| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | CITIGROUP INC | 1 | 0 | 0.00% | ||
| 2 | BARCLAYS PLC | 40 | 1,000 | 0.00% | ||
| 3 | UBS Group AG | 74 | 1,000 | 0.00% | ||
| 4 | ADVANTAGE INVESTMENT MANAGEMENT, LLC | 300 | 5,000 | 0.00% | ||
| 5 | GLENMEDE TRUST CO NA | 290 | 5,000 | 0.00% | ||
| 6 | MORGAN STANLEY | 353 | 6,000 | 0.00% | ||
| 7 | ROYAL BANK OF CANADA | 364 | 6,000 | 0.00% | ||
| 8 | Tower Research Capital LLC (TRC) | 953 | 17,000 | 0.01% | ||
| 9 | WELLS FARGO & COMPANY/MN | 1,032 | 18,000 | 0.01% | ||
| 10 | BNP PARIBAS FINANCIAL MARKETS | 1,667 | 29,139 | 0.01% | ||
| 11 | BANK OF AMERICA CORP /DE/ | 2,003 | 35,000 | 0.01% | ||
| 12 | AMERICAN INTERNATIONAL GROUP, INC. | 4,566 | 80,000 | 0.03% | ||
| 13 | MANUFACTURERS LIFE INSURANCE COMPANY, THE | 4,823 | 84,000 | 0.03% | ||
| 14 | PANAGORA ASSET MANAGEMENT INC | 5,088 | 89,000 | 0.03% | ||
| 15 | BlackRock Group LTD | 7,924 | 139,000 | 0.05% | ||
| 16 | NEW YORK STATE COMMON RETIREMENT FUND | 10,750 | 188,000 | 0.07% | ||
| 17 | TEACHERS ADVISORS, LLC | 11,552 | 202,000 | 0.08% | ||
| 18 | DAFNA Capital Management LLC | 11,745 | 205,000 | 0.08% | ||
| 19 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 14,213 | 248,000 | 0.10% | ||
| 20 | Nationwide Fund Advisors | 14,958 | 261,000 | 0.10% | ||
| 21 | A.R.T. Advisors, LLC | 25,584 | 447,000 | 0.17% | ||
| 22 | TIAA CREF INVESTMENT MANAGEMENT LLC | 25,788 | 451,000 | 0.17% | ||
| 23 | BlackRock Investment Management, LLC | 29,314 | 512,000 | 0.20% | ||
| 24 | BRIDGEWAY CAPITAL MANAGEMENT, LLC | 30,000 | 524,000 | 0.20% | ||
| 25 | Bank of New York Mellon Corp | 33,917 | 593,000 | 0.23% | ||
| 26 | RUSSELL FRANK CO/ | 35,995 | 629,000 | 0.24% | ||
| 27 | BLACKROCK ADVISORS LLC | 36,038 | 630,000 | 0.24% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 44,242 | 773,000 | 0.30% | ||
| 29 | DEUTSCHE BANK AG\ | 46,168 | 806,000 | 0.31% | ||
| 30 | STATE STREET CORP | 52,505 | 916,000 | 0.35% | ||
| 31 | Spark Investment Management LLC | 53,800 | 938,000 | 0.36% | ||
| 32 | Nicholas Investment Partners, LP | 54,381 | 951,000 | 0.37% | ||
| 33 | NORTHERN TRUST CORP | 68,022 | 1,189,000 | 0.46% | ||
| 34 | AWM Investment Company, Inc. | 75,000 | 1,311,000 | 0.51% | ||
| 35 | Invesco Ltd. | 80,845 | 1,413,000 | 0.55% | ||
| 36 | BAKER BROS. ADVISORS LP | 100,000 | 1,748,000 | 0.68% | ||
| 37 | BlackRock Institutional Trust Company, N.A. | 118,904 | 2,078,000 | 0.81% | ||
| 38 | Informed Momentum Co LLC | 122,552 | 2,142,000 | 0.83% | ||
| 39 | VANGUARD GROUP INC | 157,159 | 2,747,000 | 1.06% | ||
| 40 | BlackRock Fund Advisors | 194,861 | 3,406,000 | 1.32% | ||
| 41 | FMR LLC | 230,286 | 4,025,000 | 1.56% | ||
| 42 | AXA S.A. | 286,950 | 5,016,000 | 1.94% | ||
| 43 | EVENTIDE ASSET MANAGEMENT, LLC | 339,200 | 5,929,000 | 2.30% | ||
| 44 | Visium Asset Management, LP | 400,000 | 6,992,000 | 2.71% | ||
| 45 | DRIEHAUS CAPITAL MANAGEMENT LLC | 440,426 | 7,699,000 | 2.98% | ||
| 46 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,088,225 | 19,022,000 | 7.37% | ||
| 47 | BVF INC/IL | 1,531,108 | 26,764,000 | 10.37% | ||
| 48 | RS INVESTMENT MANAGEMENT CO LLC | 1,549,300 | 27,082,000 | 10.49% | ||
| 49 | NEA Management Company, LLC | 1,792,207 | 31,328,000 | 12.14% | ||
| 50 | ORBIMED ADVISORS LLC | 2,175,857 | 38,034,000 | 14.74% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
