| 1 |
Third Rock Ventures, LLC |
5,602,045 |
172,767,000 |
34.56% |
|
|
| 2 |
FMR LLC |
3,406,049 |
105,043,000 |
21.02% |
|
|
| 3 |
FRANKLIN RESOURCES INC |
736,671 |
22,719,000 |
4.55% |
|
|
| 4 |
RA CAPITAL MANAGEMENT, L.P. |
732,960 |
22,604,000 |
4.52% |
|
|
| 5 |
Capital World Investors |
541,729 |
20,591,000 |
4.12% |
|
|
| 6 |
Bain Capital Public Equity Management, LLC |
666,480 |
20,554,000 |
4.11% |
|
|
| 7 |
VHCP Management, LLC |
541,480 |
16,699,000 |
3.34% |
|
|
| 8 |
Foresite Capital Management II, LLC |
500,166 |
15,425,000 |
3.09% |
|
|
| 9 |
WELLINGTON MANAGEMENT GROUP LLP |
498,855 |
15,385,000 |
3.08% |
|
|
| 10 |
BlackRock Fund Advisors |
458,052 |
14,126,000 |
2.83% |
|
|
| 11 |
JENNISON ASSOCIATES LLC |
292,052 |
9,007,000 |
1.80% |
|
|
| 12 |
PERCEPTIVE ADVISORS LLC |
278,313 |
8,583,000 |
1.72% |
|
|
| 13 |
VANGUARD GROUP INC |
204,328 |
6,301,000 |
1.26% |
|
|
| 14 |
Alyeska Investment Group, L.P. |
123,419 |
3,806,000 |
0.76% |
|
|
| 15 |
SABBY MANAGEMENT, LLC |
111,259 |
3,431,000 |
0.69% |
|
|
| 16 |
JPMORGAN CHASE & CO |
109,025 |
3,363,000 |
0.67% |
|
|
| 17 |
Lombard Odier Asset Management (USA) Corp |
108,186 |
3,336,000 |
0.67% |
|
|
| 18 |
Granahan Investment Management, LLC |
108,130 |
3,335,000 |
0.67% |
|
|
| 19 |
ACUTA CAPITAL PARTNERS, LLC |
100,263 |
3,092,000 |
0.62% |
|
|
| 20 |
PRINCIPAL FINANCIAL GROUP INC |
97,700 |
3,013,000 |
0.60% |
|
|
| 21 |
SPHERA FUNDS MANAGEMENT LTD. |
72,100 |
2,224,000 |
0.44% |
|
|
| 22 |
NORTHERN TRUST CORP |
71,824 |
2,215,000 |
0.44% |
|
|
| 23 |
STATE STREET CORP |
64,548 |
1,990,000 |
0.40% |
|
|
| 24 |
BlackRock Institutional Trust Company, N.A. |
60,494 |
1,866,000 |
0.37% |
|
|
| 25 |
GOLDMAN SACHS GROUP INC |
60,182 |
1,856,000 |
0.37% |
|
|
| 26 |
FARALLON CAPITAL MANAGEMENT LLC |
60,000 |
1,850,000 |
0.37% |
|
|
| 27 |
Lisanti Capital Growth, LLC |
56,487 |
1,742,000 |
0.35% |
|
|
| 28 |
DEUTSCHE BANK AG\ |
43,280 |
1,333,000 |
0.27% |
|
|
| 29 |
GEODE CAPITAL MANAGEMENT, LLC |
37,152 |
1,145,000 |
0.23% |
|
|
| 30 |
EMERALD MUTUAL FUND ADVISERS TRUST |
35,000 |
1,079,000 |
0.22% |
|
|
| 31 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
31,608 |
975,000 |
0.20% |
|
|
| 32 |
Bank of New York Mellon Corp |
30,707 |
947,000 |
0.19% |
|
|
| 33 |
Weiss Multi-Strategy Advisers LLC |
30,000 |
925,000 |
0.19% |
|
|
| 34 |
Tekla Capital Management LLC |
26,614 |
821,000 |
0.16% |
|
|
| 35 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
20,900 |
645,000 |
0.13% |
|
|
| 36 |
COMMONWEALTH OF PENNSYLVANIA PUBLIC SCHOOL EMPLS RETRMT SYS |
20,425 |
630,000 |
0.13% |
|
|
| 37 |
BlackRock Investment Management, LLC |
19,821 |
611,000 |
0.12% |
|
|
| 38 |
COMMONWEALTH BANK OF AUSTRALIA |
19,500 |
601,000 |
0.12% |
|
|
| 39 |
Nationwide Fund Advisors |
17,082 |
527,000 |
0.11% |
|
|
| 40 |
ProShare Advisors LLC |
16,515 |
509,000 |
0.10% |
|
|
| 41 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
12,754 |
393,000 |
0.08% |
|
|
| 42 |
CREDIT SUISSE AG/ |
8,933 |
275,000 |
0.06% |
|
|
| 43 |
CHARLES SCHWAB INVESTMENT MANAGEMENT INC |
8,500 |
263,000 |
0.05% |
|
|
| 44 |
Swiss National Bank |
6,800 |
210,000 |
0.04% |
|
|
| 45 |
TEACHERS ADVISORS, LLC |
6,431 |
198,000 |
0.04% |
|
|
| 46 |
CITIGROUP INC |
5,937 |
183,000 |
0.04% |
|
|
| 47 |
AMERICAN INTERNATIONAL GROUP, INC. |
4,339 |
133,815 |
0.03% |
|
|
| 48 |
MANUFACTURERS LIFE INSURANCE COMPANY, THE |
3,327 |
103,000 |
0.02% |
|
|
| 49 |
SG Americas Securities, LLC |
3,268 |
101,000 |
0.02% |
|
|
| 50 |
BLACKROCK ADVISORS LLC |
2,652 |
82,000 |
0.02% |
|
|
