| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | Novo Holdings A/S | 6,896,819 | 268,493,000 | 23.57% | ||
| 2 | FMR LLC | 4,935,223 | 192,128,000 | 16.86% | ||
| 3 | SV Health Investors, LLC | 3,308,695 | 128,807,000 | 11.31% | ||
| 4 | JHL Capital Group LLC | 3,070,000 | 119,515,000 | 10.49% | ||
| 5 | Clarus Ventures, LLC | 1,554,744 | 60,526,000 | 5.31% | ||
| 6 | PRICE T ROWE ASSOCIATES INC /MD/ | 1,368,374 | 53,271,000 | 4.68% | ||
| 7 | EAGLE ASSET MANAGEMENT INC | 1,354,223 | 52,719,000 | 4.63% | ||
| 8 | VANGUARD GROUP INC | 956,656 | 37,243,000 | 3.27% | ||
| 9 | RA CAPITAL MANAGEMENT, L.P. | 588,941 | 22,927,000 | 2.01% | ||
| 10 | STATE STREET CORP | 587,243 | 22,864,000 | 2.01% | ||
| 11 | PERCEPTIVE ADVISORS LLC | 520,165 | 20,250,000 | 1.78% | ||
| 12 | MORGAN STANLEY | 423,511 | 16,487,000 | 1.45% | ||
| 13 | ORBIMED ADVISORS LLC | 338,800 | 13,189,000 | 1.16% | ||
| 14 | GREAT POINT PARTNERS LLC | 300,000 | 11,679,000 | 1.03% | ||
| 15 | BlackRock Fund Advisors | 299,497 | 11,659,000 | 1.02% | ||
| 16 | GOLDMAN SACHS GROUP INC | 235,167 | 9,155,000 | 0.80% | ||
| 17 | Allianz Asset Management GmbH | 218,955 | 8,524,000 | 0.75% | ||
| 18 | NORTHERN TRUST CORP | 147,220 | 5,732,000 | 0.50% | ||
| 19 | BlackRock Institutional Trust Company, N.A. | 146,623 | 5,708,000 | 0.50% | ||
| 20 | BARCLAYS PLC | 124,394 | 4,726,000 | 0.41% | ||
| 21 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 94,500 | 3,680,000 | 0.32% | Call | |
| 22 | MANAGED ACCOUNT ADVISORS LLC | 94,440 | 3,677,000 | 0.32% | ||
| 23 | Bank of New York Mellon Corp | 90,974 | 3,541,000 | 0.31% | ||
| 24 | GUGGENHEIM CAPITAL LLC | 83,715 | 3,259,000 | 0.29% | ||
| 25 | AXA S.A. | 83,306 | 3,243,000 | 0.28% | ||
| 26 | AlpInvest Partners B.V. | 82,046 | 3,194,000 | 0.28% | ||
| 27 | GEODE CAPITAL MANAGEMENT, LLC | 78,777 | 3,066,000 | 0.27% | ||
| 28 | HIGHBRIDGE CAPITAL MANAGEMENT LLC | 73,800 | 2,874,000 | 0.25% | Put | |
| 29 | Apex Capital Management | 73,731 | 2,870,000 | 0.25% | ||
| 30 | TIAA CREF INVESTMENT MANAGEMENT LLC | 67,163 | 2,615,000 | 0.23% | ||
| 31 | ALLIANCEBERNSTEIN L.P. | 53,580 | 2,086,000 | 0.18% | ||
| 32 | Cheyne Capital Management (UK) LLP | 50,044 | 1,949,000 | 0.17% | ||
| 33 | TCW GROUP INC | 47,110 | 1,834,000 | 0.16% | ||
| 34 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,800 | 1,822,000 | 0.16% | Put | |
| 35 | Informed Momentum Co LLC | 38,990 | 1,518,000 | 0.13% | ||
| 36 | BlackRock Investment Management, LLC | 37,973 | 1,478,000 | 0.13% | ||
| 37 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 37,100 | 1,444,000 | 0.13% | Call | |
| 38 | BAKER BROS. ADVISORS LP | 36,776 | 1,432,000 | 0.13% | ||
| 39 | Opaleye Management Inc. | 35,000 | 1,362,550 | 0.12% | ||
| 40 | REGENTS OF THE UNIVERSITY OF CALIFORNIA | 32,220 | 1,254,000 | 0.11% | ||
| 41 | WILLIAM HARRIS INVESTORS INC | 32,094 | 1,249,000 | 0.11% | ||
| 42 | SMITH ASSET MANAGEMENT GROUP LP | 31,510 | 1,227,000 | 0.11% | ||
| 43 | AMERIPRISE FINANCIAL INC | 31,025 | 1,208,000 | 0.11% | ||
| 44 | DEUTSCHE BANK AG\ | 29,657 | 1,154,000 | 0.10% | ||
| 45 | CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 29,614 | 1,153,000 | 0.10% | ||
| 46 | Cupps Capital Management, LLC | 27,655 | 1,076,000 | 0.09% | ||
| 47 | WELLS FARGO & COMPANY/MN | 26,315 | 1,024,000 | 0.09% | ||
| 48 | ROYAL BANK OF CANADA | 25,687 | 1,000,000 | 0.09% | ||
| 49 | CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 25,645 | 998,000 | 0.09% | ||
| 50 | RUSSELL FRANK CO/ | 25,429 | 990,000 | 0.09% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
