| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,068,520 | 25,591,000 | 19.99% | ||
| 2 | FRANKLIN RESOURCES INC | 1,975,058 | 12,423,000 | 9.70% | ||
| 3 | STATE STREET CORP | 1,616,068 | 10,165,000 | 7.94% | ||
| 4 | Foresite Capital Management II, LLC | 1,488,410 | 9,362,000 | 7.31% | ||
| 5 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,099,700 | 6,917,000 | 5.40% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 843,665 | 5,307,000 | 4.15% | ||
| 7 | BlackRock Fund Advisors | 754,467 | 4,746,000 | 3.71% | ||
| 8 | FARALLON CAPITAL MANAGEMENT LLC | 658,800 | 4,144,000 | 3.24% | ||
| 9 | VANGUARD GROUP INC | 655,416 | 4,123,000 | 3.22% | ||
| 10 | VHCP Management, LLC | 541,480 | 3,406,000 | 2.66% | ||
| 11 | BOGLE INVESTMENT MANAGEMENT L P /DE/ | 421,996 | 2,654,000 | 2.07% | ||
| 12 | JPMORGAN CHASE & CO | 419,303 | 2,638,000 | 2.06% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 409,706 | 2,577,000 | 2.01% | ||
| 14 | Clearline Capital LP | 374,722 | 2,357,000 | 1.84% | ||
| 15 | EcoR1 Capital, LLC | 369,000 | 2,321,000 | 1.81% | ||
| 16 | Granahan Investment Management, LLC | 288,879 | 1,817,000 | 1.42% | ||
| 17 | PANAGORA ASSET MANAGEMENT INC | 246,060 | 1,548,000 | 1.21% | ||
| 18 | OXFORD ASSET MANAGEMENT LLP | 236,362 | 1,497,000 | 1.17% | ||
| 19 | AXA S.A. | 237,000 | 1,491,000 | 1.16% | ||
| 20 | DEUTSCHE BANK AG\ | 195,801 | 1,230,000 | 0.96% | ||
| 21 | NORTHERN TRUST CORP | 192,984 | 1,214,000 | 0.95% | ||
| 22 | Alyeska Investment Group, L.P. | 170,112 | 1,070,000 | 0.84% | ||
| 23 | A.R.T. Advisors, LLC | 169,521 | 1,066,000 | 0.83% | ||
| 24 | UBS Group AG | 155,430 | 978,000 | 0.76% | ||
| 25 | MORGAN STANLEY | 122,219 | 768,000 | 0.60% | ||
| 26 | Candriam S.C.A. | 120,400 | 757,000 | 0.59% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 116,187 | 730,000 | 0.57% | ||
| 28 | HARBOURVEST PARTNERS LLC | 111,894 | 704,000 | 0.55% | ||
| 29 | TUDOR INVESTMENT CORP ET AL | 111,765 | 703,000 | 0.55% | ||
| 30 | PRICE T ROWE ASSOCIATES INC /MD/ | 106,372 | 669,000 | 0.52% | ||
| 31 | MILLENNIUM MANAGEMENT LLC | 103,087 | 648,000 | 0.51% | ||
| 32 | Cubist Systematic Strategies, LLC | 93,968 | 591,000 | 0.46% | ||
| 33 | LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 93,848 | 590,000 | 0.46% | ||
| 34 | Spark Investment Management LLC | 91,500 | 575,000 | 0.45% | ||
| 35 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,000 | 572,000 | 0.45% | Put | |
| 36 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 84,253 | 530,000 | 0.41% | ||
| 37 | FT OPTIONS LLC | 79,780 | 502,000 | 0.39% | ||
| 38 | ALLIANCEBERNSTEIN L.P. | 15,540 | 497,000 | 0.39% | ||
| 39 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,800 | 496,000 | 0.39% | Call | |
| 40 | Bank of New York Mellon Corp | 75,063 | 473,000 | 0.37% | ||
| 41 | GREYLOCK XII GP LLC | 70,169 | 441,000 | 0.34% | ||
| 42 | DIMENSIONAL FUND ADVISORS LP | 65,485 | 412,000 | 0.32% | ||
| 43 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,076 | 390,000 | 0.30% | ||
| 44 | BlackRock Investment Management, LLC | 57,858 | 364,000 | 0.28% | ||
| 45 | Jefferies Group LLC | 57,900 | 364,000 | 0.28% | Call | |
| 46 | CREDIT SUISSE AG/ | 55,108 | 346,000 | 0.27% | ||
| 47 | GOLDMAN SACHS GROUP INC | 53,936 | 339,000 | 0.26% | ||
| 48 | Connor, Clark & Lunn Investment Management Ltd. | 52,825 | 332,000 | 0.26% | ||
| 49 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 47,853 | 301,000 | 0.24% | ||
| 50 | BALYASNY ASSET MANAGEMENT L.P. | 45,200 | 284,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
