| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,455,651 | 237,245,000 | 14.58% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 214,299,000 | 13.17% | ||
| 3 | BB BIOTECH AG | 4,360,399 | 160,245,000 | 9.85% | ||
| 4 | Bain Capital Public Equity Management, LLC | 3,339,312 | 122,720,000 | 7.54% | ||
| 5 | VANGUARD GROUP INC | 2,615,168 | 96,107,000 | 5.91% | ||
| 6 | Tourbillon Capital Partners, L.P. | 2,278,781 | 83,745,000 | 5.15% | ||
| 7 | FARALLON CAPITAL MANAGEMENT LLC | 1,535,000 | 56,411,000 | 3.47% | ||
| 8 | BlackRock Fund Advisors | 1,354,202 | 49,767,000 | 3.06% | ||
| 9 | STATE STREET CORP | 1,291,252 | 47,452,000 | 2.92% | ||
| 10 | JENNISON ASSOCIATES LLC | 964,142 | 35,432,000 | 2.18% | ||
| 11 | Rock Springs Capital Management LP | 867,500 | 31,881,000 | 1.96% | ||
| 12 | CITADEL ADVISORS LLC | 836,180 | 30,730,000 | 1.89% | ||
| 13 | ROYAL BANK OF CANADA | 836,118 | 30,729,000 | 1.89% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 792,644 | 29,130,000 | 1.79% | ||
| 15 | DEUTSCHE BANK AG\ | 775,163 | 28,485,000 | 1.75% | ||
| 16 | PRICE T ROWE ASSOCIATES INC /MD/ | 588,571 | 21,630,000 | 1.33% | ||
| 17 | Fiera Capital Corp | 574,077 | 21,097,000 | 1.30% | ||
| 18 | WELLS FARGO & COMPANY/MN | 505,830 | 18,589,000 | 1.14% | ||
| 19 | FRANKLIN RESOURCES INC | 464,200 | 17,059,000 | 1.05% | ||
| 20 | ING GROEP NV | 431,236 | 15,848,000 | 0.97% | ||
| 21 | ALLIANCEBERNSTEIN L.P. | 430,600 | 15,825,000 | 0.97% | ||
| 22 | GOLDMAN SACHS GROUP INC | 404,053 | 14,849,000 | 0.91% | ||
| 23 | OppenheimerFunds, Inc. | 357,920 | 13,154,000 | 0.81% | ||
| 24 | NORTHERN TRUST CORP | 356,293 | 13,094,000 | 0.80% | ||
| 25 | Bank of New York Mellon Corp | 338,198 | 12,429,000 | 0.76% | ||
| 26 | NORGES BANK | 337,123 | 12,389,000 | 0.76% | ||
| 27 | GOLDMAN SACHS GROUP INC | 335,500 | 12,330,000 | 0.76% | Put | |
| 28 | BANK OF AMERICA CORP /DE/ | 274,068 | 10,072,000 | 0.62% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 241,121 | 8,861,000 | 0.54% | ||
| 30 | PICTET ASSET MANAGEMENT LTD | 216,060 | 7,834,000 | 0.48% | ||
| 31 | JPMORGAN CHASE & CO | 200,435 | 7,366,000 | 0.45% | ||
| 32 | CQS Cayman LP | 200,000 | 7,350,000 | 0.45% | ||
| 33 | CITIGROUP INC | 164,190 | 6,034,000 | 0.37% | ||
| 34 | CREDIT SUISSE AG/ | 129,251 | 4,750,000 | 0.29% | ||
| 35 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 123,310 | 4,532,000 | 0.28% | ||
| 36 | BlackRock Investment Management, LLC | 119,167 | 4,379,000 | 0.27% | ||
| 37 | Candriam S.C.A. | 115,000 | 4,226,000 | 0.26% | ||
| 38 | UBS Group AG | 114,442 | 4,205,000 | 0.26% | ||
| 39 | TIAA CREF INVESTMENT MANAGEMENT LLC | 108,961 | 4,004,000 | 0.25% | ||
| 40 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 105,257 | 3,869,000 | 0.24% | ||
| 41 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 104,600 | 3,844,000 | 0.24% | Put | |
| 42 | Artal Group S.A. | 100,000 | 3,675,000 | 0.23% | ||
| 43 | Rhenman & Partners Asset Management AB | 100,000 | 3,675,000 | 0.23% | ||
| 44 | BALYASNY ASSET MANAGEMENT L.P. | 100,000 | 3,675,000 | 0.23% | Call | |
| 45 | Artal Group S.A. | 100,000 | 3,675,000 | 0.23% | Call | |
| 46 | ASCEND CAPITAL, LLC | 100,000 | 3,674,000 | 0.23% | ||
| 47 | MILLENNIUM MANAGEMENT LLC | 99,319 | 3,650,000 | 0.22% | ||
| 48 | NEW YORK STATE COMMON RETIREMENT FUND | 92,673 | 3,406,000 | 0.21% | ||
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 90,000 | 3,308,000 | 0.20% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,600 | 3,219,000 | 0.20% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
