| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,366,543 | 441,266,000 | 17.24% | ||
| 2 | MPM ASSET MANAGEMENT LLC | 5,831,253 | 404,164,000 | 15.79% | ||
| 3 | BB BIOTECH AG | 4,272,140 | 296,102,000 | 11.57% | ||
| 4 | Bain Capital Public Equity Management, LLC | 2,018,971 | 139,935,000 | 5.47% | ||
| 5 | VANGUARD GROUP INC | 1,864,015 | 129,195,000 | 5.05% | ||
| 6 | BlackRock Fund Advisors | 1,414,089 | 98,011,000 | 3.83% | ||
| 7 | FARALLON CAPITAL MANAGEMENT LLC | 1,045,695 | 72,477,000 | 2.83% | ||
| 8 | Tourbillon Capital Partners, L.P. | 1,004,377 | 69,613,000 | 2.72% | ||
| 9 | STATE STREET CORP | 923,660 | 64,022,000 | 2.50% | ||
| 10 | MILLENNIUM MANAGEMENT LLC | 920,863 | 63,825,000 | 2.49% | ||
| 11 | CITADEL ADVISORS LLC | 914,042 | 63,352,000 | 2.47% | ||
| 12 | BlackRock Institutional Trust Company, N.A. | 771,183 | 53,451,000 | 2.09% | ||
| 13 | ALPS ADVISORS INC | 66,971 | 46,418,000 | 1.81% | ||
| 14 | JENNISON ASSOCIATES LLC | 577,715 | 40,041,000 | 1.56% | ||
| 15 | PFM Health Sciences, LP | 577,034 | 39,994,000 | 1.56% | ||
| 16 | Rock Springs Capital Management LP | 560,000 | 38,814,000 | 1.52% | ||
| 17 | WELLS FARGO & COMPANY/MN | 392,616 | 27,212,000 | 1.06% | ||
| 18 | ROYAL BANK OF CANADA | 389,438 | 26,992,000 | 1.05% | ||
| 19 | NORGES BANK | 385,465 | 26,716,000 | 1.04% | ||
| 20 | FRANKLIN RESOURCES INC | 360,800 | 25,007,000 | 0.98% | ||
| 21 | NORTHERN TRUST CORP | 352,461 | 24,429,000 | 0.95% | ||
| 22 | COMMERZBANK AKTIENGESELLSCHAFT /FI | 300,939 | 20,858,000 | 0.81% | ||
| 23 | GEODE CAPITAL MANAGEMENT, LLC | 222,259 | 15,404,000 | 0.60% | ||
| 24 | GOLDMAN SACHS GROUP INC | 213,067 | 14,768,000 | 0.58% | ||
| 25 | Invesco Ltd. | 195,399 | 13,543,000 | 0.53% | ||
| 26 | CITIGROUP INC | 176,544 | 12,237,000 | 0.48% | ||
| 27 | PointState Capital LP | 175,000 | 12,129,000 | 0.47% | ||
| 28 | TWO SIGMA INVESTMENTS, LP | 164,886 | 11,428,000 | 0.45% | ||
| 29 | Bank of New York Mellon Corp | 155,898 | 10,805,000 | 0.42% | ||
| 30 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 153,623 | 10,648,000 | 0.42% | ||
| 31 | DEUTSCHE BANK AG\ | 153,625 | 10,645,000 | 0.42% | ||
| 32 | BALYASNY ASSET MANAGEMENT L.P. | 148,180 | 10,270,000 | 0.40% | ||
| 33 | ING GROEP NV | 144,295 | 10,013,000 | 0.39% | ||
| 34 | TWO SIGMA ADVISERS, LP | 138,900 | 9,516,000 | 0.37% | ||
| 35 | CREDIT SUISSE AG/ | 133,818 | 9,275,000 | 0.36% | ||
| 36 | HIGHLAND CAPITAL MANAGEMENT LP | 125,000 | 8,664,000 | 0.34% | ||
| 37 | GUGGENHEIM CAPITAL LLC | 117,690 | 8,157,000 | 0.32% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 116,599 | 8,081,000 | 0.32% | ||
| 39 | BlackRock Investment Management, LLC | 110,222 | 7,639,000 | 0.30% | ||
| 40 | Candriam S.C.A. | 104,400 | 7,236,000 | 0.28% | ||
| 41 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 97,311 | 6,745,000 | 0.26% | ||
| 42 | Tourbillon Capital Partners, L.P. | 88,800 | 6,155,000 | 0.24% | Call | |
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,600 | 6,002,000 | 0.23% | Put | |
| 44 | JPMORGAN CHASE & CO | 78,221 | 5,421,000 | 0.21% | ||
| 45 | UBS Group AG | 74,655 | 5,175,000 | 0.20% | ||
| 46 | CQS Cayman LP | 70,000 | 4,852,000 | 0.19% | ||
| 47 | Apex Capital Management | 69,709 | 4,832,000 | 0.19% | ||
| 48 | Nicholas Investment Partners, LP | 62,187 | 4,310,000 | 0.17% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,232 | 4,175,000 | 0.16% | ||
| 50 | BLACKROCK ADVISORS LLC | 59,823 | 4,146,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
