| 1 |
Third Rock Ventures, LLC |
4,202,045 |
166,443,000 |
18.92% |
|
|
| 2 |
FMR LLC |
3,920,252 |
155,281,000 |
17.65% |
|
|
| 3 |
Foresite Capital Management II, LLC |
3,511,456 |
56,497,000 |
6.42% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
1,050,178 |
41,598,000 |
4.73% |
|
|
| 5 |
JENNISON ASSOCIATES LLC |
953,610 |
37,772,000 |
4.29% |
|
|
| 6 |
JANUS HENDERSON INVESTORS US LLC |
789,172 |
31,259,000 |
3.55% |
|
|
| 7 |
FRANKLIN RESOURCES INC |
780,184 |
30,903,000 |
3.51% |
|
|
| 8 |
RA CAPITAL MANAGEMENT, L.P. |
732,960 |
29,033,000 |
3.30% |
|
|
| 9 |
Bain Capital Public Equity Management, LLC |
666,480 |
26,399,000 |
3.00% |
|
|
| 10 |
Capital World Investors |
605,000 |
23,964,000 |
2.72% |
|
|
| 11 |
STATE STREET CORP |
590,468 |
23,388,000 |
2.66% |
|
|
| 12 |
BlackRock Fund Advisors |
550,891 |
21,821,000 |
2.48% |
|
|
| 13 |
VHCP Management, LLC |
541,480 |
21,448,000 |
2.44% |
|
|
| 14 |
PRICE T ROWE ASSOCIATES INC /MD/ |
532,564 |
21,095,000 |
2.40% |
|
|
| 15 |
WELLINGTON MANAGEMENT GROUP LLP |
523,198 |
20,724,000 |
2.36% |
|
|
| 16 |
VANGUARD GROUP INC |
366,314 |
14,510,000 |
1.65% |
|
|
| 17 |
Granahan Investment Management, LLC |
327,727 |
12,981,000 |
1.48% |
|
|
| 18 |
LOOMIS SAYLES & CO L P |
325,231 |
12,883,000 |
1.46% |
|
|
| 19 |
RS INVESTMENT MANAGEMENT CO LLC |
316,090 |
12,520,000 |
1.42% |
|
|
| 20 |
Visium Asset Management, LP |
223,413 |
8,849,000 |
1.01% |
|
|
| 21 |
BLACKROCK ADVISORS LLC |
197,595 |
7,827,000 |
0.89% |
|
|
| 22 |
Pier Capital, LLC |
168,378 |
6,669,000 |
0.76% |
|
|
| 23 |
Lombard Odier Asset Management (USA) Corp |
138,131 |
5,471,000 |
0.62% |
|
|
| 24 |
FARALLON CAPITAL MANAGEMENT LLC |
130,000 |
5,149,000 |
0.59% |
|
|
| 25 |
BlackRock Institutional Trust Company, N.A. |
125,756 |
4,981,000 |
0.57% |
|
|
| 26 |
Asset Management One Co., Ltd. |
122,378 |
4,913,000 |
0.56% |
|
|
| 27 |
JPMORGAN CHASE & CO |
107,115 |
4,242,000 |
0.48% |
|
|
| 28 |
Spark Investment Management LLC |
101,636 |
4,023,000 |
0.46% |
|
|
| 29 |
HARBOURVEST PARTNERS LLC |
101,134 |
4,006,000 |
0.46% |
|
|
| 30 |
Candriam S.C.A. |
100,000 |
3,962,000 |
0.45% |
|
|
| 31 |
ACUTA CAPITAL PARTNERS, LLC |
100,000 |
3,961,000 |
0.45% |
|
|
| 32 |
NORTHERN TRUST CORP |
96,389 |
3,818,000 |
0.43% |
|
|
| 33 |
BAKER BROS. ADVISORS LP |
94,745 |
3,753,000 |
0.43% |
|
|
| 34 |
GEODE CAPITAL MANAGEMENT, LLC |
82,239 |
3,257,000 |
0.37% |
|
|
| 35 |
RENAISSANCE TECHNOLOGIES LLC |
78,371 |
3,104,000 |
0.35% |
|
|
| 36 |
EverPoint Asset Management, LLC |
75,000 |
2,971,000 |
0.34% |
|
|
| 37 |
HAMILTON LANE ADVISORS LLC |
74,941 |
2,968,000 |
0.34% |
|
|
| 38 |
PRINCIPAL FINANCIAL GROUP INC |
56,400 |
2,234,000 |
0.25% |
|
|
| 39 |
Bank of New York Mellon Corp |
49,107 |
1,945,000 |
0.22% |
|
|
| 40 |
EMERALD MUTUAL FUND ADVISERS TRUST |
55,000 |
1,884,000 |
0.21% |
|
|
| 41 |
OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) |
40,000 |
1,584,000 |
0.18% |
|
|
| 42 |
CITADEL ADVISORS LLC |
39,472 |
1,564,000 |
0.18% |
|
|
| 43 |
COLUMBUS CIRCLE INVESTORS |
38,121 |
1,510,000 |
0.17% |
|
|
| 44 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
37,024 |
1,467,000 |
0.17% |
|
|
| 45 |
BlackRock Investment Management, LLC |
36,200 |
1,434,000 |
0.16% |
|
|
| 46 |
UNITED SERVICES AUTOMOBILE ASSOCIATION |
34,873 |
1,381,000 |
0.16% |
|
|
| 47 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
30,830 |
1,221,000 |
0.14% |
|
|
| 48 |
BlackRock Finance, Inc. |
30,262 |
1,199,000 |
0.14% |
|
|
| 49 |
MARSHALL WACE, LLP |
26,375 |
1,045,000 |
0.12% |
|
|
| 50 |
CREDIT SUISSE AG/ |
25,340 |
1,004,000 |
0.11% |
|
|
