| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,069,020 | 13,468,000 | 29.18% | ||
| 2 | BlackRock Fund Advisors | 1,005,269 | 3,327,000 | 7.21% | ||
| 3 | VANGUARD GROUP INC | 953,506 | 3,156,000 | 6.84% | ||
| 4 | Foresite Capital Management II, LLC | 760,046 | 2,516,000 | 5.45% | ||
| 5 | VHCP Management, LLC | 602,114 | 1,993,000 | 4.32% | ||
| 6 | FORESITE CAPITAL MANAGEMENT III, LLC | 537,495 | 1,779,000 | 3.85% | ||
| 7 | ROYCE & ASSOCIATES LP | 504,075 | 1,668,000 | 3.61% | ||
| 8 | BlackRock Institutional Trust Company, N.A. | 503,109 | 1,665,000 | 3.61% | ||
| 9 | BALYASNY ASSET MANAGEMENT L.P. | 480,020 | 1,589,000 | 3.44% | ||
| 10 | NORTHERN TRUST CORP | 375,717 | 1,243,000 | 2.69% | ||
| 11 | D. E. Shaw & Co., Inc. | 374,285 | 1,239,000 | 2.68% | ||
| 12 | Spark Investment Management LLC | 347,500 | 1,150,000 | 2.49% | ||
| 13 | STATE STREET CORP | 338,610 | 1,122,000 | 2.43% | ||
| 14 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 276,300 | 915,000 | 1.98% | ||
| 15 | PANAGORA ASSET MANAGEMENT INC | 238,303 | 789,000 | 1.71% | ||
| 16 | DIMENSIONAL FUND ADVISORS LP | 216,657 | 717,000 | 1.55% | ||
| 17 | VHCP MANAGEMENT II, LLC | 141,479 | 468,000 | 1.01% | ||
| 18 | TIAA CREF INVESTMENT MANAGEMENT LLC | 141,520 | 468,000 | 1.01% | ||
| 19 | GEODE CAPITAL MANAGEMENT, LLC | 139,491 | 461,000 | 1.00% | ||
| 20 | FT OPTIONS LLC | 131,930 | 437,000 | 0.95% | ||
| 21 | AQR CAPITAL MANAGEMENT LLC | 130,495 | 432,000 | 0.94% | ||
| 22 | Candriam S.C.A. | 108,000 | 357,000 | 0.77% | ||
| 23 | FEDERATED HERMES, INC. | 102,128 | 338,000 | 0.73% | ||
| 24 | Connor, Clark & Lunn Investment Management Ltd. | 101,325 | 335,000 | 0.73% | ||
| 25 | MILLENNIUM MANAGEMENT LLC | 98,200 | 325,000 | 0.70% | ||
| 26 | BlackRock Investment Management, LLC | 89,134 | 295,000 | 0.64% | ||
| 27 | PRICE T ROWE ASSOCIATES INC /MD/ | 71,052 | 235,000 | 0.51% | ||
| 28 | DRW Securities, LLC | 70,000 | 232,000 | 0.50% | ||
| 29 | Bank of New York Mellon Corp | 69,336 | 230,000 | 0.50% | ||
| 30 | EMERALD ACQUISITION LTD. | 62,915 | 208,000 | 0.45% | ||
| 31 | Virtu KCG Holdings LLC | 61,064 | 202,000 | 0.44% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,700 | 184,000 | 0.40% | Put | |
| 33 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,100 | 182,000 | 0.39% | Call | |
| 34 | DEUTSCHE BANK AG\ | 49,460 | 162,000 | 0.35% | ||
| 35 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 47,625 | 158,000 | 0.34% | ||
| 36 | JPMORGAN CHASE & CO | 45,690 | 151,000 | 0.33% | ||
| 37 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 44,572 | 148,000 | 0.32% | ||
| 38 | ROYAL BANK OF CANADA | 42,399 | 140,000 | 0.30% | ||
| 39 | RHUMBLINE ADVISERS | 34,992 | 116,000 | 0.25% | ||
| 40 | ALPS ADVISORS INC | 34,840 | 115,000 | 0.25% | ||
| 41 | MORGAN STANLEY | 32,469 | 107,000 | 0.23% | ||
| 42 | TEACHERS ADVISORS, LLC | 32,077 | 106,000 | 0.23% | ||
| 43 | GOLDMAN SACHS GROUP INC | 30,836 | 102,000 | 0.22% | ||
| 44 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 27,158 | 90,000 | 0.19% | ||
| 45 | AJO, LP | 26,602 | 88,000 | 0.19% | ||
| 46 | TFS CAPITAL LLC | 24,747 | 82,000 | 0.18% | ||
| 47 | GROUP ONE TRADING LLC | 21,718 | 72,000 | 0.16% | ||
| 48 | ProShare Advisors LLC | 19,491 | 65,000 | 0.14% | ||
| 49 | NEW YORK STATE COMMON RETIREMENT FUND | 16,000 | 53,000 | 0.11% | ||
| 50 | Nationwide Fund Advisors | 15,027 | 50,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
