| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 5,575,076 | 284,663,000 | 14.74% | ||
| 2 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,558,333 | 130,628,000 | 6.76% | ||
| 3 | VANGUARD GROUP INC | 2,429,516 | 124,052,000 | 6.42% | ||
| 4 | OppenheimerFunds, Inc. | 1,936,075 | 98,856,000 | 5.12% | ||
| 5 | BlackRock Fund Advisors | 1,420,226 | 72,517,000 | 3.75% | ||
| 6 | STATE STREET CORP | 1,157,665 | 59,107,000 | 3.06% | ||
| 7 | FRANKLIN RESOURCES INC | 1,121,403 | 57,259,000 | 2.96% | ||
| 8 | BB BIOTECH AG | 1,022,439 | 52,206,000 | 2.70% | ||
| 9 | OAK RIDGE INVESTMENTS LLC | 1,014,527 | 51,802,000 | 2.68% | ||
| 10 | Palo Alto Investors LP | 1,009,930 | 51,567,000 | 2.67% | ||
| 11 | JPMORGAN CHASE & CO | 998,787 | 50,999,000 | 2.64% | ||
| 12 | FEDERATED HERMES, INC. | 959,800 | 49,007,000 | 2.54% | ||
| 13 | ALLIANCEBERNSTEIN L.P. | 949,163 | 48,464,000 | 2.51% | ||
| 14 | DEUTSCHE BANK AG\ | 903,635 | 46,136,000 | 2.39% | ||
| 15 | JENNISON ASSOCIATES LLC | 828,475 | 42,302,000 | 2.19% | ||
| 16 | BlackRock Institutional Trust Company, N.A. | 782,105 | 39,934,000 | 2.07% | ||
| 17 | Bank of New York Mellon Corp | 711,066 | 36,307,000 | 1.88% | ||
| 18 | EAGLE ASSET MANAGEMENT INC | 671,806 | 34,302,000 | 1.78% | ||
| 19 | LORD, ABBETT & CO. LLC | 573,054 | 29,260,000 | 1.51% | ||
| 20 | VICTORY CAPITAL MANAGEMENT INC | 473,838 | 24,195,000 | 1.25% | ||
| 21 | GREAT POINT PARTNERS LLC | 385,683 | 19,693,000 | 1.02% | ||
| 22 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 382,249 | 19,518,000 | 1.01% | ||
| 23 | BALYASNY ASSET MANAGEMENT L.P. | 377,360 | 19,268,000 | 1.00% | ||
| 24 | BLACKROCK ADVISORS LLC | 371,543 | 18,971,000 | 0.98% | ||
| 25 | NORTHERN TRUST CORP | 341,534 | 17,439,000 | 0.90% | ||
| 26 | MARSHALL WACE, LLP | 310,087 | 15,833,000 | 0.82% | ||
| 27 | PICTET ASSET MANAGEMENT LTD | 293,542 | 14,988,000 | 0.78% | ||
| 28 | MILLENNIUM MANAGEMENT LLC | 276,127 | 14,099,000 | 0.73% | ||
| 29 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 274,339 | 14,008,000 | 0.73% | ||
| 30 | CASDIN CAPITAL, LLC | 259,500 | 13,250,000 | 0.69% | ||
| 31 | GEODE CAPITAL MANAGEMENT, LLC | 244,179 | 12,467,000 | 0.65% | ||
| 32 | NORGES BANK | 243,861 | 12,452,000 | 0.64% | ||
| 33 | CITIGROUP INC | 236,553 | 12,078,000 | 0.63% | ||
| 34 | BAKER BROS. ADVISORS LP | 208,328 | 10,637,000 | 0.55% | ||
| 35 | KINGDON CAPITAL MANAGEMENT, L.L.C. | 200,000 | 10,212,000 | 0.53% | Put | |
| 36 | Ghost Tree Capital, LLC | 200,000 | 10,212,000 | 0.53% | ||
| 37 | JANA PARTNERS LLC | 198,406 | 10,131,000 | 0.52% | ||
| 38 | J. Goldman & Co LP | 176,000 | 8,987,000 | 0.47% | Call | |
| 39 | EVENTIDE ASSET MANAGEMENT, LLC | 170,000 | 8,680,000 | 0.45% | ||
| 40 | VOYA INVESTMENT MANAGEMENT LLC | 160,630 | 8,201,000 | 0.42% | ||
| 41 | FOLGER HILL ASSET MANAGEMENT LP | 155,700 | 7,950,000 | 0.41% | Call | |
| 42 | CLARIUS GROUP, LLC | 149,068 | 7,911,000 | 0.41% | ||
| 43 | GOLDMAN SACHS GROUP INC | 153,927 | 7,859,000 | 0.41% | ||
| 44 | Invesco Ltd. | 150,309 | 7,675,000 | 0.40% | ||
| 45 | Artal Group S.A. | 150,000 | 7,659,000 | 0.40% | ||
| 46 | EverPoint Asset Management, LLC | 145,000 | 7,404,000 | 0.38% | ||
| 47 | BlackRock Investment Management, LLC | 130,472 | 6,662,000 | 0.34% | ||
| 48 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 129,847 | 6,630,000 | 0.34% | ||
| 49 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 128,300 | 6,551,000 | 0.34% | Call | |
| 50 | CREDIT SUISSE AG/ | 120,685 | 6,162,000 | 0.32% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
