| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,328,270 | 252,338,000 | 18.47% | ||
| 2 | VANGUARD GROUP INC | 1,331,977 | 77,654,000 | 5.68% | ||
| 3 | FRANKLIN RESOURCES INC | 1,194,331 | 69,630,000 | 5.10% | ||
| 4 | LORD, ABBETT & CO. LLC | 1,095,283 | 63,855,000 | 4.67% | ||
| 5 | Visium Asset Management, LP | 1,075,309 | 62,690,000 | 4.59% | ||
| 6 | JPMORGAN CHASE & CO | 966,408 | 56,341,000 | 4.12% | ||
| 7 | Redmile Group, LLC | 958,374 | 55,873,000 | 4.09% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 864,370 | 50,392,000 | 3.69% | ||
| 9 | BB BIOTECH AG | 708,663 | 41,315,000 | 3.02% | ||
| 10 | BlackRock Fund Advisors | 672,519 | 39,208,000 | 2.87% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 917,882 | 38,845,000 | 2.84% | ||
| 12 | OAK RIDGE INVESTMENTS LLC | 651,420 | 37,977,000 | 2.78% | ||
| 13 | DEERFIELD MANAGEMENT COMPANY, L.P. | 598,854 | 34,913,000 | 2.56% | ||
| 14 | STATE STREET CORP | 531,935 | 31,011,000 | 2.27% | ||
| 15 | MILLENNIUM MANAGEMENT LLC | 518,738 | 30,242,000 | 2.21% | ||
| 16 | GILDER GAGNON HOWE & CO LLC | 512,080 | 29,854,000 | 2.19% | ||
| 17 | RS INVESTMENT MANAGEMENT CO LLC | 504,405 | 29,407,000 | 2.15% | ||
| 18 | PRICE T ROWE ASSOCIATES INC /MD/ | 381,525 | 22,243,000 | 1.63% | ||
| 19 | Cormorant Asset Management, LP | 315,000 | 18,365,000 | 1.34% | ||
| 20 | Bank of New York Mellon Corp | 310,827 | 18,122,000 | 1.33% | ||
| 21 | BlackRock Institutional Trust Company, N.A. | 277,513 | 16,179,000 | 1.18% | ||
| 22 | Granahan Investment Management, LLC | 274,885 | 16,026,000 | 1.17% | ||
| 23 | JENNISON ASSOCIATES LLC | 255,145 | 14,875,000 | 1.09% | ||
| 24 | CITADEL ADVISORS LLC | 239,673 | 13,973,000 | 1.02% | ||
| 25 | APEX CAPITAL, LLC | 225,000 | 13,118,000 | 0.96% | ||
| 26 | FEDERATED HERMES, INC. | 205,000 | 11,952,000 | 0.87% | ||
| 27 | Ghost Tree Capital, LLC | 200,000 | 11,660,000 | 0.85% | ||
| 28 | HIGHLAND CAPITAL MANAGEMENT LP | 152,985 | 8,919,000 | 0.65% | ||
| 29 | NORTHERN TRUST CORP | 151,685 | 8,843,000 | 0.65% | ||
| 30 | CASDIN CAPITAL, LLC | 143,011 | 8,338,000 | 0.61% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 125,900 | 7,340,000 | 0.54% | ||
| 32 | NORGES BANK | 120,566 | 7,029,000 | 0.51% | ||
| 33 | BLACKROCK ADVISORS LLC | 118,389 | 6,902,000 | 0.51% | ||
| 34 | OXFORD ASSET MANAGEMENT LLP | 115,936 | 6,751,000 | 0.49% | ||
| 35 | BAKER BROS. ADVISORS LP | 105,000 | 6,122,000 | 0.45% | ||
| 36 | HARBOURVEST PARTNERS LLC | 104,568 | 6,096,000 | 0.45% | ||
| 37 | Opaleye Management Inc. | 100,000 | 5,830,000 | 0.43% | ||
| 38 | GOLDMAN SACHS GROUP INC | 100,000 | 5,830,000 | 0.43% | Put | |
| 39 | Tekla Capital Management LLC | 97,800 | 5,702,000 | 0.42% | ||
| 40 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 92,991 | 5,422,000 | 0.40% | ||
| 41 | SPHERA FUNDS MANAGEMENT LTD. | 93,000 | 5,422,000 | 0.40% | ||
| 42 | GEODE CAPITAL MANAGEMENT, LLC | 80,650 | 4,701,000 | 0.34% | ||
| 43 | GAM Holding AG | 79,400 | 4,629,000 | 0.34% | ||
| 44 | AlpInvest Partners B.V. | 78,641 | 4,585,000 | 0.34% | ||
| 45 | Candriam S.C.A. | 76,200 | 4,442,000 | 0.33% | ||
| 46 | GUGGENHEIM CAPITAL LLC | 69,160 | 4,032,000 | 0.30% | ||
| 47 | BANK OF AMERICA CORP /DE/ | 62,729 | 3,657,000 | 0.27% | ||
| 48 | Nicholas Investment Partners, LP | 61,789 | 3,602,000 | 0.26% | ||
| 49 | HERSHEY TRUST CO | 58,940 | 3,436,000 | 0.25% | ||
| 50 | LAZARD ASSET MANAGEMENT LLC | 57,300 | 3,340,000 | 0.24% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
