| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,068,520 | 27,178,000 | 21.16% | ||
| 2 | DEERFIELD MANAGEMENT COMPANY, L.P. | 3,055,603 | 20,411,000 | 15.89% | ||
| 3 | FRANKLIN RESOURCES INC | 1,899,705 | 12,690,000 | 9.88% | ||
| 4 | Foresite Capital Management II, LLC | 1,422,273 | 9,501,000 | 7.40% | ||
| 5 | FORESITE CAPITAL MANAGEMENT III, LLC | 1,050,837 | 7,020,000 | 5.47% | ||
| 6 | FARALLON CAPITAL MANAGEMENT LLC | 838,800 | 5,603,000 | 4.36% | ||
| 7 | BlackRock Fund Advisors | 785,896 | 5,250,000 | 4.09% | ||
| 8 | VANGUARD GROUP INC | 681,512 | 4,553,000 | 3.54% | ||
| 9 | VHCP Management, LLC | 602,114 | 4,022,000 | 3.13% | ||
| 10 | BlackRock Institutional Trust Company, N.A. | 407,164 | 2,720,000 | 2.12% | ||
| 11 | JPMORGAN CHASE & CO | 391,285 | 2,614,000 | 2.04% | ||
| 12 | Granahan Investment Management, LLC | 363,029 | 2,425,000 | 1.89% | ||
| 13 | STATE STREET CORP | 340,113 | 2,270,000 | 1.77% | ||
| 14 | D. E. Shaw & Co., Inc. | 335,467 | 2,241,000 | 1.74% | ||
| 15 | DEUTSCHE BANK AG\ | 201,586 | 1,345,000 | 1.05% | ||
| 16 | NORTHERN TRUST CORP | 186,356 | 1,246,000 | 0.97% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 161,344 | 1,078,000 | 0.84% | ||
| 18 | A.R.T. Advisors, LLC | 161,521 | 1,078,000 | 0.84% | ||
| 19 | Alyeska Investment Group, L.P. | 154,786 | 1,034,000 | 0.81% | ||
| 20 | VHCP MANAGEMENT II, LLC | 141,479 | 945,000 | 0.74% | ||
| 21 | GEODE CAPITAL MANAGEMENT, LLC | 128,152 | 856,000 | 0.67% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 117,436 | 784,000 | 0.61% | ||
| 23 | HARBOURVEST PARTNERS LLC | 111,894 | 747,000 | 0.58% | ||
| 24 | Candriam S.C.A. | 108,000 | 718,000 | 0.56% | ||
| 25 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 105,400 | 704,000 | 0.55% | Call | |
| 26 | Bank of New York Mellon Corp | 93,842 | 627,000 | 0.49% | ||
| 27 | PRICE T ROWE ASSOCIATES INC /MD/ | 82,408 | 550,000 | 0.43% | ||
| 28 | MORGAN STANLEY | 75,950 | 507,000 | 0.39% | ||
| 29 | FT OPTIONS LLC | 69,440 | 464,000 | 0.36% | ||
| 30 | Squarepoint Ops LLC | 68,500 | 458,000 | 0.36% | ||
| 31 | DIMENSIONAL FUND ADVISORS LP | 65,472 | 437,000 | 0.34% | ||
| 32 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 61,796 | 413,000 | 0.32% | ||
| 33 | Connor, Clark & Lunn Investment Management Ltd. | 60,125 | 402,000 | 0.31% | ||
| 34 | BlackRock Investment Management, LLC | 58,812 | 393,000 | 0.31% | ||
| 35 | Jefferies Group LLC | 55,900 | 373,000 | 0.29% | Call | |
| 36 | CITADEL ADVISORS LLC | 54,527 | 364,000 | 0.28% | ||
| 37 | BALYASNY ASSET MANAGEMENT L.P. | 50,000 | 334,000 | 0.26% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 42,700 | 285,000 | 0.22% | Put | |
| 39 | TEACHERS ADVISORS, LLC | 36,372 | 243,000 | 0.19% | ||
| 40 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 35,821 | 239,000 | 0.19% | ||
| 41 | Cubist Systematic Strategies, LLC | 31,765 | 212,000 | 0.17% | ||
| 42 | ALPS ADVISORS INC | 30,629 | 205,000 | 0.16% | ||
| 43 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 29,573 | 198,000 | 0.15% | ||
| 44 | Princeton Alpha Management LP | 27,221 | 182,000 | 0.14% | ||
| 45 | CREDIT SUISSE AG/ | 26,727 | 178,000 | 0.14% | ||
| 46 | OXFORD ASSET MANAGEMENT LLP | 24,583 | 164,000 | 0.13% | ||
| 47 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 23,672 | 159,000 | 0.12% | ||
| 48 | Jefferies Group LLC | 23,559 | 157,000 | 0.12% | ||
| 49 | Swiss National Bank | 23,000 | 148,000 | 0.12% | ||
| 50 | ProShare Advisors LLC | 22,024 | 147,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
