| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,438,288 | 396,213,000 | 16.56% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 358,855,000 | 15.00% | ||
| 3 | BB BIOTECH AG | 4,272,140 | 262,907,000 | 10.99% | ||
| 4 | VANGUARD GROUP INC | 2,263,647 | 139,305,000 | 5.82% | ||
| 5 | Bain Capital Public Equity Management, LLC | 2,029,317 | 124,884,000 | 5.22% | ||
| 6 | BlackRock Fund Advisors | 1,333,716 | 82,077,000 | 3.43% | ||
| 7 | STATE STREET CORP | 1,135,077 | 69,850,000 | 2.92% | ||
| 8 | Tourbillon Capital Partners, L.P. | 1,109,376 | 68,271,000 | 2.85% | ||
| 9 | FARALLON CAPITAL MANAGEMENT LLC | 1,075,695 | 66,198,000 | 2.77% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 803,808 | 49,466,000 | 2.07% | ||
| 11 | Rock Springs Capital Management LP | 597,500 | 36,770,000 | 1.54% | ||
| 12 | Tourbillon Capital Partners, L.P. | 591,000 | 36,370,000 | 1.52% | Call | |
| 13 | JENNISON ASSOCIATES LLC | 576,840 | 35,499,000 | 1.48% | ||
| 14 | ROYAL BANK OF CANADA | 533,355 | 32,823,000 | 1.37% | ||
| 15 | DEUTSCHE BANK AG\ | 531,596 | 32,713,000 | 1.37% | ||
| 16 | CITADEL ADVISORS LLC | 506,429 | 31,165,000 | 1.30% | ||
| 17 | GOLDMAN SACHS GROUP INC | 433,189 | 26,658,000 | 1.11% | ||
| 18 | WELLS FARGO & COMPANY/MN | 422,217 | 25,984,000 | 1.09% | ||
| 19 | ALLIANCEBERNSTEIN L.P. | 373,288 | 25,873,000 | 1.08% | ||
| 20 | Apex Capital Management | 413,425 | 25,442,000 | 1.06% | ||
| 21 | NORGES BANK | 385,465 | 23,721,000 | 0.99% | ||
| 22 | FRANKLIN RESOURCES INC | 360,800 | 22,204,000 | 0.93% | ||
| 23 | NORTHERN TRUST CORP | 359,351 | 22,115,000 | 0.92% | ||
| 24 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 311,191 | 19,151,000 | 0.80% | ||
| 25 | HIGHLAND CAPITAL MANAGEMENT LP | 279,268 | 17,186,000 | 0.72% | ||
| 26 | GOLDMAN SACHS GROUP INC | 250,200 | 15,397,000 | 0.64% | Put | |
| 27 | BANK OF AMERICA CORP /DE/ | 236,317 | 14,543,000 | 0.61% | ||
| 28 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 228,786 | 14,079,000 | 0.59% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 223,823 | 13,774,000 | 0.58% | ||
| 30 | Invesco Ltd. | 215,388 | 13,255,000 | 0.55% | ||
| 31 | SKANDINAVISKA ENSKILDA BANKEN AB (PUBL) | 210,000 | 13,115,000 | 0.55% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 191,500 | 11,785,000 | 0.49% | Put | |
| 33 | ING GROEP NV | 174,175 | 10,717,000 | 0.45% | ||
| 34 | Bank of New York Mellon Corp | 167,522 | 10,310,000 | 0.43% | ||
| 35 | CITIGROUP INC | 165,782 | 10,202,000 | 0.43% | ||
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 157,100 | 9,668,000 | 0.40% | Call | |
| 37 | APEX CAPITAL, LLC | 150,000 | 9,231,000 | 0.39% | ||
| 38 | Tyrus Capital S.A.M. | 135,000 | 8,308,000 | 0.35% | ||
| 39 | MILLENNIUM MANAGEMENT LLC | 133,613 | 8,223,000 | 0.34% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 124,761 | 7,678,000 | 0.32% | ||
| 41 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 121,800 | 7,496,000 | 0.31% | ||
| 42 | PointState Capital LP | 120,000 | 7,385,000 | 0.31% | ||
| 43 | BlackRock Investment Management, LLC | 110,820 | 6,820,000 | 0.28% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 110,476 | 6,799,000 | 0.28% | ||
| 45 | CREDIT SUISSE AG/ | 104,406 | 6,425,000 | 0.27% | ||
| 46 | GOLDMAN SACHS GROUP INC | 100,200 | 6,166,000 | 0.26% | Call | |
| 47 | Tourbillon Capital Partners, L.P. | 100,000 | 6,154,000 | 0.26% | Put | |
| 48 | GUGGENHEIM CAPITAL LLC | 94,057 | 5,788,000 | 0.24% | ||
| 49 | Candriam S.C.A. | 90,000 | 5,539,000 | 0.23% | ||
| 50 | JPMORGAN CHASE & CO | 81,853 | 5,038,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
