| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,920,252 | 135,758,000 | 18.36% | ||
| 2 | Third Rock Ventures, LLC | 3,202,045 | 110,887,000 | 15.00% | ||
| 3 | JENNISON ASSOCIATES LLC | 1,239,067 | 42,909,000 | 5.80% | ||
| 4 | JANUS HENDERSON INVESTORS US LLC | 1,087,670 | 37,666,000 | 5.09% | ||
| 5 | FRANKLIN RESOURCES INC | 1,043,684 | 36,142,000 | 4.89% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,007,614 | 34,894,000 | 4.72% | ||
| 7 | Foresite Capital Management II, LLC | 811,300 | 28,095,000 | 3.80% | ||
| 8 | BlackRock Fund Advisors | 781,147 | 27,051,000 | 3.66% | ||
| 9 | Bain Capital Public Equity Management, LLC | 666,480 | 23,080,000 | 3.12% | ||
| 10 | Capital World Investors | 660,000 | 22,856,000 | 3.09% | ||
| 11 | WELLINGTON MANAGEMENT GROUP LLP | 589,240 | 20,405,000 | 2.76% | ||
| 12 | VHCP Management, LLC | 541,480 | 18,751,000 | 2.54% | ||
| 13 | VANGUARD GROUP INC | 523,804 | 18,140,000 | 2.45% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 511,599 | 17,717,000 | 2.40% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 459,590 | 15,916,000 | 2.15% | ||
| 16 | LOOMIS SAYLES & CO L P | 412,280 | 14,277,000 | 1.93% | ||
| 17 | Granahan Investment Management, LLC | 326,207 | 11,297,000 | 1.53% | ||
| 18 | BAKER BROS. ADVISORS LP | 287,677 | 9,962,000 | 1.35% | ||
| 19 | FARALLON CAPITAL MANAGEMENT LLC | 230,000 | 7,965,000 | 1.08% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 223,880 | 7,753,000 | 1.05% | ||
| 21 | BLACKROCK ADVISORS LLC | 203,395 | 7,044,000 | 0.95% | ||
| 22 | LORD, ABBETT & CO. LLC | 173,699 | 6,015,000 | 0.81% | ||
| 23 | GOLDMAN SACHS GROUP INC | 140,589 | 4,869,000 | 0.66% | ||
| 24 | Asset Management One Co., Ltd. | 134,341 | 4,550,000 | 0.62% | ||
| 25 | AlpInvest Partners B.V. | 128,766 | 4,459,000 | 0.60% | ||
| 26 | TFS CAPITAL LLC | 124,622 | 4,316,000 | 0.58% | ||
| 27 | JPMORGAN CHASE & CO | 115,390 | 3,996,000 | 0.54% | ||
| 28 | NORTHERN TRUST CORP | 109,179 | 3,781,000 | 0.51% | ||
| 29 | Lombard Odier Asset Management (USA) Corp | 102,641 | 3,554,000 | 0.48% | ||
| 30 | Candriam S.C.A. | 100,000 | 3,463,000 | 0.47% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 91,091 | 3,154,000 | 0.43% | ||
| 32 | Bank of New York Mellon Corp | 82,934 | 2,872,000 | 0.39% | ||
| 33 | OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 80,200 | 2,777,000 | 0.38% | ||
| 34 | HARBOURVEST PARTNERS LLC | 77,434 | 2,682,000 | 0.36% | ||
| 35 | COLUMBUS CIRCLE INVESTORS | 73,705 | 2,552,000 | 0.35% | ||
| 36 | BlackRock Investment Management, LLC | 71,104 | 2,462,000 | 0.33% | ||
| 37 | MACQUARIE GROUP LTD | 70,000 | 2,424,000 | 0.33% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 64,268 | 2,226,000 | 0.30% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 62,134 | 2,152,000 | 0.29% | ||
| 40 | EMERALD MUTUAL FUND ADVISERS TRUST | 55,000 | 1,905,000 | 0.26% | ||
| 41 | HAMILTON LANE ADVISORS LLC | 54,774 | 1,897,000 | 0.26% | ||
| 42 | ACUTA CAPITAL PARTNERS, LLC | 52,900 | 1,832,000 | 0.25% | ||
| 43 | CREDIT SUISSE AG/ | 49,261 | 1,705,000 | 0.23% | ||
| 44 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 34,873 | 1,208,000 | 0.16% | ||
| 45 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,700 | 1,132,000 | 0.15% | Call | |
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 30,110 | 1,043,000 | 0.14% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 29,685 | 1,028,000 | 0.14% | ||
| 48 | Nationwide Fund Advisors | 29,374 | 1,017,000 | 0.14% | ||
| 49 | ALPS ADVISORS INC | 26,670 | 924,000 | 0.12% | ||
| 50 | DEUTSCHE BANK AG\ | 26,252 | 907,000 | 0.12% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
