| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,462,411 | 349,552,000 | 14.75% | ||
| 2 | BB BIOTECH AG | 4,360,399 | 235,854,000 | 9.96% | ||
| 3 | MPM ASSET MANAGEMENT LLC | 3,887,502 | 210,275,000 | 8.88% | ||
| 4 | VANGUARD GROUP INC | 2,698,134 | 145,942,000 | 6.16% | ||
| 5 | Bain Capital Public Equity Management, LLC | 2,383,198 | 128,907,000 | 5.44% | ||
| 6 | Tourbillon Capital Partners, L.P. | 2,044,936 | 110,611,000 | 4.67% | ||
| 7 | FARALLON CAPITAL MANAGEMENT LLC | 1,570,100 | 84,927,000 | 3.58% | ||
| 8 | BlackRock Fund Advisors | 1,429,056 | 77,298,000 | 3.26% | ||
| 9 | STATE STREET CORP | 1,186,138 | 64,157,000 | 2.71% | ||
| 10 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,052,018 | 56,904,000 | 2.40% | ||
| 11 | JENNISON ASSOCIATES LLC | 971,926 | 52,571,000 | 2.22% | ||
| 12 | Rock Springs Capital Management LP | 892,000 | 48,248,000 | 2.04% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 827,990 | 44,786,000 | 1.89% | ||
| 14 | FRANKLIN RESOURCES INC | 654,500 | 35,402,000 | 1.49% | ||
| 15 | Tourbillon Capital Partners, L.P. | 610,300 | 33,011,000 | 1.39% | Call | |
| 16 | ARROWGRASS CAPITAL PARTNERS (US) LP | 597,930 | 32,342,000 | 1.37% | ||
| 17 | DEUTSCHE BANK AG\ | 576,849 | 31,199,000 | 1.32% | ||
| 18 | Fiera Capital Corp | 560,925 | 30,341,000 | 1.28% | ||
| 19 | PointState Capital LP | 482,500 | 26,098,000 | 1.10% | ||
| 20 | GOLDMAN SACHS GROUP INC | 432,716 | 23,406,000 | 0.99% | ||
| 21 | PICTET ASSET MANAGEMENT LTD | 400,718 | 21,675,000 | 0.91% | ||
| 22 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 385,100 | 20,830,000 | 0.88% | Put | |
| 23 | Point72 Asset Management, L.P. | 381,100 | 20,614,000 | 0.87% | ||
| 24 | EverPoint Asset Management, LLC | 370,000 | 20,013,000 | 0.84% | ||
| 25 | NORTHERN TRUST CORP | 363,511 | 19,662,000 | 0.83% | ||
| 26 | ALLIANCEBERNSTEIN L.P. | 347,353 | 18,788,000 | 0.79% | ||
| 27 | NORGES BANK | 355,474 | 18,364,000 | 0.78% | ||
| 28 | ROYAL BANK OF CANADA | 328,138 | 17,749,000 | 0.75% | ||
| 29 | CITADEL ADVISORS LLC | 316,984 | 17,146,000 | 0.72% | ||
| 30 | PERCEPTIVE ADVISORS LLC | 313,502 | 16,957,000 | 0.72% | ||
| 31 | OppenheimerFunds, Inc. | 300,800 | 16,270,000 | 0.69% | ||
| 32 | WELLS FARGO & COMPANY/MN | 280,643 | 15,180,000 | 0.64% | ||
| 33 | Bank of New York Mellon Corp | 276,856 | 14,974,000 | 0.63% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 272,400 | 14,734,000 | 0.62% | Call | |
| 35 | Tourbillon Capital Partners, L.P. | 264,000 | 14,280,000 | 0.60% | Put | |
| 36 | JPMORGAN CHASE & CO | 263,040 | 14,228,000 | 0.60% | ||
| 37 | GEODE CAPITAL MANAGEMENT, LLC | 253,869 | 13,731,000 | 0.58% | ||
| 38 | BANK OF AMERICA CORP /DE/ | 220,719 | 11,940,000 | 0.50% | ||
| 39 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 179,551 | 9,712,000 | 0.41% | ||
| 40 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 171,486 | 9,276,000 | 0.39% | ||
| 41 | Jefferies Group LLC | 161,800 | 8,752,000 | 0.37% | Call | |
| 42 | GROUP ONE TRADING LLC | 142,216 | 7,692,000 | 0.32% | ||
| 43 | CREDIT SUISSE AG/ | 137,002 | 7,410,000 | 0.31% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,611 | 7,389,000 | 0.31% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 132,579 | 7,172,000 | 0.30% | ||
| 46 | BlackRock Investment Management, LLC | 118,269 | 6,397,000 | 0.27% | ||
| 47 | TIAA CREF INVESTMENT MANAGEMENT LLC | 106,832 | 5,779,000 | 0.24% | ||
| 48 | Nicholas Investment Partners, LP | 102,759 | 5,558,000 | 0.23% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 100,757 | 5,450,000 | 0.23% | ||
| 50 | JANA PARTNERS LLC | 92,394 | 4,998,000 | 0.21% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
