| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,068,520 | 129,989,000 | 19.39% | ||
| 2 | FRANKLIN RESOURCES INC | 1,762,305 | 56,305,000 | 8.40% | ||
| 3 | JANUS HENDERSON INVESTORS US LLC | 1,288,644 | 41,172,000 | 6.14% | ||
| 4 | JENNISON ASSOCIATES LLC | 1,210,049 | 38,661,000 | 5.77% | ||
| 5 | WELLINGTON MANAGEMENT GROUP LLP | 1,200,014 | 38,341,000 | 5.72% | ||
| 6 | BlackRock Fund Advisors | 814,418 | 26,021,000 | 3.88% | ||
| 7 | Foresite Capital Management II, LLC | 811,300 | 25,921,000 | 3.87% | ||
| 8 | VANGUARD GROUP INC | 680,854 | 21,753,000 | 3.25% | ||
| 9 | RS INVESTMENT MANAGEMENT CO LLC | 596,110 | 19,046,000 | 2.84% | ||
| 10 | DEERFIELD MANAGEMENT COMPANY, L.P. | 553,472 | 17,683,000 | 2.64% | ||
| 11 | VHCP Management, LLC | 541,480 | 17,300,000 | 2.58% | ||
| 12 | Capital World Investors | 512,644 | 16,379,000 | 2.44% | ||
| 13 | Tourbillon Capital Partners, L.P. | 458,758 | 14,657,000 | 2.19% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 447,389 | 14,294,000 | 2.13% | ||
| 15 | ALPS ADVISORS INC | 42,418 | 13,553,000 | 2.02% | ||
| 16 | LOOMIS SAYLES & CO L P | 411,859 | 13,159,000 | 1.96% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 405,255 | 12,948,000 | 1.93% | ||
| 18 | BAKER BROS. ADVISORS LP | 390,346 | 12,472,000 | 1.86% | ||
| 19 | Granahan Investment Management, LLC | 363,007 | 11,598,000 | 1.73% | ||
| 20 | AXA S.A. | 261,536 | 8,356,000 | 1.25% | ||
| 21 | FARALLON CAPITAL MANAGEMENT LLC | 231,300 | 7,390,000 | 1.10% | ||
| 22 | NORTHERN TRUST CORP | 214,412 | 6,851,000 | 1.02% | ||
| 23 | Third Rock Ventures, LLC | 210,371 | 6,721,000 | 1.00% | ||
| 24 | BLACKROCK ADVISORS LLC | 203,933 | 6,516,000 | 0.97% | ||
| 25 | JPMORGAN CHASE & CO | 190,735 | 6,094,000 | 0.91% | ||
| 26 | LORD, ABBETT & CO. LLC | 163,163 | 5,213,000 | 0.78% | ||
| 27 | HAMILTON LANE ADVISORS LLC | 124,940 | 3,992,000 | 0.60% | ||
| 28 | Candriam S.C.A. | 120,400 | 3,847,000 | 0.57% | ||
| 29 | GEODE CAPITAL MANAGEMENT, LLC | 118,622 | 3,789,000 | 0.57% | ||
| 30 | Asset Management One Co., Ltd. | 121,042 | 3,783,000 | 0.56% | ||
| 31 | MACQUARIE GROUP LTD | 114,316 | 3,652,000 | 0.54% | ||
| 32 | HARBOURVEST PARTNERS LLC | 111,894 | 3,575,000 | 0.53% | ||
| 33 | DEUTSCHE BANK AG\ | 110,269 | 3,521,000 | 0.53% | ||
| 34 | Lombard Odier Asset Management (USA) Corp | 107,287 | 3,428,000 | 0.51% | ||
| 35 | BELLEVUE ASSET MANAGEMENT AG | 100,000 | 3,195,000 | 0.48% | ||
| 36 | Bank of New York Mellon Corp | 75,121 | 2,400,000 | 0.36% | ||
| 37 | BlackRock Investment Management, LLC | 70,488 | 2,252,000 | 0.34% | ||
| 38 | Ghost Tree Capital, LLC | 65,000 | 2,077,000 | 0.31% | ||
| 39 | PRINCIPAL FINANCIAL GROUP INC | 63,290 | 2,022,000 | 0.30% | ||
| 40 | TIAA CREF INVESTMENT MANAGEMENT LLC | 62,076 | 1,983,000 | 0.30% | ||
| 41 | AQR CAPITAL MANAGEMENT LLC | 61,656 | 1,970,000 | 0.29% | ||
| 42 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 58,900 | 1,882,000 | 0.28% | Put | |
| 43 | EMERALD MUTUAL FUND ADVISERS TRUST | 55,000 | 1,757,000 | 0.26% | ||
| 44 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 52,996 | 1,694,000 | 0.25% | ||
| 45 | ACUTA CAPITAL PARTNERS, LLC | 51,519 | 1,646,000 | 0.25% | ||
| 46 | BALYASNY ASSET MANAGEMENT L.P. | 48,342 | 1,545,000 | 0.23% | ||
| 47 | MORGAN STANLEY | 45,904 | 1,467,000 | 0.22% | ||
| 48 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,324 | 1,288,000 | 0.19% | ||
| 49 | SPHERA FUNDS MANAGEMENT LTD. | 40,000 | 1,278,000 | 0.19% | ||
| 50 | Iguana Healthcare Management, LLC | 40,000 | 1,278,000 | 0.19% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
