| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 11,681,008 | 427,525,000 | 58.12% | ||
| 2 | FMR LLC | 3,868,893 | 141,601,000 | 19.25% | ||
| 3 | BlackRock Fund Advisors | 461,948 | 16,907,000 | 2.30% | ||
| 4 | ORBIMED ADVISORS LLC | 412,335 | 15,091,000 | 2.05% | ||
| 5 | RS INVESTMENT MANAGEMENT CO LLC | 354,058 | 12,959,000 | 1.76% | ||
| 6 | DEERFIELD MANAGEMENT COMPANY, L.P. | 262,625 | 9,612,000 | 1.31% | ||
| 7 | ALLIANCEBERNSTEIN L.P. | 249,666 | 9,138,000 | 1.24% | ||
| 8 | EcoR1 Capital, LLC | 491,044 | 9,069,000 | 1.23% | ||
| 9 | VANGUARD GROUP INC | 222,745 | 8,152,000 | 1.11% | ||
| 10 | FEDERATED HERMES, INC. | 204,200 | 7,474,000 | 1.02% | ||
| 11 | FRANKLIN RESOURCES INC | 200,000 | 7,320,000 | 1.00% | ||
| 12 | JPMORGAN CHASE & CO | 178,071 | 6,517,000 | 0.89% | ||
| 13 | STIFEL FINANCIAL CORP | 100,261 | 5,725,000 | 0.78% | ||
| 14 | Foresite Capital Management II, LLC | 144,569 | 5,291,000 | 0.72% | ||
| 15 | LORD, ABBETT & CO. LLC | 108,226 | 3,961,000 | 0.54% | ||
| 16 | SPHERA FUNDS MANAGEMENT LTD. | 79,724 | 2,918,000 | 0.40% | ||
| 17 | BAKER BROS. ADVISORS LP | 75,000 | 2,745,000 | 0.37% | ||
| 18 | STATE STREET CORP | 72,872 | 2,668,000 | 0.36% | ||
| 19 | PERCEPTIVE ADVISORS LLC | 70,484 | 2,580,000 | 0.35% | ||
| 20 | Nicholas Investment Partners, LP | 65,186 | 2,386,000 | 0.32% | ||
| 21 | Candriam S.C.A. | 65,000 | 2,379,000 | 0.32% | ||
| 22 | BLACKROCK ADVISORS LLC | 62,276 | 2,279,000 | 0.31% | ||
| 23 | NORTHERN TRUST CORP | 58,615 | 2,146,000 | 0.29% | ||
| 24 | BlackRock Institutional Trust Company, N.A. | 55,203 | 2,020,000 | 0.27% | ||
| 25 | CITADEL ADVISORS LLC | 54,462 | 1,993,000 | 0.27% | ||
| 26 | DRIEHAUS CAPITAL MANAGEMENT LLC | 53,864 | 1,971,000 | 0.27% | ||
| 27 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 49,300 | 1,804,000 | 0.25% | ||
| 28 | Numeric Investors LLC | 49,040 | 1,795,000 | 0.24% | ||
| 29 | Alyeska Investment Group, L.P. | 47,515 | 1,739,000 | 0.24% | ||
| 30 | EVENTIDE ASSET MANAGEMENT, LLC | 40,200 | 1,471,000 | 0.20% | ||
| 31 | Bank of New York Mellon Corp | 39,533 | 1,447,000 | 0.20% | ||
| 32 | New Leaf Venture Partners, L.L.C. | 35,370 | 1,295,000 | 0.18% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 34,786 | 1,273,000 | 0.17% | ||
| 34 | GOLDMAN SACHS GROUP INC | 34,054 | 1,246,000 | 0.17% | ||
| 35 | DENVER INVESTMENT ADVISORS LLC | 32,201 | 1,179,000 | 0.16% | ||
| 36 | Nationwide Fund Advisors | 24,138 | 883,000 | 0.12% | ||
| 37 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 21,121 | 844,000 | 0.11% | ||
| 38 | BlackRock Investment Management, LLC | 18,663 | 683,000 | 0.09% | ||
| 39 | BlackRock Group LTD | 18,562 | 679,000 | 0.09% | ||
| 40 | ProShare Advisors LLC | 18,312 | 670,000 | 0.09% | ||
| 41 | CITIGROUP INC | 17,656 | 647,000 | 0.09% | ||
| 42 | A.R.T. Advisors, LLC | 17,089 | 625,000 | 0.08% | ||
| 43 | Neuberger Berman Group LLC | 14,500 | 530,000 | 0.07% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 14,396 | 527,000 | 0.07% | ||
| 45 | DEUTSCHE BANK AG\ | 12,678 | 463,000 | 0.06% | ||
| 46 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 10,645 | 390,000 | 0.05% | ||
| 47 | CREDIT SUISSE AG/ | 10,485 | 383,000 | 0.05% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 8,000 | 293,000 | 0.04% | ||
| 49 | TEACHERS ADVISORS, LLC | 7,681 | 281,000 | 0.04% | ||
| 50 | BlackRock Finance, Inc. | 7,139 | 261,000 | 0.04% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
