| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Third Rock Ventures, LLC | 9,773,073 | 490,901,000 | 45.41% | ||
| 2 | FMR LLC | 3,871,303 | 194,456,000 | 17.99% | ||
| 3 | JPMORGAN CHASE & CO | 794,792 | 39,923,000 | 3.69% | ||
| 4 | VANGUARD GROUP INC | 622,943 | 31,290,000 | 2.89% | ||
| 5 | DEERFIELD MANAGEMENT COMPANY, L.P. | 595,443 | 29,909,000 | 2.77% | ||
| 6 | FRANKLIN RESOURCES INC | 587,500 | 29,510,000 | 2.73% | ||
| 7 | BlackRock Fund Advisors | 481,540 | 24,188,000 | 2.24% | ||
| 8 | ORBIMED ADVISORS LLC | 412,335 | 20,712,000 | 1.92% | ||
| 9 | OAK RIDGE INVESTMENTS LLC | 385,770 | 19,377,000 | 1.79% | ||
| 10 | RS INVESTMENT MANAGEMENT CO LLC | 357,078 | 17,936,000 | 1.66% | ||
| 11 | ALLIANCEBERNSTEIN L.P. | 306,997 | 15,420,000 | 1.43% | ||
| 12 | BLACKROCK ADVISORS LLC | 288,917 | 14,512,000 | 1.34% | ||
| 13 | FEDERATED HERMES, INC. | 204,200 | 10,257,000 | 0.95% | ||
| 14 | APEX CAPITAL, LLC | 190,000 | 9,544,000 | 0.88% | ||
| 15 | LORD, ABBETT & CO. LLC | 179,897 | 9,036,000 | 0.84% | ||
| 16 | STIFEL FINANCIAL CORP | 158,036 | 7,939,000 | 0.73% | ||
| 17 | Granahan Investment Management, LLC | 149,156 | 7,492,000 | 0.69% | ||
| 18 | MILLENNIUM MANAGEMENT LLC | 147,640 | 7,416,000 | 0.69% | ||
| 19 | Ghost Tree Capital, LLC | 120,000 | 6,028,000 | 0.56% | ||
| 20 | DRIEHAUS CAPITAL MANAGEMENT LLC | 112,599 | 5,656,000 | 0.52% | ||
| 21 | EcoR1 Capital, LLC | 112,455 | 5,649,000 | 0.52% | ||
| 22 | PointState Capital LP | 102,450 | 5,146,000 | 0.48% | ||
| 23 | Lombard Odier Asset Management (USA) Corp | 92,089 | 4,626,000 | 0.43% | ||
| 24 | PRICE T ROWE ASSOCIATES INC /MD/ | 89,878 | 4,515,000 | 0.42% | ||
| 25 | Candriam S.C.A. | 79,000 | 3,969,000 | 0.37% | ||
| 26 | BAKER BROS. ADVISORS LP | 75,000 | 3,767,000 | 0.35% | ||
| 27 | STATE STREET CORP | 74,944 | 3,761,000 | 0.35% | ||
| 28 | PALISADE CAPITAL MANAGEMENT, LP | 72,797 | 3,657,000 | 0.34% | ||
| 29 | BlackRock Institutional Trust Company, N.A. | 72,583 | 3,646,000 | 0.34% | ||
| 30 | PERCEPTIVE ADVISORS LLC | 70,484 | 3,540,000 | 0.33% | ||
| 31 | SPHERA FUNDS MANAGEMENT LTD. | 65,724 | 3,301,000 | 0.31% | ||
| 32 | NORTHERN TRUST CORP | 61,594 | 3,093,000 | 0.29% | ||
| 33 | DENVER INVESTMENT ADVISORS LLC | 61,141 | 3,071,000 | 0.28% | ||
| 34 | Nicholas Investment Partners, LP | 56,246 | 2,825,000 | 0.26% | ||
| 35 | UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 48,100 | 2,416,000 | 0.22% | ||
| 36 | New Leaf Venture Partners, L.L.C. | 43,770 | 2,199,000 | 0.20% | ||
| 37 | EVENTIDE ASSET MANAGEMENT, LLC | 40,200 | 2,019,000 | 0.19% | ||
| 38 | GEODE CAPITAL MANAGEMENT, LLC | 37,728 | 1,895,000 | 0.18% | ||
| 39 | Bank of New York Mellon Corp | 37,612 | 1,890,000 | 0.17% | ||
| 40 | Trexquant Investment LP | 25,815 | 1,296,000 | 0.12% | ||
| 41 | TFS CAPITAL LLC | 25,069 | 1,259,000 | 0.12% | ||
| 42 | Nationwide Fund Advisors | 25,041 | 1,258,000 | 0.12% | ||
| 43 | Visium Asset Management, LP | 25,000 | 1,256,000 | 0.12% | ||
| 44 | DEUTSCHE BANK AG\ | 22,073 | 1,108,000 | 0.10% | ||
| 45 | ProShare Advisors LLC | 21,756 | 1,093,000 | 0.10% | ||
| 46 | CREDIT SUISSE AG/ | 20,784 | 1,044,000 | 0.10% | ||
| 47 | BlackRock Investment Management, LLC | 19,110 | 960,000 | 0.09% | ||
| 48 | UNITED SERVICES AUTOMOBILE ASSOCIATION | 17,456 | 877,000 | 0.08% | ||
| 49 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 21,121 | 844,000 | 0.08% | ||
| 50 | TOCQUEVILLE ASSET MANAGEMENT L.P. | 16,375 | 823,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
