| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 8,773,073 | 640,434,000 | 33.01% | ||
| 2 | FMR LLC | 4,264,489 | 311,308,000 | 16.05% | ||
| 3 | LORD, ABBETT & CO. LLC | 1,087,109 | 79,359,000 | 4.09% | ||
| 4 | GILDER GAGNON HOWE & CO LLC | 929,297 | 67,839,000 | 3.50% | ||
| 5 | VANGUARD GROUP INC | 860,189 | 62,795,000 | 3.24% | ||
| 6 | JPMORGAN CHASE & CO | 809,638 | 59,102,000 | 3.05% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 758,222 | 55,350,000 | 2.85% | ||
| 8 | BlackRock Fund Advisors | 694,471 | 50,696,000 | 2.61% | ||
| 9 | FRANKLIN RESOURCES INC | 685,410 | 50,035,000 | 2.58% | ||
| 10 | ALLIANCEBERNSTEIN L.P. | 685,039 | 50,008,000 | 2.58% | ||
| 11 | OAK RIDGE INVESTMENTS LLC | 660,895 | 48,245,000 | 2.49% | ||
| 12 | Visium Asset Management, LP | 656,921 | 47,955,000 | 2.47% | ||
| 13 | STATE STREET CORP | 481,815 | 35,177,000 | 1.81% | ||
| 14 | PRICE T ROWE ASSOCIATES INC /MD/ | 417,927 | 30,509,000 | 1.57% | ||
| 15 | RS INVESTMENT MANAGEMENT CO LLC | 380,478 | 27,775,000 | 1.43% | ||
| 16 | DEERFIELD MANAGEMENT COMPANY, L.P. | 305,000 | 22,265,000 | 1.15% | ||
| 17 | Redmile Group, LLC | 290,350 | 21,196,000 | 1.09% | ||
| 18 | Granahan Investment Management, LLC | 274,665 | 20,051,000 | 1.03% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 211,862 | 15,466,000 | 0.80% | ||
| 20 | FEDERATED HERMES, INC. | 204,200 | 14,907,000 | 0.77% | ||
| 21 | APEX CAPITAL, LLC | 180,000 | 13,140,000 | 0.68% | ||
| 22 | BLACKROCK ADVISORS LLC | 177,600 | 12,965,000 | 0.67% | ||
| 23 | ORBIMED ADVISORS LLC | 150,000 | 10,950,000 | 0.56% | ||
| 24 | HAMILTON LANE ADVISORS LLC | 106,039 | 7,741,000 | 0.40% | ||
| 25 | BAKER BROS. ADVISORS LP | 105,000 | 7,665,000 | 0.40% | ||
| 26 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 89,400 | 6,526,000 | 0.34% | Put | |
| 27 | Bank of New York Mellon Corp | 88,965 | 6,495,000 | 0.33% | ||
| 28 | NORTHERN TRUST CORP | 81,343 | 5,939,000 | 0.31% | ||
| 29 | DRIEHAUS CAPITAL MANAGEMENT LLC | 80,055 | 5,844,000 | 0.30% | ||
| 30 | GEODE CAPITAL MANAGEMENT, LLC | 72,892 | 5,321,000 | 0.27% | ||
| 31 | Candriam S.C.A. | 72,000 | 5,256,000 | 0.27% | ||
| 32 | PALISADE CAPITAL MANAGEMENT, LP | 71,004 | 5,183,000 | 0.27% | ||
| 33 | AlpInvest Partners B.V. | 63,741 | 4,653,000 | 0.24% | ||
| 34 | LAZARD ASSET MANAGEMENT LLC | 63,700 | 4,650,000 | 0.24% | ||
| 35 | Informed Momentum Co LLC | 62,313 | 4,549,000 | 0.23% | ||
| 36 | HARBOURVEST PARTNERS LLC | 61,180 | 4,466,000 | 0.23% | ||
| 37 | BlackRock Investment Management, LLC | 57,631 | 4,207,000 | 0.22% | ||
| 38 | Ghost Tree Capital, LLC | 57,500 | 4,198,000 | 0.22% | ||
| 39 | Nicholas Investment Partners, LP | 56,752 | 4,143,000 | 0.21% | ||
| 40 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 55,379 | 4,043,000 | 0.21% | ||
| 41 | Allianz Asset Management GmbH | 54,425 | 3,973,000 | 0.20% | ||
| 42 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 51,171 | 3,736,000 | 0.19% | ||
| 43 | SPHERA FUNDS MANAGEMENT LTD. | 48,000 | 3,504,000 | 0.18% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 44,545 | 3,252,000 | 0.17% | ||
| 45 | CREDIT SUISSE AG/ | 42,594 | 3,109,000 | 0.16% | ||
| 46 | EVENTIDE ASSET MANAGEMENT, LLC | 40,200 | 2,935,000 | 0.15% | ||
| 47 | MANAGED ACCOUNT ADVISORS LLC | 39,718 | 2,900,000 | 0.15% | ||
| 48 | TWO SIGMA INVESTMENTS, LP | 38,186 | 2,788,000 | 0.14% | ||
| 49 | AMERIPRISE FINANCIAL INC | 37,728 | 2,754,000 | 0.14% | ||
| 50 | PICTON MAHONEY ASSET MANAGEMENT | 37,500 | 2,738,000 | 0.14% | SH |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
