| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Omega Fund Management, LLC | 2,600,410 | 62,670,000 | 10.94% | ||
| 2 | BAUPOST GROUP LLC/MA | 2,394,498 | 57,707,000 | 10.07% | ||
| 3 | BlackRock Finance, Inc. | 1,892,447 | 45,608,000 | 7.96% | ||
| 4 | FMR LLC | 1,461,592 | 35,224,000 | 6.15% | ||
| 5 | Abingworth LLP | 1,300,432 | 31,275,000 | 5.46% | ||
| 6 | VANGUARD GROUP INC | 867,616 | 20,909,000 | 3.65% | ||
| 7 | STATE STREET CORP | 616,112 | 14,850,000 | 2.59% | ||
| 8 | Rock Springs Capital Management LP | 600,000 | 14,460,000 | 2.52% | ||
| 9 | RENAISSANCE TECHNOLOGIES LLC | 596,749 | 14,382,000 | 2.51% | ||
| 10 | Tekla Capital Management LLC | 533,000 | 12,845,000 | 2.24% | ||
| 11 | INTERWEST VENTURE MANAGEMENT CO | 512,366 | 12,348,000 | 2.16% | ||
| 12 | FRANKLIN RESOURCES INC | 508,066 | 12,244,000 | 2.14% | ||
| 13 | Aisling Capital LLC | 482,680 | 11,633,000 | 2.03% | ||
| 14 | C WorldWide Group Holding A/S | 439,400 | 10,590,000 | 1.85% | ||
| 15 | Fortress Investment Group LLC | 433,804 | 10,454,000 | 1.82% | ||
| 16 | DEUTSCHE BANK AG\ | 422,273 | 10,175,000 | 1.78% | ||
| 17 | BROWN BROTHERS HARRIMAN & CO | 367,902 | 8,866,000 | 1.55% | ||
| 18 | BALYASNY ASSET MANAGEMENT L.P. | 350,000 | 8,435,000 | 1.47% | ||
| 19 | Invesco Ltd. | 344,399 | 8,300,000 | 1.45% | ||
| 20 | NORTHERN TRUST CORP | 329,693 | 7,946,000 | 1.39% | ||
| 21 | NORGES BANK | 314,654 | 7,583,000 | 1.32% | ||
| 22 | GENERAL AMERICAN INVESTORS CO INC | 307,213 | 7,404,000 | 1.29% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 346,985 | 6,957,000 | 1.21% | ||
| 24 | ROYCE & ASSOCIATES LP | 282,900 | 6,818,000 | 1.19% | ||
| 25 | Broadfin Capital, LLC | 277,020 | 6,676,000 | 1.17% | ||
| 26 | Numeric Investors LLC | 267,600 | 6,449,000 | 1.13% | ||
| 27 | ADAGE CAPITAL PARTNERS GP, L.L.C. | 263,860 | 6,359,000 | 1.11% | ||
| 28 | Roumell Asset Management, LLC | 257,748 | 6,214,000 | 1.08% | ||
| 29 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 234,900 | 5,661,000 | 0.99% | Call | |
| 30 | Candriam S.C.A. | 227,000 | 5,471,000 | 0.95% | ||
| 31 | Nicholas Investment Partners, LP | 204,009 | 4,916,000 | 0.86% | ||
| 32 | JPMORGAN CHASE & CO | 199,725 | 4,813,000 | 0.84% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 189,447 | 4,565,000 | 0.80% | ||
| 34 | Bank of New York Mellon Corp | 172,499 | 4,157,000 | 0.73% | ||
| 35 | Alyeska Investment Group, L.P. | 159,814 | 3,852,000 | 0.67% | ||
| 36 | SCHONFELD STRATEGIC ADVISORS LLC | 145,000 | 3,495,000 | 0.61% | ||
| 37 | Informed Momentum Co LLC | 144,022 | 3,471,000 | 0.61% | ||
| 38 | MORGAN STANLEY | 140,923 | 3,396,000 | 0.59% | ||
| 39 | DRIEHAUS CAPITAL MANAGEMENT LLC | 137,228 | 3,307,000 | 0.58% | ||
| 40 | Boston Partners | 133,682 | 3,222,000 | 0.56% | ||
| 41 | GOLDMAN SACHS GROUP INC | 131,723 | 3,175,000 | 0.55% | ||
| 42 | TIAA CREF INVESTMENT MANAGEMENT LLC | 93,047 | 2,242,000 | 0.39% | ||
| 43 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 91,800 | 2,212,000 | 0.39% | Put | |
| 44 | RAINIER INVESTMENT MANAGEMENT LLC | 85,790 | 2,068,000 | 0.36% | ||
| 45 | PARAMETRIC PORTFOLIO ASSOCIATES LLC | 72,493 | 1,747,000 | 0.30% | ||
| 46 | Crestline Management, LP | 71,799 | 1,730,000 | 0.30% | ||
| 47 | NEA Management Company, LLC | 66,245 | 1,597,000 | 0.28% | ||
| 48 | AXIOM INVESTORS LLC /DE | 63,882 | 1,540,000 | 0.27% | ||
| 49 | RUSSELL INVESTMENTS GROUP, LTD. | 63,787 | 1,538,000 | 0.27% | ||
| 50 | Allianz Asset Management GmbH | 61,647 | 1,486,000 | 0.26% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
