| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 240,014,000 | 20.97% | ||
| 2 | FMR LLC | 5,531,448 | 227,674,000 | 19.89% | ||
| 3 | BB BIOTECH AG | 3,722,140 | 153,203,000 | 13.39% | ||
| 4 | Bain Capital Public Equity Management, LLC | 2,282,497 | 93,948,000 | 8.21% | ||
| 5 | Point72 Asset Management, L.P. | 1,203,300 | 49,528,000 | 4.33% | ||
| 6 | VANGUARD GROUP INC | 743,789 | 30,615,000 | 2.67% | ||
| 7 | FARALLON CAPITAL MANAGEMENT LLC | 731,600 | 30,113,000 | 2.63% | ||
| 8 | PFM Health Sciences, LP | 728,980 | 30,005,000 | 2.62% | ||
| 9 | BlackRock Fund Advisors | 709,581 | 29,206,000 | 2.55% | ||
| 10 | CITADEL ADVISORS LLC | 612,344 | 25,205,000 | 2.20% | ||
| 11 | STATE STREET CORP | 581,112 | 23,917,000 | 2.09% | ||
| 12 | ROYAL BANK OF CANADA | 517,800 | 21,313,000 | 1.86% | ||
| 13 | FRANKLIN RESOURCES INC | 416,200 | 17,131,000 | 1.50% | ||
| 14 | Rock Springs Capital Management LP | 400,000 | 16,464,000 | 1.44% | ||
| 15 | EverPoint Asset Management, LLC | 380,000 | 15,641,000 | 1.37% | ||
| 16 | Tourbillon Capital Partners, L.P. | 325,000 | 13,377,000 | 1.17% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 317,019 | 13,049,000 | 1.14% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 276,848 | 11,395,000 | 1.00% | ||
| 19 | JPMORGAN CHASE & CO | 154,150 | 6,345,000 | 0.55% | ||
| 20 | Candriam S.C.A. | 146,000 | 6,011,000 | 0.53% | ||
| 21 | RENAISSANCE TECHNOLOGIES LLC | 133,000 | 5,474,000 | 0.48% | ||
| 22 | MORGAN STANLEY | 111,480 | 4,589,000 | 0.40% | ||
| 23 | UBS Group AG | 101,540 | 4,180,000 | 0.37% | ||
| 24 | NORTHERN TRUST CORP | 97,900 | 4,030,000 | 0.35% | ||
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 90,467 | 3,723,000 | 0.33% | ||
| 26 | DEUTSCHE BANK AG\ | 89,081 | 3,665,000 | 0.32% | ||
| 27 | Numeric Investors LLC | 86,228 | 3,549,000 | 0.31% | ||
| 28 | GILDER GAGNON HOWE & CO LLC | 79,160 | 3,258,000 | 0.28% | ||
| 29 | Ghost Tree Capital, LLC | 75,000 | 3,087,000 | 0.27% | ||
| 30 | PERCEPTIVE ADVISORS LLC | 74,000 | 3,046,000 | 0.27% | ||
| 31 | Nicholas Investment Partners, LP | 67,097 | 2,762,000 | 0.24% | ||
| 32 | Trexquant Investment LP | 65,200 | 2,683,000 | 0.23% | ||
| 33 | A.R.T. Advisors, LLC | 63,613 | 2,618,000 | 0.23% | ||
| 34 | J. Goldman & Co LP | 60,500 | 2,490,000 | 0.22% | ||
| 35 | Bank of New York Mellon Corp | 60,450 | 2,488,000 | 0.22% | ||
| 36 | MARSHALL WACE, LLP | 52,233 | 2,150,000 | 0.19% | ||
| 37 | NORGES BANK | 44,572 | 1,835,000 | 0.16% | ||
| 38 | D. E. Shaw & Co., Inc. | 44,166 | 1,818,000 | 0.16% | ||
| 39 | Atika Capital Management LLC | 40,500 | 1,667,000 | 0.15% | ||
| 40 | HBK INVESTMENTS L P | 38,500 | 1,585,000 | 0.14% | ||
| 41 | Convergence Investment Partners, LLC | 37,700 | 1,552,000 | 0.14% | ||
| 42 | GUGGENHEIM CAPITAL LLC | 37,246 | 1,533,000 | 0.13% | ||
| 43 | CREDIT SUISSE AG/ | 36,433 | 1,500,000 | 0.13% | ||
| 44 | ProShare Advisors LLC | 31,455 | 1,295,000 | 0.11% | ||
| 45 | Spark Investment Management LLC | 28,500 | 1,172,000 | 0.10% | ||
| 46 | Bank Pictet & Cie (Europe) AG | 28,000 | 1,152,000 | 0.10% | ||
| 47 | GOLDMAN SACHS GROUP INC | 26,846 | 1,105,000 | 0.10% | ||
| 48 | BlackRock Investment Management, LLC | 25,972 | 1,069,000 | 0.09% | ||
| 49 | TIAA CREF INVESTMENT MANAGEMENT LLC | 23,966 | 986,000 | 0.09% | ||
| 50 | GAM Holding AG | 23,175 | 954,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
