| # | % | |||||
|---|---|---|---|---|---|---|
| 1 | FMR LLC | 3,805,905 | 175,566,000 | 10.48% | ||
| 2 | Novo Holdings A/S | 3,610,487 | 166,552,000 | 9.95% | ||
| 3 | JHL Capital Group LLC | 3,000,000 | 138,390,000 | 8.26% | ||
| 4 | VANGUARD GROUP INC | 2,356,331 | 108,698,000 | 6.49% | ||
| 5 | PRICE T ROWE ASSOCIATES INC /MD/ | 2,055,762 | 94,832,000 | 5.66% | ||
| 6 | BlackRock Fund Advisors | 1,257,142 | 57,992,000 | 3.46% | ||
| 7 | ORBIMED ADVISORS LLC | 1,166,200 | 53,797,000 | 3.21% | ||
| 8 | STATE STREET CORP | 1,134,521 | 52,335,000 | 3.13% | ||
| 9 | THREE BAYS CAPITAL LP | 846,007 | 39,026,000 | 2.33% | ||
| 10 | FRANKLIN RESOURCES INC | 805,586 | 37,162,000 | 2.22% | ||
| 11 | Point72 Asset Management, L.P. | 786,300 | 36,272,000 | 2.17% | ||
| 12 | GOLDMAN SACHS GROUP INC | 742,825 | 34,267,000 | 2.05% | ||
| 13 | BlackRock Institutional Trust Company, N.A. | 740,186 | 34,145,000 | 2.04% | ||
| 14 | Fiera Capital Corp | 727,890 | 33,577,000 | 2.01% | ||
| 15 | EAGLE ASSET MANAGEMENT INC | 526,728 | 24,297,000 | 1.45% | ||
| 16 | Redmile Group, LLC | 505,154 | 23,303,000 | 1.39% | ||
| 17 | JANUS HENDERSON INVESTORS US LLC | 498,681 | 23,004,000 | 1.37% | ||
| 18 | Broadfin Capital, LLC | 410,000 | 18,913,000 | 1.13% | ||
| 19 | SECTORAL ASSET MANAGEMENT INC | 389,363 | 17,961,000 | 1.07% | ||
| 20 | MORGAN STANLEY | 381,239 | 17,586,000 | 1.05% | ||
| 21 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 365,200 | 16,847,000 | 1.01% | Put | |
| 22 | MILLENNIUM MANAGEMENT LLC | 364,953 | 16,835,000 | 1.01% | ||
| 23 | WELLS FARGO & COMPANY/MN | 339,390 | 15,655,000 | 0.93% | ||
| 24 | NORTHERN TRUST CORP | 338,776 | 15,628,000 | 0.93% | ||
| 25 | Allianz Asset Management GmbH | 261,434 | 13,934,000 | 0.83% | ||
| 26 | Senator Investment Group LP | 300,000 | 13,839,000 | 0.83% | ||
| 27 | EMERALD ACQUISITION LTD. | 299,751 | 13,828,000 | 0.83% | ||
| 28 | WELLINGTON MANAGEMENT GROUP LLP | 295,585 | 13,635,000 | 0.81% | ||
| 29 | SUFFOLK CAPITAL MANAGEMENT LLC | 252,355 | 11,641,000 | 0.70% | ||
| 30 | EverPoint Asset Management, LLC | 250,000 | 11,533,000 | 0.69% | Put | |
| 31 | PICTET ASSET MANAGEMENT LTD | 245,798 | 11,339,000 | 0.68% | ||
| 32 | NORGES BANK | 239,782 | 10,565,000 | 0.63% | ||
| 33 | GEODE CAPITAL MANAGEMENT, LLC | 224,281 | 10,346,000 | 0.62% | ||
| 34 | BANK OF AMERICA CORP /DE/ | 216,786 | 10,000,000 | 0.60% | ||
| 35 | Ghost Tree Capital, LLC | 200,000 | 9,226,000 | 0.55% | Call | |
| 36 | CLOUGH CAPITAL PARTNERS L P | 192,500 | 8,880,000 | 0.53% | ||
| 37 | EATON VANCE MANAGEMENT | 177,773 | 8,201,000 | 0.49% | ||
| 38 | SUSQUEHANNA INTERNATIONAL GROUP, LLP | 171,800 | 7,925,000 | 0.47% | Call | |
| 39 | Bank of New York Mellon Corp | 165,038 | 7,613,000 | 0.45% | ||
| 40 | AXA S.A. | 164,637 | 7,595,000 | 0.45% | ||
| 41 | Rock Springs Capital Management LP | 148,000 | 6,827,000 | 0.41% | ||
| 42 | VOYA INVESTMENT MANAGEMENT LLC | 142,268 | 6,563,000 | 0.39% | ||
| 43 | Cannell & Co. | 140,775 | 6,494,000 | 0.39% | ||
| 44 | TIAA CREF INVESTMENT MANAGEMENT LLC | 139,404 | 6,431,000 | 0.38% | ||
| 45 | BARCLAYS PLC | 122,100 | 5,632,000 | 0.34% | Call | |
| 46 | Invesco Ltd. | 118,638 | 5,472,000 | 0.33% | ||
| 47 | BlackRock Investment Management, LLC | 114,778 | 5,295,000 | 0.32% | ||
| 48 | HIGHLAND CAPITAL MANAGEMENT LP | 113,000 | 5,212,000 | 0.31% | ||
| 49 | DEUTSCHE BANK AG\ | 111,902 | 5,160,000 | 0.31% | ||
| 50 | OppenheimerFunds, Inc. | 110,230 | 5,085,000 | 0.30% |
From 2023-01-03 onward, the SEC requires values to be reported in nearest dollars. Earlier filings reported values in thousands; therefore, positions shown as $0 in older filings may represent actual values between $0–$999.
