| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 394,776,000 | 19.31% | ||
| 2 | FMR LLC | 5,579,076 | 377,703,000 | 18.47% | ||
| 3 | BB BIOTECH AG | 3,922,140 | 265,529,000 | 12.99% | ||
| 4 | Bain Capital Public Equity Management, LLC | 2,282,497 | 154,525,000 | 7.56% | ||
| 5 | VANGUARD GROUP INC | 1,287,130 | 87,139,000 | 4.26% | ||
| 6 | BlackRock Fund Advisors | 1,184,150 | 80,167,000 | 3.92% | ||
| 7 | STATE STREET CORP | 954,266 | 64,603,000 | 3.16% | ||
| 8 | FARALLON CAPITAL MANAGEMENT LLC | 816,095 | 55,250,000 | 2.70% | ||
| 9 | PFM Health Sciences, LP | 763,296 | 51,675,000 | 2.53% | ||
| 10 | CITADEL ADVISORS LLC | 686,953 | 46,506,000 | 2.27% | ||
| 11 | PointState Capital LP | 600,000 | 40,620,000 | 1.99% | ||
| 12 | Tourbillon Capital Partners, L.P. | 550,000 | 37,235,000 | 1.82% | ||
| 13 | ROYAL BANK OF CANADA | 517,800 | 35,055,000 | 1.71% | ||
| 14 | Rock Springs Capital Management LP | 429,000 | 29,043,000 | 1.42% | ||
| 15 | BlackRock Institutional Trust Company, N.A. | 426,259 | 28,858,000 | 1.41% | ||
| 16 | FRANKLIN RESOURCES INC | 416,200 | 28,177,000 | 1.38% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 346,040 | 23,427,000 | 1.15% | ||
| 18 | PERCEPTIVE ADVISORS LLC | 235,530 | 15,945,000 | 0.78% | ||
| 19 | WELLS FARGO & COMPANY/MN | 198,477 | 13,437,000 | 0.66% | ||
| 20 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 144,300 | 9,769,000 | 0.48% | Put | |
| 21 | Bank of New York Mellon Corp | 132,664 | 8,982,000 | 0.44% | ||
| 22 | Candriam S.C.A. | 130,000 | 8,801,000 | 0.43% | ||
| 23 | GUGGENHEIM CAPITAL LLC | 126,650 | 8,574,000 | 0.42% | ||
| 24 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 122,600 | 8,300,000 | 0.41% | Call | |
| 25 | GEODE CAPITAL MANAGEMENT, LLC | 118,730 | 8,038,000 | 0.39% | ||
| 26 | NORTHERN TRUST CORP | 116,922 | 7,915,000 | 0.39% | ||
| 27 | RENAISSANCE TECHNOLOGIES LLC | 111,200 | 7,528,000 | 0.37% | ||
| 28 | JPMORGAN CHASE & CO | 108,651 | 7,356,000 | 0.36% | ||
| 29 | HIGHLAND CAPITAL MANAGEMENT LP | 103,411 | 7,001,000 | 0.34% | ||
| 30 | BlackRock Investment Management, LLC | 98,949 | 6,699,000 | 0.33% | ||
| 31 | TIAA CREF INVESTMENT MANAGEMENT LLC | 98,568 | 6,673,000 | 0.33% | ||
| 32 | CREDIT SUISSE AG/ | 95,843 | 6,489,000 | 0.32% | ||
| 33 | UBS Group AG | 76,350 | 5,169,000 | 0.25% | ||
| 34 | GILDER GAGNON HOWE & CO LLC | 74,622 | 5,052,000 | 0.25% | ||
| 35 | Atika Capital Management LLC | 64,000 | 4,333,000 | 0.21% | ||
| 36 | NORGES BANK | 60,745 | 4,112,000 | 0.20% | ||
| 37 | Nicholas Investment Partners, LP | 58,314 | 3,948,000 | 0.19% | ||
| 38 | MORGAN STANLEY | 57,336 | 3,881,000 | 0.19% | ||
| 39 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 53,432 | 3,617,000 | 0.18% | ||
| 40 | BANK OF AMERICA CORP /DE/ | 52,564 | 3,559,000 | 0.17% | ||
| 41 | HBK INVESTMENTS L P | 50,238 | 3,401,000 | 0.17% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 49,400 | 3,344,000 | 0.16% | ||
| 43 | Jefferies Group LLC | 45,000 | 3,047,000 | 0.15% | Put | |
| 44 | VOLORIDGE INVESTMENT MANAGEMENT, LLC | 43,501 | 2,945,000 | 0.14% | ||
| 45 | TEACHERS ADVISORS, LLC | 42,556 | 2,881,000 | 0.14% | ||
| 46 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 42,314 | 2,865,000 | 0.14% | ||
| 47 | ALPS ADVISORS INC | 37,613 | 2,546,000 | 0.12% | ||
| 48 | BLACKROCK ADVISORS LLC | 35,626 | 2,412,000 | 0.12% | ||
| 49 | ProShare Advisors LLC | 33,966 | 2,299,000 | 0.11% | ||
| 50 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 33,410 | 2,262,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
