| 1 |
Third Rock Ventures, LLC |
11,681,008 |
367,952,000 |
61.79% |
|
|
| 2 |
FMR LLC |
3,856,789 |
121,489,000 |
20.40% |
|
|
| 3 |
ORBIMED ADVISORS LLC |
537,335 |
16,926,000 |
2.84% |
|
|
| 4 |
DEERFIELD MANAGEMENT COMPANY, L.P. |
450,667 |
14,196,000 |
2.38% |
|
|
| 5 |
RS INVESTMENT MANAGEMENT CO LLC |
289,100 |
9,107,000 |
1.53% |
|
|
| 6 |
ALLIANCEBERNSTEIN L.P. |
254,852 |
8,028,000 |
1.35% |
|
|
| 7 |
PERCEPTIVE ADVISORS LLC |
208,676 |
6,573,000 |
1.10% |
|
|
| 8 |
FEDERATED HERMES, INC. |
204,200 |
6,432,000 |
1.08% |
|
|
| 9 |
FRANKLIN RESOURCES INC |
200,000 |
6,300,000 |
1.06% |
|
|
| 10 |
BlackRock Fund Advisors |
141,607 |
4,461,000 |
0.75% |
|
|
| 11 |
Alyeska Investment Group, L.P. |
99,674 |
3,140,000 |
0.53% |
|
|
| 12 |
SPHERA FUNDS MANAGEMENT LTD. |
87,924 |
2,770,000 |
0.47% |
|
|
| 13 |
MILLENNIUM MANAGEMENT LLC |
80,078 |
2,522,000 |
0.42% |
|
|
| 14 |
BAKER BROS. ADVISORS LP |
75,000 |
2,363,000 |
0.40% |
|
|
| 15 |
Nicholas Investment Partners, LP |
64,185 |
2,022,000 |
0.34% |
|
|
| 16 |
JPMORGAN CHASE & CO |
58,775 |
1,851,000 |
0.31% |
|
|
| 17 |
GOLDMAN SACHS GROUP INC |
58,136 |
1,831,000 |
0.31% |
|
|
| 18 |
BlackRock Institutional Trust Company, N.A. |
53,644 |
1,690,000 |
0.28% |
|
|
| 19 |
STATE STREET CORP |
48,100 |
1,515,000 |
0.25% |
|
|
| 20 |
CITADEL ADVISORS LLC |
41,037 |
1,293,000 |
0.22% |
|
|
| 21 |
EVENTIDE ASSET MANAGEMENT, LLC |
40,200 |
1,266,000 |
0.21% |
|
|
| 22 |
BLACKROCK ADVISORS LLC |
37,750 |
1,189,000 |
0.20% |
|
|
| 23 |
UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC |
37,600 |
1,184,000 |
0.20% |
|
|
| 24 |
VANGUARD GROUP INC |
32,525 |
1,024,000 |
0.17% |
|
|
| 25 |
Bank of New York Mellon Corp |
28,595 |
901,000 |
0.15% |
|
|
| 26 |
GEODE CAPITAL MANAGEMENT, LLC |
24,729 |
778,000 |
0.13% |
|
|
| 27 |
LANDSCAPE CAPITAL MANAGEMENT, L.L.C. |
22,116 |
697,000 |
0.12% |
|
|
| 28 |
CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM |
18,850 |
594,000 |
0.10% |
|
|
| 29 |
ARTHUR M. COHEN & ASSOCIATES, LLC |
8,281 |
589,000 |
0.10% |
|
|
| 30 |
BlackRock Group LTD |
18,262 |
576,000 |
0.10% |
|
|
| 31 |
DEUTSCHE BANK AG\ |
17,801 |
560,000 |
0.09% |
|
|
| 32 |
BlackRock Investment Management, LLC |
17,460 |
550,000 |
0.09% |
|
|
| 33 |
NORTHERN TRUST CORP |
13,911 |
439,000 |
0.07% |
|
|
| 34 |
TIAA CREF INVESTMENT MANAGEMENT LLC |
12,297 |
387,000 |
0.06% |
|
|
| 35 |
CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM |
10,600 |
334,000 |
0.06% |
|
|
| 36 |
Cormorant Asset Management, LP |
10,000 |
315,000 |
0.05% |
|
|
| 37 |
Hutchin Hill Capital, LP |
10,000 |
315,000 |
0.05% |
|
|
| 38 |
METROPOLITAN LIFE INSURANCE CO/NY |
8,277 |
261,000 |
0.04% |
|
|
| 39 |
BlackRock Finance, Inc. |
6,900 |
217,000 |
0.04% |
|
|
| 40 |
Cubist Systematic Strategies, LLC |
6,895 |
217,000 |
0.04% |
|
|
| 41 |
TEACHERS ADVISORS, LLC |
5,360 |
169,000 |
0.03% |
|
|
| 42 |
Nationwide Fund Advisors |
5,191 |
164,000 |
0.03% |
|
|
| 43 |
Tekla Capital Management LLC |
5,000 |
158,000 |
0.03% |
|
|
| 44 |
STRS OHIO |
2,000 |
63,000 |
0.01% |
|
|
| 45 |
MORGAN STANLEY |
1,845 |
58,000 |
0.01% |
|
|
| 46 |
MANAGED ACCOUNT ADVISORS LLC |
595 |
19,000 |
0.00% |
|
|
| 47 |
BlackRock Japan Co. Ltd |
402 |
13,000 |
0.00% |
|
|
| 48 |
Tower Research Capital LLC (TRC) |
252 |
8,000 |
0.00% |
|
|
| 49 |
CITIGROUP INC |
201 |
6,000 |
0.00% |
|
|
| 50 |
Creative Planning |
100 |
3,000 |
0.00% |
|
|
