| 1 |
Third Rock Ventures, LLC |
5,602,045 |
110,080,000 |
38.01% |
|
|
| 2 |
FMR LLC |
3,271,002 |
64,276,000 |
22.20% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
765,246 |
15,037,000 |
5.19% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
732,960 |
14,403,000 |
4.97% |
|
|
| 5 |
Bain Capital Public Equity Management, LLC |
666,480 |
13,096,000 |
4.52% |
|
|
| 6 |
VHCP Management, LLC |
541,480 |
10,024,000 |
3.46% |
|
|
| 7 |
WELLINGTON MANAGEMENT GROUP LLP |
478,330 |
9,399,000 |
3.25% |
|
|
| 8 |
JENNISON ASSOCIATES LLC |
404,157 |
7,942,000 |
2.74% |
|
|
| 9 |
SABBY MANAGEMENT, LLC |
327,566 |
6,437,000 |
2.22% |
|
|
| 10 |
PERCEPTIVE ADVISORS LLC |
275,000 |
5,404,000 |
1.87% |
|
|
| 11 |
BlackRock Fund Advisors |
169,910 |
3,339,000 |
1.15% |
|
|
| 12 |
Alyeska Investment Group, L.P. |
126,953 |
2,495,000 |
0.86% |
|
|
| 13 |
Capital World Investors |
125,000 |
2,456,000 |
0.85% |
|
|
| 14 |
JPMORGAN CHASE & CO |
123,275 |
2,422,000 |
0.84% |
|
|
| 15 |
VANGUARD GROUP INC |
122,817 |
2,413,000 |
0.83% |
|
|
| 16 |
Lombard Odier Asset Management (USA) Corp |
104,929 |
2,062,000 |
0.71% |
|
|
| 17 |
SPHERA FUNDS MANAGEMENT LTD. |
97,100 |
1,908,000 |
0.66% |
|
|
| 18 |
MARSHALL WACE, LLP |
84,741 |
1,665,000 |
0.57% |
|
|
| 19 |
Ghost Tree Capital, LLC |
75,000 |
1,474,000 |
0.51% |
|
|
| 20 |
GOLDMAN SACHS GROUP INC |
65,440 |
1,286,000 |
0.44% |
|
|
| 21 |
MORGAN STANLEY |
62,659 |
1,231,000 |
0.43% |
|
|
| 22 |
FARALLON CAPITAL MANAGEMENT LLC |
60,000 |
1,179,000 |
0.41% |
|
|
| 23 |
BlackRock Institutional Trust Company, N.A. |
55,251 |
1,086,000 |
0.38% |
|
|
| 24 |
Lisanti Capital Growth, LLC |
50,830 |
999,000 |
0.34% |
|
|
| 25 |
STATE STREET CORP |
50,300 |
990,000 |
0.34% |
|
|
| 26 |
Weiss Multi-Strategy Advisers LLC |
45,000 |
884,000 |
0.31% |
|
|
| 27 |
DEUTSCHE BANK AG\ |
43,071 |
845,000 |
0.29% |
|
|
| 28 |
EMERALD MUTUAL FUND ADVISERS TRUST |
35,000 |
688,000 |
0.24% |
|
|
| 29 |
COMMONWEALTH BANK OF AUSTRALIA |
24,300 |
477,000 |
0.16% |
|
|
| 30 |
NORTHERN TRUST CORP |
20,681 |
407,000 |
0.14% |
|
|
| 31 |
BlackRock Investment Management, LLC |
18,972 |
373,000 |
0.13% |
|
|
| 32 |
Spark Investment Management LLC |
17,200 |
335,000 |
0.12% |
|
|
| 33 |
GREAT POINT PARTNERS LLC |
16,855 |
331,000 |
0.11% |
|
|
| 34 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
16,485 |
324,000 |
0.11% |
|
|
| 35 |
Bank of New York Mellon Corp |
16,315 |
320,000 |
0.11% |
|
|
| 36 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
14,957 |
294,000 |
0.10% |
|
|
| 37 |
GEODE CAPITAL MANAGEMENT, LLC |
13,153 |
258,000 |
0.09% |
|
|
| 38 |
MILLENNIUM MANAGEMENT LLC |
12,968 |
255,000 |
0.09% |
|
|
| 39 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,700 |
250,000 |
0.09% |
|
|
| 40 |
Nationwide Fund Advisors |
9,194 |
181,000 |
0.06% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
6,431 |
126,000 |
0.04% |
|
|
| 42 |
BLACKROCK ADVISORS LLC |
2,652 |
52,000 |
0.02% |
|
|
| 43 |
STRS OHIO |
2,400 |
47,000 |
0.02% |
|
|
| 44 |
Pinnacle Summer Investments, Inc. |
800 |
16,000 |
0.01% |
|
|
| 45 |
CITIGROUP INC |
244 |
5,000 |
0.00% |
|
|
