 | Atika Capital Management LLC | 33,000 | 1,284,000 | 0.18% | ||
| 27 | RUSSELL FRANK CO/ | 32,423 | 1,261,000 | 0.18% | ||
| 28 | Informed Momentum Co LLC | 30,905 | 1,203,000 | 0.17% | ||
| 29 | CITIGROUP INC | 29,984 | 1,167,000 | 0.16% | ||
| 30 | ProShare Advisors LLC | 23,466 | 913,000 | 0.13% | ||
| 31 | BlackRock Investment Management, LLC | 22,505 | 876,000 | 0.12% | ||
| 32 | CREDIT SUISSE AG/ | 21,458 | 835,000 | 0.12% | ||
| 33 | TIAA CREF INVESTMENT MANAGEMENT LLC | 20,530 | 799,000 | 0.11% | ||
| 34 | MILLENNIUM MANAGEMENT LLC | 19,299 | 751,000 | 0.11% | ||
| 35 | BEACON FINANCIAL GROUP | 15,000 | 569,000 | 0.08% | ||
| 36 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,361 | 559,000 | 0.08% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 10,600 | 413,000 | 0.06% | ||
| 38 | BLUE ARROW CAPITAL MANAGEMENT LLC | 10,000 | 389,000 | 0.05% | ||
| 39 | Swiss National Bank | 9,700 | 377,000 | 0.05% | ||
| 40 | TEACHERS ADVISORS, LLC | 9,350 | 364,000 | 0.05% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 7,505 | 332,000 | 0.05% | ||
| 42 | Rathbones Group PLC | 8,165 | 318,000 | 0.04% | ||
| 43 | Spark Investment Management LLC | 8,000 | 311,000 | 0.04% | ||
| 44 | METROPOLITAN LIFE INSURANCE CO/NY | 6,623 | 258,000 | 0.04% | ||
| 45 | Nationwide Fund Advisors | 5,893 | 229,000 | 0.03% | ||
| 46 | SG Americas Securities, LLC | 5,815 | 226,000 | 0.03% | ||
| 47 | Creative Planning | 5,670 | 221,000 | 0.03% | ||
| 48 | Cubist Systematic Strategies, LLC | 5,600 | 218,000 | 0.03% | ||
| 49 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,893 | 190,000 | 0.03% | ||
| 50 | AMERICAN INTERNATIONAL GROUP, INC. | 4,870 | 189,492 | 0.03% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
