| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 6,442,916 | 272,664,000 | 23.03% | ||
| 2 | FMR LLC | 4,321,989 | 182,907,000 | 15.45% | ||
| 3 | Redmile Group, LLC | 1,142,864 | 48,366,000 | 4.09% | ||
| 4 | VANGUARD GROUP INC | 1,132,661 | 47,935,000 | 4.05% | ||
| 5 | FRANKLIN RESOURCES INC | 1,032,310 | 43,687,000 | 3.69% | ||
| 6 | ALLIANCEBERNSTEIN L.P. | 914,285 | 38,693,000 | 3.27% | ||
| 7 | Visium Asset Management, LP | 902,948 | 38,213,000 | 3.23% | ||
| 8 | JPMORGAN CHASE & CO | 899,460 | 38,065,000 | 3.22% | ||
| 9 | GILDER GAGNON HOWE & CO LLC | 816,539 | 34,556,000 | 2.92% | ||
| 10 | EAGLE ASSET MANAGEMENT INC | 751,803 | 31,816,000 | 2.69% | ||
| 11 | BlackRock Fund Advisors | 738,434 | 31,251,000 | 2.64% | ||
| 12 | PRICE T ROWE ASSOCIATES INC /MD/ | 731,510 | 30,958,000 | 2.61% | ||
| 13 | OAK RIDGE INVESTMENTS LLC | 660,218 | 27,940,000 | 2.36% | ||
| 14 | DEERFIELD MANAGEMENT COMPANY, L.P. | 649,064 | 27,468,000 | 2.32% | ||
| 15 | STATE STREET CORP | 624,724 | 26,438,000 | 2.23% | ||
| 16 | ALPS ADVISORS INC | 44,401 | 18,791,000 | 1.59% | ||
| 17 | RS INVESTMENT MANAGEMENT CO LLC | 439,838 | 18,614,000 | 1.57% | ||
| 18 | APEX CAPITAL, LLC | 350,000 | 14,812,000 | 1.25% | ||
| 19 | Granahan Investment Management, LLC | 311,265 | 13,173,000 | 1.11% | ||
| 20 | BlackRock Institutional Trust Company, N.A. | 280,637 | 11,877,000 | 1.00% | ||
| 21 | LORD, ABBETT & CO. LLC | 260,368 | 11,019,000 | 0.93% | ||
| 22 | Cormorant Asset Management, LP | 240,000 | 10,157,000 | 0.86% | ||
| 23 | FEDERATED HERMES, INC. | 204,700 | 8,663,000 | 0.73% | ||
| 24 | HARBOURVEST PARTNERS LLC | 163,819 | 6,933,000 | 0.59% | ||
| 25 | HAMILTON LANE ADVISORS LLC | 159,303 | 6,742,000 | 0.57% | ||
| 26 | ORBIMED ADVISORS LLC | 149,999 | 6,348,000 | 0.54% | ||
| 27 | NORTHERN TRUST CORP | 145,271 | 6,148,000 | 0.52% | ||
| 28 | Allianz Asset Management GmbH | 138,145 | 5,846,000 | 0.49% | ||
| 29 | CITADEL ADVISORS LLC | 127,546 | 5,398,000 | 0.46% | ||
| 30 | BLACKROCK ADVISORS LLC | 121,656 | 5,148,000 | 0.43% | ||
| 31 | EVENTIDE ASSET MANAGEMENT, LLC | 119,200 | 5,045,000 | 0.43% | ||
| 32 | BAKER BROS. ADVISORS LP | 105,000 | 4,444,000 | 0.38% | ||
| 33 | GUGGENHEIM CAPITAL LLC | 104,163 | 4,408,000 | 0.37% | ||
| 34 | GOLDMAN SACHS GROUP INC | 98,800 | 4,181,000 | 0.35% | Call | |
| 35 | Tekla Capital Management LLC | 97,800 | 4,139,000 | 0.35% | ||
| 36 | AlpInvest Partners B.V. | 93,741 | 3,967,000 | 0.34% | ||
| 37 | Bank of New York Mellon Corp | 83,108 | 3,518,000 | 0.30% | ||
| 38 | Tekla Capital Management LLC | 82,800 | 3,504,000 | 0.30% | Call | |
| 39 | PICTON MAHONEY ASSET MANAGEMENT | 76,900 | 3,253,000 | 0.27% | SH | |
| 40 | GEODE CAPITAL MANAGEMENT, LLC | 75,337 | 3,188,000 | 0.27% | ||
| 41 | Nicholas Investment Partners, LP | 69,127 | 2,925,000 | 0.25% | ||
| 42 | Candriam S.C.A. | 66,200 | 2,802,000 | 0.24% | ||
| 43 | LAZARD ASSET MANAGEMENT LLC | 62,425 | 2,641,000 | 0.22% | ||
| 44 | NORGES BANK | 59,613 | 2,523,000 | 0.21% | ||
| 45 | TIAA CREF INVESTMENT MANAGEMENT LLC | 59,328 | 2,511,000 | 0.21% | ||
| 46 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 56,600 | 2,395,000 | 0.20% | Put | |
| 47 | BlackRock Investment Management, LLC | 53,671 | 2,271,000 | 0.19% | ||
| 48 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 52,087 | 2,204,000 | 0.19% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 50,073 | 2,119,000 | 0.18% | ||
| 50 | GAM Holding AG | 45,600 | 1,930,000 | 0.16% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
