| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,452,136 | 202,855,000 | 15.10% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 183,335,000 | 13.64% | ||
| 3 | BB BIOTECH AG | 4,360,399 | 137,091,000 | 10.20% | ||
| 4 | Bain Capital Public Equity Management, LLC | 3,136,374 | 98,608,000 | 7.34% | ||
| 5 | VANGUARD GROUP INC | 2,303,621 | 72,425,000 | 5.39% | ||
| 6 | Tourbillon Capital Partners, L.P. | 1,775,297 | 55,815,000 | 4.15% | ||
| 7 | STATE STREET CORP | 1,588,379 | 49,938,000 | 3.72% | ||
| 8 | BlackRock Fund Advisors | 1,367,137 | 42,983,000 | 3.20% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 1,253,695 | 39,416,000 | 2.93% | ||
| 10 | CITADEL ADVISORS LLC | 961,389 | 30,226,000 | 2.25% | ||
| 11 | Rock Springs Capital Management LP | 808,500 | 25,419,000 | 1.89% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 807,600 | 25,391,000 | 1.89% | ||
| 13 | ROYAL BANK OF CANADA | 801,424 | 25,196,000 | 1.87% | ||
| 14 | JENNISON ASSOCIATES LLC | 588,370 | 18,498,000 | 1.38% | ||
| 15 | FRANKLIN RESOURCES INC | 464,200 | 14,594,000 | 1.09% | ||
| 16 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 460,100 | 14,466,000 | 1.08% | Put | |
| 17 | ING GROEP NV | 451,486 | 14,181,000 | 1.06% | ||
| 18 | DEUTSCHE BANK AG\ | 446,211 | 14,027,000 | 1.04% | ||
| 19 | Apex Capital Management | 443,861 | 13,955,000 | 1.04% | ||
| 20 | ALLIANCEBERNSTEIN L.P. | 440,006 | 13,834,000 | 1.03% | ||
| 21 | GOLDMAN SACHS GROUP INC | 416,272 | 13,088,000 | 0.97% | ||
| 22 | Tourbillon Capital Partners, L.P. | 401,100 | 12,611,000 | 0.94% | Call | |
| 23 | NORTHERN TRUST CORP | 366,087 | 11,509,000 | 0.86% | ||
| 24 | WELLS FARGO & COMPANY/MN | 361,609 | 11,370,000 | 0.85% | ||
| 25 | OppenheimerFunds, Inc. | 357,920 | 11,253,000 | 0.84% | ||
| 26 | NORGES BANK | 353,123 | 11,102,000 | 0.83% | ||
| 27 | GOLDMAN SACHS GROUP INC | 338,000 | 10,627,000 | 0.79% | Put | |
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 327,783 | 10,305,000 | 0.77% | ||
| 29 | BANK OF AMERICA CORP /DE/ | 248,209 | 7,805,000 | 0.58% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 235,675 | 7,409,000 | 0.55% | ||
| 31 | CITIGROUP INC | 188,878 | 5,938,000 | 0.44% | ||
| 32 | CREDIT SUISSE AG/ | 163,425 | 5,139,000 | 0.38% | ||
| 33 | GROUP ONE TRADING LLC | 159,694 | 5,021,000 | 0.37% | ||
| 34 | Bank of New York Mellon Corp | 153,006 | 4,810,000 | 0.36% | ||
| 35 | JPMORGAN CHASE & CO | 147,112 | 4,626,000 | 0.34% | ||
| 36 | PointState Capital LP | 130,000 | 4,087,000 | 0.30% | ||
| 37 | NOMURA HOLDINGS INC | 129,700 | 4,066,000 | 0.30% | Call | |
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 123,118 | 3,871,000 | 0.29% | ||
| 39 | BlackRock Investment Management, LLC | 114,955 | 3,614,000 | 0.27% | ||
| 40 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 114,309 | 3,594,000 | 0.27% | ||
| 41 | JANE STREET GROUP, LLC | 113,000 | 3,553,000 | 0.26% | Put | |
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 112,717 | 3,544,000 | 0.26% | ||
| 43 | Rhenman & Partners Asset Management AB | 105,000 | 3,301,000 | 0.25% | ||
| 44 | Laurion Capital Management LP | 100,000 | 3,144,000 | 0.23% | Call | |
| 45 | J. Goldman & Co LP | 99,900 | 3,141,000 | 0.23% | ||
| 46 | SPHERA FUNDS MANAGEMENT LTD. | 90,000 | 2,830,000 | 0.21% | ||
| 47 | GUGGENHEIM CAPITAL LLC | 82,183 | 2,584,000 | 0.19% | ||
| 48 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 80,700 | 2,537,000 | 0.19% | ||
| 49 | NATIXIS | 80,000 | 2,515,000 | 0.19% | ||
| 50 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,300 | 2,462,000 | 0.18% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
