| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 6,896,819 | 291,804,000 | 24.61% | ||
| 2 | FMR LLC | 4,935,223 | 208,809,000 | 17.61% | ||
| 3 | SV Health Investors, LLC | 3,308,695 | 139,991,000 | 11.81% | ||
| 4 | JHL Capital Group LLC | 2,730,000 | 115,506,000 | 9.74% | ||
| 5 | Clarus Ventures, LLC | 1,554,744 | 65,781,000 | 5.55% | ||
| 6 | EAGLE ASSET MANAGEMENT INC | 1,356,103 | 57,376,000 | 4.84% | ||
| 7 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,192,547 | 50,457,000 | 4.26% | ||
| 8 | VANGUARD GROUP INC | 879,391 | 37,207,000 | 3.14% | ||
| 9 | RA CAPITAL MANAGEMENT, L.P. | 527,941 | 22,337,000 | 1.88% | ||
| 10 | STATE STREET CORP | 503,093 | 21,289,000 | 1.80% | ||
| 11 | MORGAN STANLEY | 387,360 | 16,390,000 | 1.38% | ||
| 12 | PERCEPTIVE ADVISORS LLC | 371,469 | 15,717,000 | 1.33% | ||
| 13 | BlackRock Fund Advisors | 306,044 | 12,949,000 | 1.09% | ||
| 14 | GREAT POINT PARTNERS LLC | 250,100 | 10,582,000 | 0.89% | ||
| 15 | GOLDMAN SACHS GROUP INC | 237,620 | 10,054,000 | 0.85% | ||
| 16 | Allianz Asset Management GmbH | 206,715 | 8,746,000 | 0.74% | ||
| 17 | BlackRock Institutional Trust Company, N.A. | 158,919 | 6,724,000 | 0.57% | ||
| 18 | FORT WASHINGTON INVESTMENT ADVISORS INC /OH/ | 133,329 | 5,641,000 | 0.48% | ||
| 19 | BARCLAYS PLC | 132,222 | 5,553,000 | 0.47% | ||
| 20 | NORTHERN TRUST CORP | 124,069 | 5,249,000 | 0.44% | ||
| 21 | HAMILTON LANE ADVISORS LLC | 92,372 | 3,908,000 | 0.33% | ||
| 22 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 88,468 | 3,743,000 | 0.32% | ||
| 23 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 86,900 | 3,677,000 | 0.31% | Put | |
| 24 | Bank of New York Mellon Corp | 82,226 | 3,478,000 | 0.29% | ||
| 25 | AlpInvest Partners B.V. | 82,046 | 3,471,000 | 0.29% | ||
| 26 | STATE OF MICHIGAN RETIREMENT SYSTEM | 82,046 | 3,471,000 | 0.29% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 77,296 | 3,270,000 | 0.28% | ||
| 28 | CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 72,062 | 3,049,000 | 0.26% | ||
| 29 | MANAGED ACCOUNT ADVISORS LLC | 70,738 | 2,993,000 | 0.25% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 53,112 | 2,247,000 | 0.19% | ||
| 31 | TCW GROUP INC | 49,307 | 2,086,000 | 0.18% | ||
| 32 | Cupps Capital Management, LLC | 48,355 | 2,045,000 | 0.17% | ||
| 33 | MILLENNIUM MANAGEMENT LLC | 44,358 | 1,877,000 | 0.16% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 40,900 | 1,730,000 | 0.15% | Call | |
| 35 | BlackRock Investment Management, LLC | 37,922 | 1,604,000 | 0.14% | ||
| 36 | BAKER BROS. ADVISORS LP | 36,776 | 1,556,000 | 0.13% | ||
| 37 | ALLIANCEBERNSTEIN L.P. | 33,300 | 1,409,000 | 0.12% | ||
| 38 | CAISSE DE DEPOT ET PLACEMENT DU QUEBEC | 32,818 | 1,389,000 | 0.12% | ||
| 39 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 32,220 | 1,363,000 | 0.11% | ||
| 40 | Informed Momentum Co LLC | 31,932 | 1,351,000 | 0.11% | ||
| 41 | Paloma Partners Management Co | 30,000 | 1,269,000 | 0.11% | ||
| 42 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,053 | 1,230,000 | 0.10% | ||
| 43 | GUGGENHEIM CAPITAL LLC | 29,028 | 1,228,000 | 0.10% | ||
| 44 | CREDIT SUISSE AG/ | 28,498 | 1,206,000 | 0.10% | ||
| 45 | AMERIPRISE FINANCIAL INC | 27,710 | 1,172,000 | 0.10% | ||
| 46 | WELLS FARGO & COMPANY/MN | 27,027 | 1,144,000 | 0.10% | ||
| 47 | Lisanti Capital Growth, LLC | 26,835 | 1,135,000 | 0.10% | ||
| 48 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,300 | 1,070,000 | 0.09% | ||
| 49 | Zweig-DiMenna Associates LLC | 25,000 | 1,058,000 | 0.09% | ||
| 50 | Airain ltd | 22,668 | 959,000 | 0.08% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
