| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,798,228 | 153,831,000 | 16.42% | ||
| 2 | VANGUARD GROUP INC | 1,621,375 | 51,981,000 | 5.55% | ||
| 3 | Visium Asset Management, LP | 1,559,922 | 50,012,000 | 5.34% | ||
| 4 | FRANKLIN RESOURCES INC | 1,287,805 | 41,287,000 | 4.41% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 1,113,654 | 35,704,000 | 3.81% | ||
| 6 | Redmile Group, LLC | 1,053,018 | 33,760,000 | 3.60% | ||
| 7 | JPMORGAN CHASE & CO | 1,025,990 | 32,893,000 | 3.51% | ||
| 8 | ALLIANCEBERNSTEIN L.P. | 947,562 | 30,379,000 | 3.24% | ||
| 9 | Cormorant Asset Management, LP | 945,000 | 30,297,000 | 3.23% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 846,605 | 27,142,000 | 2.90% | ||
| 11 | BB BIOTECH AG | 833,663 | 26,727,000 | 2.85% | ||
| 12 | BlackRock Fund Advisors | 787,546 | 25,249,000 | 2.70% | ||
| 13 | OppenheimerFunds, Inc. | 749,566 | 24,031,000 | 2.57% | ||
| 14 | STATE STREET CORP | 724,957 | 23,245,000 | 2.48% | ||
| 15 | OAK RIDGE INVESTMENTS LLC | 653,153 | 20,940,000 | 2.24% | ||
| 16 | RS INVESTMENT MANAGEMENT CO LLC | 576,391 | 18,479,000 | 1.97% | ||
| 17 | LORD, ABBETT & CO. LLC | 531,404 | 17,037,000 | 1.82% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 523,461 | 16,782,000 | 1.79% | ||
| 19 | Granahan Investment Management, LLC | 486,985 | 15,613,000 | 1.67% | ||
| 20 | CITADEL ADVISORS LLC | 485,511 | 15,565,000 | 1.66% | ||
| 21 | JENNISON ASSOCIATES LLC | 431,545 | 13,835,000 | 1.48% | ||
| 22 | SECTORAL ASSET MANAGEMENT INC | 421,084 | 13,500,000 | 1.44% | ||
| 23 | BlackRock Institutional Trust Company, N.A. | 395,666 | 12,685,000 | 1.35% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 381,525 | 12,232,000 | 1.31% | ||
| 25 | GILDER GAGNON HOWE & CO LLC | 351,105 | 11,256,000 | 1.20% | ||
| 26 | DEUTSCHE BANK AG\ | 294,571 | 9,443,000 | 1.01% | ||
| 27 | FEDERATED HERMES, INC. | 245,000 | 7,855,000 | 0.84% | ||
| 28 | BAKER BROS. ADVISORS LP | 224,048 | 7,183,000 | 0.77% | ||
| 29 | PFM Health Sciences, LP | 198,058 | 6,350,000 | 0.68% | ||
| 30 | CASDIN CAPITAL, LLC | 189,000 | 6,059,000 | 0.65% | ||
| 31 | NORGES BANK | 185,566 | 5,949,000 | 0.64% | ||
| 32 | NORTHERN TRUST CORP | 182,223 | 5,842,000 | 0.62% | ||
| 33 | EVENTIDE ASSET MANAGEMENT, LLC | 170,000 | 5,450,000 | 0.58% | ||
| 34 | Opaleye Management Inc. | 165,000 | 5,290,000 | 0.56% | ||
| 35 | Ghost Tree Capital, LLC | 160,000 | 5,130,000 | 0.55% | ||
| 36 | Polar Capital LLP | 160,000 | 5,130,000 | 0.55% | ||
| 37 | Tekla Capital Management LLC | 146,800 | 4,706,000 | 0.50% | ||
| 38 | New Leaf Venture Partners, L.L.C. | 142,570 | 4,571,000 | 0.49% | ||
| 39 | SPHERA FUNDS MANAGEMENT LTD. | 123,000 | 3,943,000 | 0.42% | ||
| 40 | BLACKROCK ADVISORS LLC | 120,315 | 3,857,000 | 0.41% | ||
| 41 | GEODE CAPITAL MANAGEMENT, LLC | 119,750 | 3,839,000 | 0.41% | ||
| 42 | CLARIUS GROUP, LLC | 110,950 | 3,557,000 | 0.38% | ||
| 43 | HARBOURVEST PARTNERS LLC | 104,568 | 3,352,000 | 0.36% | ||
| 44 | J. Goldman & Co LP | 102,000 | 3,270,000 | 0.35% | ||
| 45 | SABBY MANAGEMENT, LLC | 100,000 | 3,206,000 | 0.34% | ||
| 46 | Bank of New York Mellon Corp | 92,032 | 2,950,000 | 0.31% | ||
| 47 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 88,992 | 2,853,000 | 0.30% | ||
| 48 | GAM Holding AG | 79,400 | 2,546,000 | 0.27% | ||
| 49 | GOLDMAN SACHS GROUP INC | 79,324 | 2,543,000 | 0.27% | ||
| 50 | Alyeska Investment Group, L.P. | 78,917 | 2,530,000 | 0.27% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
