| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,696,385 | 188,627,000 | 10.88% | ||
| 2 | Novo Holdings A/S | 3,610,487 | 184,243,000 | 10.62% | ||
| 3 | JHL Capital Group LLC | 3,265,000 | 166,613,000 | 9.61% | ||
| 4 | VANGUARD GROUP INC | 2,211,545 | 112,855,000 | 6.51% | ||
| 5 | ORBIMED ADVISORS LLC | 2,148,100 | 109,618,000 | 6.32% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,767,562 | 90,199,000 | 5.20% | ||
| 7 | BlackRock Fund Advisors | 1,188,968 | 60,673,000 | 3.50% | ||
| 8 | EAGLE ASSET MANAGEMENT INC | 917,869 | 46,838,000 | 2.70% | ||
| 9 | STATE STREET CORP | 861,547 | 43,962,000 | 2.53% | ||
| 10 | MORGAN STANLEY | 859,561 | 43,863,000 | 2.53% | ||
| 11 | FRANKLIN RESOURCES INC | 805,929 | 41,126,000 | 2.37% | ||
| 12 | MILLENNIUM MANAGEMENT LLC | 804,294 | 41,043,000 | 2.37% | ||
| 13 | Fiera Capital Corp | 742,500 | 37,890,000 | 2.18% | ||
| 14 | BlackRock Institutional Trust Company, N.A. | 715,785 | 36,527,000 | 2.11% | ||
| 15 | Slate Path Capital LP | 430,000 | 21,943,000 | 1.27% | ||
| 16 | JANUS HENDERSON INVESTORS US LLC | 425,366 | 21,706,000 | 1.25% | ||
| 17 | Allianz Asset Management GmbH | 356,267 | 18,180,000 | 1.05% | ||
| 18 | WELLS FARGO & COMPANY/MN | 352,419 | 17,983,000 | 1.04% | ||
| 19 | THREE BAYS CAPITAL LP | 350,594 | 17,891,000 | 1.03% | ||
| 20 | Senator Investment Group LP | 350,500 | 17,886,000 | 1.03% | ||
| 21 | NORTHERN TRUST CORP | 336,435 | 17,168,000 | 0.99% | ||
| 22 | WELLINGTON MANAGEMENT GROUP LLP | 336,066 | 17,149,000 | 0.99% | ||
| 23 | PICTET ASSET MANAGEMENT LTD | 294,470 | 15,813,000 | 0.91% | ||
| 24 | LOOMIS SAYLES & CO L P | 290,108 | 14,804,000 | 0.85% | ||
| 25 | EATON VANCE MANAGEMENT | 286,600 | 14,625,000 | 0.84% | ||
| 26 | GOLDMAN SACHS GROUP INC | 277,593 | 14,165,000 | 0.82% | ||
| 27 | BANK OF AMERICA CORP /DE/ | 234,439 | 11,964,000 | 0.69% | ||
| 28 | GEODE CAPITAL MANAGEMENT, LLC | 224,462 | 11,454,000 | 0.66% | ||
| 29 | VOYA INVESTMENT MANAGEMENT LLC | 217,443 | 11,096,000 | 0.64% | ||
| 30 | Ghost Tree Capital, LLC | 215,000 | 10,971,000 | 0.63% | ||
| 31 | NORGES BANK | 199,872 | 10,199,000 | 0.59% | ||
| 32 | Broadfin Capital, LLC | 177,400 | 9,053,000 | 0.52% | ||
| 33 | AXA S.A. | 173,811 | 8,870,000 | 0.51% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 172,900 | 8,823,000 | 0.51% | Put | |
| 35 | Bank of New York Mellon Corp | 169,263 | 8,638,000 | 0.50% | ||
| 36 | SECTORAL ASSET MANAGEMENT INC | 146,800 | 7,491,000 | 0.43% | ||
| 37 | Rock Springs Capital Management LP | 142,500 | 7,272,000 | 0.42% | ||
| 38 | TIAA CREF INVESTMENT MANAGEMENT LLC | 141,025 | 7,197,000 | 0.41% | ||
| 39 | Cannell & Co. | 127,700 | 6,517,000 | 0.38% | ||
| 40 | MARSHALL WACE, LLP | 117,872 | 6,015,000 | 0.35% | ||
| 41 | BlackRock Investment Management, LLC | 113,775 | 5,806,000 | 0.33% | ||
| 42 | Pier Capital, LLC | 110,679 | 5,648,000 | 0.33% | ||
| 43 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 103,009 | 5,257,000 | 0.30% | ||
| 44 | DEUTSCHE BANK AG\ | 94,893 | 4,839,000 | 0.28% | ||
| 45 | JPMORGAN CHASE & CO | 92,581 | 4,724,000 | 0.27% | ||
| 46 | NEW YORK STATE COMMON RETIREMENT FUND | 92,236 | 4,707,000 | 0.27% | ||
| 47 | BNP Paribas Asset Management Holding S.A. | 86,492 | 4,414,000 | 0.25% | ||
| 48 | Candriam S.C.A. | 82,000 | 4,185,000 | 0.24% | ||
| 49 | Invesco Ltd. | 80,277 | 4,097,000 | 0.24% | ||
| 50 | Overbrook Management Corp | 75,652 | 3,861,000 | 0.22% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
