| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,474,480 | 252,100,000 | 14.18% | ||
| 2 | VANGUARD GROUP INC | 2,296,767 | 105,767,000 | 5.95% | ||
| 3 | OppenheimerFunds, Inc. | 1,915,874 | 88,226,000 | 4.96% | ||
| 4 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,401,678 | 64,547,000 | 3.63% | ||
| 5 | CITADEL ADVISORS LLC | 1,274,413 | 58,687,000 | 3.30% | ||
| 6 | FEDERATED HERMES, INC. | 1,224,200 | 56,374,000 | 3.17% | ||
| 7 | FRANKLIN RESOURCES INC | 1,210,082 | 55,724,000 | 3.13% | ||
| 8 | JPMORGAN CHASE & CO | 1,206,544 | 55,562,000 | 3.13% | ||
| 9 | BlackRock Fund Advisors | 1,189,093 | 54,758,000 | 3.08% | ||
| 10 | STATE STREET CORP | 1,170,501 | 53,904,000 | 3.03% | ||
| 11 | OAK RIDGE INVESTMENTS LLC | 1,154,481 | 53,164,000 | 2.99% | ||
| 12 | DEUTSCHE BANK AG\ | 1,032,426 | 47,542,000 | 2.67% | ||
| 13 | BB BIOTECH AG | 1,022,439 | 47,083,000 | 2.65% | ||
| 14 | ALLIANCEBERNSTEIN L.P. | 945,582 | 43,544,000 | 2.45% | ||
| 15 | Palo Alto Investors LP | 902,051 | 41,539,000 | 2.34% | ||
| 16 | JENNISON ASSOCIATES LLC | 825,744 | 38,026,000 | 2.14% | ||
| 17 | MILLENNIUM MANAGEMENT LLC | 722,392 | 33,266,000 | 1.87% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 681,592 | 31,387,000 | 1.77% | ||
| 19 | LORD, ABBETT & CO. LLC | 679,048 | 31,270,000 | 1.76% | ||
| 20 | MARSHALL WACE, LLP | 673,539 | 31,017,000 | 1.74% | ||
| 21 | EAGLE ASSET MANAGEMENT INC | 630,494 | 29,034,000 | 1.63% | ||
| 22 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 506,990 | 23,347,000 | 1.31% | ||
| 23 | VICTORY CAPITAL MANAGEMENT INC | 501,558 | 23,097,000 | 1.30% | ||
| 24 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 390,406 | 17,978,000 | 1.01% | ||
| 25 | BLACKROCK ADVISORS LLC | 347,425 | 15,999,000 | 0.90% | ||
| 26 | PICTET ASSET MANAGEMENT LTD | 343,429 | 15,815,000 | 0.89% | ||
| 27 | Granahan Investment Management, LLC | 316,065 | 14,555,000 | 0.82% | ||
| 28 | GOLDMAN SACHS GROUP INC | 311,480 | 14,343,000 | 0.81% | ||
| 29 | NORTHERN TRUST CORP | 305,998 | 14,091,000 | 0.79% | ||
| 30 | VOYA INVESTMENT MANAGEMENT LLC | 267,938 | 12,338,000 | 0.69% | ||
| 31 | CASDIN CAPITAL, LLC | 266,500 | 12,272,000 | 0.69% | ||
| 32 | GREAT POINT PARTNERS LLC | 264,893 | 12,198,000 | 0.69% | ||
| 33 | EverPoint Asset Management, LLC | 250,000 | 11,513,000 | 0.65% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 245,000 | 11,282,000 | 0.63% | Put | |
| 35 | ORBIMED ADVISORS LLC | 235,400 | 10,840,000 | 0.61% | ||
| 36 | NORGES BANK | 243,861 | 10,726,000 | 0.60% | ||
| 37 | BALYASNY ASSET MANAGEMENT L.P. | 230,006 | 10,592,000 | 0.60% | ||
| 38 | FRONTIER CAPITAL MANAGEMENT CO LLC | 228,954 | 10,543,000 | 0.59% | ||
| 39 | GEODE CAPITAL MANAGEMENT, LLC | 225,761 | 10,396,000 | 0.58% | ||
| 40 | BAKER BROS. ADVISORS LP | 208,328 | 9,594,000 | 0.54% | ||
| 41 | Artal Group S.A. | 200,000 | 9,210,000 | 0.52% | ||
| 42 | UBS Group AG | 175,000 | 8,059,000 | 0.45% | Call | |
| 43 | Ghost Tree Capital, LLC | 175,000 | 8,059,000 | 0.45% | ||
| 44 | EVENTIDE ASSET MANAGEMENT, LLC | 170,000 | 7,829,000 | 0.44% | ||
| 45 | Point72 Asset Management, L.P. | 166,600 | 7,672,000 | 0.43% | ||
| 46 | SPHERA FUNDS MANAGEMENT LTD. | 159,500 | 7,345,000 | 0.41% | ||
| 47 | CLARIUS GROUP, LLC | 149,068 | 6,865,000 | 0.39% | ||
| 48 | Tekla Capital Management LLC | 146,800 | 6,760,000 | 0.38% | ||
| 49 | Bank of New York Mellon Corp | 137,267 | 6,321,000 | 0.36% | ||
| 50 | New Leaf Venture Partners, L.L.C. | 132,674 | 6,110,000 | 0.34% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
