| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 4,804,432 | 144,758,000 | 14.53% | ||
| 2 | VANGUARD GROUP INC | 1,742,561 | 52,503,000 | 5.27% | ||
| 3 | FRANKLIN RESOURCES INC | 1,417,977 | 42,724,000 | 4.29% | ||
| 4 | JPMORGAN CHASE & CO | 1,076,113 | 32,423,000 | 3.26% | ||
| 5 | ALLIANCEBERNSTEIN L.P. | 1,054,499 | 31,772,000 | 3.19% | ||
| 6 | BlackRock Fund Advisors | 1,037,928 | 31,273,000 | 3.14% | ||
| 7 | STATE STREET CORP | 929,473 | 28,002,000 | 2.81% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 873,924 | 26,331,000 | 2.64% | ||
| 9 | BB BIOTECH AG | 850,639 | 25,630,000 | 2.57% | ||
| 10 | OppenheimerFunds, Inc. | 770,157 | 23,205,000 | 2.33% | ||
| 11 | Cormorant Asset Management, LP | 730,000 | 21,995,000 | 2.21% | ||
| 12 | LORD, ABBETT & CO. LLC | 722,800 | 21,778,000 | 2.19% | ||
| 13 | MILLENNIUM MANAGEMENT LLC | 715,536 | 21,559,000 | 2.16% | ||
| 14 | MARSHALL WACE, LLP | 690,965 | 20,818,000 | 2.09% | ||
| 15 | CITADEL ADVISORS LLC | 650,008 | 19,585,000 | 1.97% | ||
| 16 | OAK RIDGE INVESTMENTS LLC | 639,301 | 19,262,000 | 1.93% | ||
| 17 | RS INVESTMENT MANAGEMENT CO LLC | 586,826 | 17,681,000 | 1.78% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 491,527 | 14,810,000 | 1.49% | ||
| 19 | Granahan Investment Management, LLC | 479,275 | 14,441,000 | 1.45% | ||
| 20 | PICTET ASSET MANAGEMENT LTD | 436,538 | 14,367,000 | 1.44% | ||
| 21 | PRICE T ROWE ASSOCIATES INC /MD/ | 471,070 | 14,193,000 | 1.43% | ||
| 22 | JENNISON ASSOCIATES LLC | 433,411 | 13,059,000 | 1.31% | ||
| 23 | Palo Alto Investors LP | 417,878 | 12,591,000 | 1.26% | ||
| 24 | DEUTSCHE BANK AG\ | 417,012 | 12,563,000 | 1.26% | ||
| 25 | Jefferies Group LLC | 413,500 | 12,459,000 | 1.25% | Put | |
| 26 | Jefferies Group LLC | 393,900 | 11,868,000 | 1.19% | Call | |
| 27 | VOYA INVESTMENT MANAGEMENT LLC | 359,813 | 10,841,000 | 1.09% | ||
| 28 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 331,056 | 9,974,000 | 1.00% | ||
| 29 | GREAT POINT PARTNERS LLC | 330,000 | 9,943,000 | 1.00% | ||
| 30 | GILDER GAGNON HOWE & CO LLC | 324,344 | 9,772,000 | 0.98% | ||
| 31 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 300,000 | 9,039,000 | 0.91% | Put | |
| 32 | FEDERATED HERMES, INC. | 295,000 | 8,888,000 | 0.89% | ||
| 33 | NORTHERN TRUST CORP | 283,797 | 8,550,000 | 0.86% | ||
| 34 | FOLGER HILL ASSET MANAGEMENT LP | 280,046 | 8,438,000 | 0.85% | ||
| 35 | MILLENNIUM MANAGEMENT LLC | 280,000 | 8,436,000 | 0.85% | Call | |
| 36 | EverPoint Asset Management, LLC | 250,000 | 7,533,000 | 0.76% | ||
| 37 | BLACKROCK ADVISORS LLC | 234,866 | 7,076,000 | 0.71% | ||
| 38 | BARCLAYS PLC | 231,000 | 6,960,000 | 0.70% | Put | |
| 39 | BARCLAYS PLC | 231,000 | 6,960,000 | 0.70% | Call | |
| 40 | CASDIN CAPITAL, LLC | 228,500 | 6,885,000 | 0.69% | ||
| 41 | BAKER BROS. ADVISORS LP | 224,048 | 6,751,000 | 0.68% | ||
| 42 | NORGES BANK | 193,861 | 5,841,000 | 0.59% | ||
| 43 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 190,100 | 5,728,000 | 0.58% | ||
| 44 | OXFORD ASSET MANAGEMENT LLP | 172,485 | 5,197,000 | 0.52% | ||
| 45 | EVENTIDE ASSET MANAGEMENT, LLC | 170,000 | 5,122,000 | 0.51% | ||
| 46 | J. Goldman & Co LP | 169,000 | 5,092,000 | 0.51% | Call | |
| 47 | Point72 Asset Management, L.P. | 167,700 | 5,053,000 | 0.51% | ||
| 48 | GAM Holding AG | 158,800 | 4,785,000 | 0.48% | ||
| 49 | New Leaf Venture Partners, L.L.C. | 156,958 | 4,729,000 | 0.47% | ||
| 50 | Ghost Tree Capital, LLC | 150,000 | 4,520,000 | 0.45% | Call |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
