| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 6,466,756 | 245,931,000 | 14.36% | ||
| 2 | BB BIOTECH AG | 4,360,399 | 165,826,000 | 9.68% | ||
| 3 | MPM ASSET MANAGEMENT LLC | 3,887,502 | 147,842,000 | 8.63% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 3,079,831 | 117,126,000 | 6.84% | ||
| 5 | VANGUARD GROUP INC | 2,917,458 | 110,951,000 | 6.48% | ||
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 2,130,000 | 81,004,000 | 4.73% | ||
| 7 | STATE STREET CORP | 1,885,161 | 71,694,000 | 4.19% | ||
| 8 | Tourbillon Capital Partners, L.P. | 1,725,028 | 65,603,000 | 3.83% | ||
| 9 | Bain Capital Public Equity Management, LLC | 1,643,001 | 62,483,000 | 3.65% | ||
| 10 | BlackRock Fund Advisors | 1,571,666 | 59,770,000 | 3.49% | ||
| 11 | Rock Springs Capital Management LP | 910,250 | 34,617,000 | 2.02% | ||
| 12 | JENNISON ASSOCIATES LLC | 886,038 | 33,696,000 | 1.97% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 868,144 | 33,016,000 | 1.93% | ||
| 14 | Tourbillon Capital Partners, L.P. | 852,300 | 32,413,000 | 1.89% | Call | |
| 15 | FRANKLIN RESOURCES INC | 609,703 | 23,187,000 | 1.35% | ||
| 16 | PICTET ASSET MANAGEMENT LTD | 476,390 | 18,117,000 | 1.06% | ||
| 17 | Fiera Capital Corp | 468,310 | 17,810,000 | 1.04% | ||
| 18 | ALLIANCEBERNSTEIN L.P. | 406,762 | 15,469,000 | 0.90% | ||
| 19 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 389,100 | 14,797,000 | 0.86% | Put | |
| 20 | NORTHERN TRUST CORP | 383,080 | 14,568,000 | 0.85% | ||
| 21 | ROYAL BANK OF CANADA | 356,663 | 13,565,000 | 0.79% | ||
| 22 | NORGES BANK | 355,474 | 13,519,000 | 0.79% | ||
| 23 | DEUTSCHE BANK AG\ | 327,771 | 12,461,000 | 0.73% | ||
| 24 | OppenheimerFunds, Inc. | 300,800 | 11,439,000 | 0.67% | ||
| 25 | PointState Capital LP | 300,000 | 11,409,000 | 0.67% | ||
| 26 | GEODE CAPITAL MANAGEMENT, LLC | 280,178 | 10,655,000 | 0.62% | ||
| 27 | GROUP ONE TRADING LLC | 277,703 | 10,561,000 | 0.62% | ||
| 28 | Bank of New York Mellon Corp | 264,578 | 10,062,000 | 0.59% | ||
| 29 | PERCEPTIVE ADVISORS LLC | 263,872 | 10,035,000 | 0.59% | ||
| 30 | JPMORGAN CHASE & CO | 255,651 | 9,722,000 | 0.57% | ||
| 31 | WELLS FARGO & COMPANY/MN | 254,484 | 9,679,000 | 0.57% | ||
| 32 | VOYA INVESTMENT MANAGEMENT LLC | 231,810 | 8,816,000 | 0.51% | ||
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 216,300 | 8,226,000 | 0.48% | Call | |
| 34 | PEREGRINE CAPITAL MANAGEMENT INC /MN/ | 211,761 | 8,053,000 | 0.47% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 205,734 | 7,824,000 | 0.46% | ||
| 36 | BANK OF AMERICA CORP /DE/ | 197,103 | 7,496,000 | 0.44% | ||
| 37 | GOLDMAN SACHS GROUP INC | 193,046 | 7,342,000 | 0.43% | ||
| 38 | OXFORD ASSET MANAGEMENT LLP | 190,540 | 7,246,000 | 0.42% | ||
| 39 | CITIGROUP INC | 185,031 | 7,037,000 | 0.41% | ||
| 40 | JANA PARTNERS LLC | 172,310 | 6,553,000 | 0.38% | ||
| 41 | MARSHALL WACE, LLP | 156,432 | 5,949,000 | 0.35% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 147,635 | 5,615,000 | 0.33% | ||
| 43 | CLEARBRIDGE, LLC | 141,860 | 5,395,000 | 0.32% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 140,395 | 5,340,000 | 0.31% | ||
| 45 | MORGAN STANLEY | 137,516 | 5,230,000 | 0.31% | ||
| 46 | CITADEL ADVISORS LLC | 135,843 | 5,166,000 | 0.30% | ||
| 47 | BlackRock Investment Management, LLC | 117,683 | 4,475,000 | 0.26% | ||
| 48 | Jefferies Group LLC | 111,800 | 4,252,000 | 0.25% | Call | |
| 49 | NOMURA HOLDINGS INC | 100,600 | 3,857,000 | 0.23% | Call | |
| 50 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 100,000 | 3,803,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
