| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 5,901,819 | 264,815,000 | 19.41% | ||
| 2 | FMR LLC | 5,047,672 | 226,489,000 | 16.60% | ||
| 3 | JHL Capital Group LLC | 3,265,000 | 146,501,000 | 10.74% | ||
| 4 | SV Health Investors, LLC | 2,621,575 | 117,630,000 | 8.62% | ||
| 5 | Clarus Ventures, LLC | 1,554,744 | 69,761,000 | 5.11% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,370,042 | 61,474,000 | 4.51% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,352,663 | 60,693,000 | 4.45% | ||
| 8 | VANGUARD GROUP INC | 1,224,708 | 54,952,000 | 4.03% | ||
| 9 | ORBIMED ADVISORS LLC | 861,800 | 38,669,000 | 2.83% | ||
| 10 | MORGAN STANLEY | 787,845 | 35,349,000 | 2.59% | ||
| 11 | BlackRock Fund Advisors | 744,865 | 33,422,000 | 2.45% | ||
| 12 | STATE STREET CORP | 550,842 | 24,713,000 | 1.81% | ||
| 13 | PERCEPTIVE ADVISORS LLC | 429,386 | 19,267,000 | 1.41% | ||
| 14 | Allianz Asset Management GmbH | 330,160 | 14,814,000 | 1.09% | ||
| 15 | RA CAPITAL MANAGEMENT, L.P. | 310,554 | 13,935,000 | 1.02% | ||
| 16 | STIFEL FINANCIAL CORP | 183,828 | 12,836,000 | 0.94% | ||
| 17 | GOLDMAN SACHS GROUP INC | 269,869 | 12,109,000 | 0.89% | ||
| 18 | BlackRock Institutional Trust Company, N.A. | 144,682 | 6,492,000 | 0.48% | ||
| 19 | NORTHERN TRUST CORP | 142,350 | 6,387,000 | 0.47% | ||
| 20 | Candriam S.C.A. | 136,000 | 6,102,000 | 0.45% | ||
| 21 | Cupps Capital Management, LLC | 126,781 | 5,688,000 | 0.42% | ||
| 22 | MILLENNIUM MANAGEMENT LLC | 107,663 | 4,831,000 | 0.35% | ||
| 23 | Opaleye Management Inc. | 100,000 | 4,487,000 | 0.33% | ||
| 24 | Bank of New York Mellon Corp | 99,167 | 4,450,000 | 0.33% | ||
| 25 | Apex Capital Management | 96,875 | 4,347,000 | 0.32% | ||
| 26 | BARCLAYS PLC | 98,335 | 4,327,000 | 0.32% | ||
| 27 | TIAA CREF INVESTMENT MANAGEMENT LLC | 95,962 | 4,306,000 | 0.32% | ||
| 28 | MANAGED ACCOUNT ADVISORS LLC | 95,494 | 4,285,000 | 0.31% | ||
| 29 | Cheyne Capital Management (UK) LLP | 91,487 | 4,105,000 | 0.30% | ||
| 30 | AMERICAN CENTURY COMPANIES INC | 90,646 | 4,067,000 | 0.30% | ||
| 31 | AXA S.A. | 89,001 | 3,993,000 | 0.29% | ||
| 32 | GEODE CAPITAL MANAGEMENT, LLC | 81,999 | 3,679,000 | 0.27% | ||
| 33 | Invesco Ltd. | 81,817 | 3,671,000 | 0.27% | ||
| 34 | Hillview Capital Advisors, LLC | 79,830 | 3,582,000 | 0.26% | ||
| 35 | MARSHALL WACE, LLP | 68,470 | 3,072,000 | 0.23% | ||
| 36 | FRANKLIN RESOURCES INC | 66,812 | 2,998,000 | 0.22% | ||
| 37 | AlpInvest Partners B.V. | 65,636 | 2,945,000 | 0.22% | ||
| 38 | Ghost Tree Capital, LLC | 65,000 | 2,917,000 | 0.21% | ||
| 39 | IMA Advisory Services, Inc. | 64,990 | 2,916,000 | 0.21% | ||
| 40 | WELLINGTON MANAGEMENT GROUP LLP | 59,468 | 2,669,000 | 0.20% | ||
| 41 | Informed Momentum Co LLC | 58,115 | 2,608,000 | 0.19% | ||
| 42 | ALLIANCEBERNSTEIN L.P. | 53,580 | 2,404,000 | 0.18% | ||
| 43 | TCW GROUP INC | 50,192 | 2,252,000 | 0.17% | ||
| 44 | GOLDMAN SACHS GROUP INC | 40,000 | 1,795,000 | 0.13% | Put | |
| 45 | BLACKROCK ADVISORS LLC | 39,603 | 1,777,000 | 0.13% | ||
| 46 | CREDIT SUISSE AG/ | 38,729 | 1,738,000 | 0.13% | ||
| 47 | BlackRock Investment Management, LLC | 37,491 | 1,682,000 | 0.12% | ||
| 48 | BAKER BROS. ADVISORS LP | 36,776 | 1,650,000 | 0.12% | ||
| 49 | ROYAL BANK OF CANADA | 33,215 | 1,490,000 | 0.11% | ||
| 50 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 32,220 | 1,446,000 | 0.11% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
