| 1 |
FMR LLC |
4,068,520 |
24,370,000 |
23.48% |
|
|
| 2 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
3,055,603 |
18,303,000 |
17.64% |
|
|
| 3 |
BlackRock Fund Advisors |
929,566 |
5,568,000 |
5.37% |
|
|
| 4 |
FARALLON CAPITAL MANAGEMENT LLC |
838,800 |
5,024,000 |
4.84% |
|
|
| 5 |
VANGUARD GROUP INC |
805,362 |
4,824,000 |
4.65% |
|
|
| 6 |
Foresite Capital Management II, LLC |
760,046 |
4,553,000 |
4.39% |
|
|
| 7 |
BALYASNY ASSET MANAGEMENT L.P. |
737,103 |
4,415,000 |
4.25% |
|
|
| 8 |
VHCP Management, LLC |
602,114 |
3,607,000 |
3.48% |
|
|
| 9 |
FORESITE CAPITAL MANAGEMENT III, LLC |
537,495 |
3,220,000 |
3.10% |
|
|
| 10 |
Granahan Investment Management, LLC |
530,039 |
3,175,000 |
3.06% |
|
|
| 11 |
BlackRock Institutional Trust Company, N.A. |
503,109 |
3,014,000 |
2.90% |
|
|
| 12 |
D. E. Shaw & Co., Inc. |
420,305 |
2,518,000 |
2.43% |
|
|
| 13 |
STATE STREET CORP |
338,678 |
2,026,000 |
1.95% |
|
|
| 14 |
BRIDGEWAY CAPITAL MANAGEMENT, LLC |
276,300 |
1,655,000 |
1.59% |
|
|
| 15 |
DEUTSCHE BANK AG\ |
207,485 |
1,241,000 |
1.20% |
|
|
| 16 |
Spark Investment Management LLC |
200,300 |
1,199,000 |
1.16% |
|
|
| 17 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
164,731 |
987,000 |
0.95% |
|
|
| 18 |
NORTHERN TRUST CORP |
158,274 |
948,000 |
0.91% |
|
|
| 19 |
Alyeska Investment Group, L.P. |
157,993 |
946,000 |
0.91% |
|
|
| 20 |
VHCP MANAGEMENT II, LLC |
141,479 |
847,000 |
0.82% |
|
|
| 21 |
GEODE CAPITAL MANAGEMENT, LLC |
139,390 |
834,000 |
0.80% |
|
|
| 22 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
113,600 |
680,000 |
0.66% |
Call |
|
| 23 |
MORGAN STANLEY |
111,723 |
670,000 |
0.65% |
|
|
| 24 |
HARBOURVEST PARTNERS LLC |
111,894 |
670,000 |
0.65% |
|
|
| 25 |
Candriam S.C.A. |
108,000 |
647,000 |
0.62% |
|
|
| 26 |
BlackRock Investment Management, LLC |
89,327 |
535,000 |
0.52% |
|
|
| 27 |
Bank of New York Mellon Corp |
86,114 |
515,000 |
0.50% |
|
|
| 28 |
FEDERATED HERMES, INC. |
84,777 |
508,000 |
0.49% |
|
|
| 29 |
Connor, Clark & Lunn Investment Management Ltd. |
77,425 |
464,000 |
0.45% |
|
|
| 30 |
PRICE T ROWE ASSOCIATES INC /MD/ |
71,052 |
426,000 |
0.41% |
|
|
| 31 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
70,172 |
421,000 |
0.41% |
|
|
| 32 |
A.R.T. Advisors, LLC |
68,512 |
410,000 |
0.40% |
|
|
| 33 |
MILLENNIUM MANAGEMENT LLC |
57,324 |
343,000 |
0.33% |
|
|
| 34 |
JPMORGAN CHASE & CO |
48,510 |
291,000 |
0.28% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
47,925 |
287,000 |
0.28% |
|
|
| 36 |
ROYAL BANK OF CANADA |
44,597 |
268,000 |
0.26% |
|
|
| 37 |
CREDIT SUISSE AG/ |
39,235 |
234,000 |
0.23% |
|
|
| 38 |
ALPS ADVISORS INC |
38,312 |
229,000 |
0.22% |
|
|
| 39 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
38,200 |
229,000 |
0.22% |
Put |
|
| 40 |
RHUMBLINE ADVISERS |
34,692 |
208,000 |
0.20% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
32,077 |
192,000 |
0.19% |
|
|
| 42 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
29,573 |
177,000 |
0.17% |
|
|
| 43 |
Cubist Systematic Strategies, LLC |
25,103 |
150,000 |
0.14% |
|
|
| 44 |
FT OPTIONS LLC |
24,930 |
149,000 |
0.14% |
|
|
| 45 |
ProShare Advisors LLC |
23,099 |
138,000 |
0.13% |
|
|
| 46 |
SUSQUEHANNA INTERNATIONAL GROUP, LLP |
21,235 |
127,000 |
0.12% |
|
|
| 47 |
BELLEVUE GROUP AG |
20,000 |
120,000 |
0.12% |
|
|
| 48 |
DIMENSIONAL FUND ADVISORS LP |
19,791 |
119,000 |
0.11% |
|
|
| 49 |
ALLIANCEBERNSTEIN L.P. |
19,100 |
114,000 |
0.11% |
|
|
| 50 |
GOLDMAN SACHS GROUP INC |
16,180 |
97,000 |
0.09% |
|
|
